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Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz, Jennifer A. Doudna
doi: https://doi.org/10.1101/160036
Janice S. Chen
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
Yavuz S. Dagdas
2Biophysics Graduate Group, University of California, Berkeley, California 94720, USA
Benjamin P. Kleinstiver
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
4Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Moira M. Welch
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Lucas B. Harrington
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
Samuel H. Sternberg
5Department of Chemistry, University of California, Berkeley, California 94720, USA
J. Keith Joung
3Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
4Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Ahmet Yildiz
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
6Department of Physics, University of California, Berkeley, California 94720, USA
Jennifer A. Doudna
1Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA
5Department of Chemistry, University of California, Berkeley, California 94720, USA
7Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
8Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA

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Posted August 12, 2017.
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy
Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz, Jennifer A. Doudna
bioRxiv 160036; doi: https://doi.org/10.1101/160036
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