New Results
Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments
View ORCID ProfileChristina K. Yung, Brian D. O’Connor, Sergei Yakneen, Junjun Zhang, Kyle Ellrott, Kortine Kleinheinz, Naoki Miyoshi, Keiran M. Raine, Romina Royo, Gordon B. Saksena, Matthias Schlesner, Solomon I. Shorser, Miguel Vazquez, Joachim Weischenfeldt, Denis Yuen, Adam P. Butler, Brandi N. Davis-Dusenbery, Roland Eils, Vincent Ferretti, Robert L. Grossman, Olivier Harismendy, Youngwook Kim, Hidewaki Nakagawa, Steven J. Newhouse, David Torrents, Lincoln D. Stein, on behalf of the PCAWG Technical Working Group, Javier Bartolomé Rodriguez, Keith A. Boroevich, Rich Boyce, Angela N. Brooks, Alex Buchanan, Ivo Buchhalter, Niall J. Byrne, Andy Cafferkey, Peter J. Campbell, Zhaohong Chen, Sunghoon Cho, Wan Choi, Peter Clapham, Francisco M. De La Vega, Jonas Demeulemeester, Michelle T. Dow, Lewis J. Dursi, Juergen Eils, Claudiu Farcas, Francesco Favero, Nodirjon Fayzullaev, Paul Flicek, Nuno A. Fonseca, Josep L.l. Gelpi, Gad Getz, Bob Gibson, Michael C. Heinold, Julian M. Hess, Oliver Hofmann, Jongwhi H. Hong, Thomas J. Hudson, Daniel Huebschmann, Barbara Hutter, Carolyn M. Hutter, Seiya Imoto, Sinisa Ivkovic, Seung-Hyup Jeon, Wei Jiao, Jongsun Jung, Rolf Kabbe, Andre Kahles, Jules Kerssemakers, Hyunghwan Kim, Hyung-Lae Kim, Jihoon Kim, Jan O. Korbel, Michael Koscher, Antonios Koures, Milena Kovacevic, Chris Lawerenz, Ignaty Leshchiner, Dimitri G. Livitz, George L. Mihaiescu, Sanja Mijalkovic, Ana Mijalkovic Lazic, Satoru Miyano, Hardeep K. Nahal, Mia Nastic, Jonathan Nicholson, David Ocana, Kazuhiro Ohi, Lucila Ohno-Machado, Larsson Omberg, B.F. Francis Ouellette, Nagarajan Paramasivam, Marc D. Perry, Todd D. Pihl, Manuel Prinz, Montserrat Puiggròs, Petar Radovic, Esther Rheinbay, Mara W. Rosenberg, Charles Short, Heidi J. Sofia, Jonathan Spring, Adam J. Struck, Grace Tiao, Nebojsa Tijanic, Peter Van Loo, David Vicente, Jeremiah A. Wala, Zhining Wang, Johannes Werner, Ashley Williams, Youngchoon Woo, Adam J. Wright, Qian Xiang, the PCAWG Network
doi: https://doi.org/10.1101/161638
Christina K. Yung
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Brian D. O’Connor
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.UC Santa Cruz Genomics Institute, University of California Santa Cruz, Santa Cruz, California, 95065, USA.
Sergei Yakneen
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Baden-Württemberg, 69120, Germany.
Junjun Zhang
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Kyle Ellrott
Department of Computational Biology, Oregon Health and Science University, Portland, Oregon, 97239, USA.
Kortine Kleinheinz
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Department for Bioinformatics and Functional Genomics, Institutefor Pharmacy and Molecular Biotechnology and BioQuant, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Naoki Miyoshi
Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo,108-8639, Japan.
Keiran M. Raine
Cancer Ageing and Somatic Mutation Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA,United Kingdom.
Romina Royo
Department of Life Sciences, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.
Gordon B. Saksena
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.
Matthias Schlesner
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Solomon I. Shorser
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Miguel Vazquez
Structural Computational Biology Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Madrid, 28029, Spain.
Joachim Weischenfeldt
Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Baden-Württemberg, 69120, Germany.BRIC/Finsen Laboratory, Rigshospitalet, Copenhagen, 2200, Denmark.
Denis Yuen
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Adam P. Butler
Cancer Ageing and Somatic Mutation Programme, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA,United Kingdom.
Brandi N. Davis-Dusenbery
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Roland Eils
Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Department for Bioinformatics and Functional Genomics, Institutefor Pharmacy and Molecular Biotechnology and BioQuant, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Vincent Ferretti
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Robert L. Grossman
Center for Data Intensive Science, University of Chicago, Chicago, Illinois,60637, USA.
Olivier Harismendy
Department of Medicine, University of California San Diego, San Diego, California, 92093, USA.Moores Cancer Center, Department of Medicine, Division of Biomedical Informatics, University of California San Diego, San Diego, California, 92093, USA.
Youngwook Kim
Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, School of Medicine, Seoul, 135-710, South Korea.
Hidewaki Nakagawa
Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, 108-8639, Japan.
Steven J. Newhouse
Technical Services Cluster, European Molecular Biology Laboratory, European Bioinforamtics Institute, Hinxton, Cambridge, CB10 1SD,United Kingdom.
David Torrents
Department of Life Sciences, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalunya, 8010, Spain.
Lincoln D. Stein
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
Javier Bartolomé Rodriguez
Department of Operations, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.
Keith A. Boroevich
Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, 230-0045, Japan.
Rich Boyce
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Angela N. Brooks
Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, 95065, USA.
Alex Buchanan
Department of Computational Biology, Oregon Health and Science University, Portland, Oregon,97239, USA.
Ivo Buchhalter
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology and BioQuant, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Niall J. Byrne
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Andy Cafferkey
Technical Services Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Peter J. Campbell
Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom.
Zhaohong Chen
Department of Medicine, University of California San Diego, San Diego, California, 92093, USA.
Sunghoon Cho
PDXen Biosystems Inc., Seoul, 4900, South Korea.
Wan Choi
Electronics and Telecommunications Research Institute, Daejon, 34129, South Korea.
Peter Clapham
Informatics Support Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom.
Francisco M. De La Vega
Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, California, 94305, USA.Annai Systems, Inc., Carlsbad, California, 92011, USA.
Jonas Demeulemeester
The Francis Crick Institute, London, NW1 1AT, United Kingdom.Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium.
Michelle T. Dow
Biomedical Informatics, University of California San Diego, San Diego, California, 92093, USA.
Lewis J. Dursi
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.The Centre for Computational Medicine, The Hospital for Sick Children, Toronto, Ontario, M5G 0A4, Canada.
Juergen Eils
Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Claudiu Farcas
Health System Department of Biomedical Informatics, University of California San Diego, La Jolla, California, 92093, USA.
Francesco Favero
BRIC/Finsen Laboratory, Rigshospitalet, Copenhagen, 2200, Denmark.
Nodirjon Fayzullaev
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Paul Flicek
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Nuno A. Fonseca
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Josep L.l. Gelpi
Department of Life 528 Sciences, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.Department of Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Catalunya, 8028, Spain.
Gad Getz
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
Bob Gibson
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Michael C. Heinold
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology and BioQuant, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Julian M. Hess
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.
Oliver Hofmann
Center for Cancer Research, University of Melbourne, Melbourne, VIC 3001, Australia.
Jongwhi H. Hong
Genome Data Integration Center, Syntekabio Inc., Daejon, 34025, South Korea.
Thomas J. Hudson
Genomics Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 534 0A3, Canada.Oncology Discovery and Early Development, AbbVie, Redwood City, California, 94063, USA.
Daniel Huebschmann
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology and BioQuant, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Barbara Hutter
Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 536 69120, Germany.Division of Applied Bioinformatics, National Center for Tumor Diseases, Heidelberg, Baden-Württemberg, 69120, Germany.
Carolyn M. Hutter
Division of Genomic Medicine, National Human Genome Research Institute Bethesda, Maryland, 20852, USA.
Seiya Imoto
Health Intelligence Center, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Sinisa Ivkovic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Seung-Hyup Jeon
Electronics and Telecommunications Research Institute, Daejon, 34129, South Korea.
Wei Jiao
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Jongsun Jung
Genome Data Integration Center, Syntekabio Inc., Daejon, 34025, South Korea.
Rolf Kabbe
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Andre Kahles
Department of Computer Science, ETH Zurich, Zurich, Zurich, 8092, Switzerland.Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA.
Jules Kerssemakers
German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Hyunghwan Kim
Electronics and Telecommunications Research Institute, Daejon, 34129, South Korea.
Hyung-Lae Kim
Department of Biochemistry, Ewha Womans University, Seoul, O7985, South Korea.PGM21, Seoul, O7985, South Korea.
Jihoon Kim
Department of Medicine, University of California San Diego, San Diego, California, 92093, USA.
Jan O. Korbel
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Baden-Württemberg, 69120, Germany.
Michael Koscher
German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Antonios Koures
Department of Medicine, University of California San Diego, San Diego, California, 92093, USA.
Milena Kovacevic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Chris Lawerenz
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Ignaty Leshchiner
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.
Dimitri G. Livitz
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.
George L. Mihaiescu
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Sanja Mijalkovic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Ana Mijalkovic Lazic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Satoru Miyano
Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Hardeep K. Nahal
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Mia Nastic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Jonathan Nicholson
Informatics Support Group, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom.
David Ocana
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Kazuhiro Ohi
Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, 108-8639, Japan.
Lucila Ohno-Machado
Health System Department of Biomedical Informatics, University of California San Diego, La Jolla, California, 92093, USA.
Larsson Omberg
Systems Biology, Sage Bionetworks, Seattle, Washington, 98112, USA.
B.F. Francis Ouellette
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada.
Nagarajan Paramasivam
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Baden-Württemberg, 69120, Germany.
Marc D. Perry
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Todd D. Pihl
CSRA Incorporated, Fairfax, Virginia, 22042, USA.
Manuel Prinz
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Montserrat Puiggròs
Department of Life 528 Sciences, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.
Petar Radovic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Esther Rheinbay
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
Mara W. Rosenberg
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA.
Charles Short
European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, CB10 1SD, United Kingdom.
Heidi J. Sofia
National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, 20892-551 9305, USA.
Jonathan Spring
Center for Data Intensive Science, University of Chicago, Chicago, Illinois, 60637, USA.
Adam J. Struck
Department of Computational Biology, Oregon Health and Science University, Portland, Oregon,97239, USA.
Grace Tiao
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.
Nebojsa Tijanic
Seven Bridges, Cambridge, Massachusetts, 02142, USA.
Peter Van Loo
The Francis Crick Institute, London, NW1 1AT, United Kingdom.Department of Human Genetics, University of Leuven, B-3000 Leuven, Belgium.
David Vicente
Department of Operations, Barcelona Supercomputing Center, Barcelona, Catalunya, 8034, Spain.
Jeremiah A. Wala
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, 02142, USA.Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA.
Zhining Wang
TCGA 553 Program Office, National Cancer Institute, Bethesda, Maryland, 20892, USA.
Johannes Werner
Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Baden-Württemberg, 69120, Germany.
Ashley Williams
Department of Medicine, University of California San Diego, San Diego, California, 92093, USA.
Youngchoon Woo
Electronics and Telecommunications Research Institute, Daejon, 34129, South Korea.
Adam J. Wright
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Qian Xiang
Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Ontario, M5G 0A3, Canada.
Abstract
The International Cancer Genome Consortium (ICGC)’s Pan-Cancer Analysis of Whole Genomes (PCAWG) project aimed to categorize somatic and germline variations in both coding and non-coding regions in over 2,800 cancer patients. To provide this dataset to the research working groups for downstream analysis, the PCAWG Technical Working Group marshalled ~800TB of sequencing data from distributed geographical locations; developed portable software for uniform alignment, variant calling, artifact filtering and variant merging; performed the analysis in a geographically and technologically disparate collection of compute environments; and disseminated high-quality validated consensus variants to the working groups. The PCAWG dataset has been mirrored to multiple repositories and can be located using the ICGC Data Portal. The PCAWG workflows are also available as Docker images through Dockstore enabling researchers to replicate our analysis on their own data.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted July 10, 2017.
Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments
Christina K. Yung, Brian D. O’Connor, Sergei Yakneen, Junjun Zhang, Kyle Ellrott, Kortine Kleinheinz, Naoki Miyoshi, Keiran M. Raine, Romina Royo, Gordon B. Saksena, Matthias Schlesner, Solomon I. Shorser, Miguel Vazquez, Joachim Weischenfeldt, Denis Yuen, Adam P. Butler, Brandi N. Davis-Dusenbery, Roland Eils, Vincent Ferretti, Robert L. Grossman, Olivier Harismendy, Youngwook Kim, Hidewaki Nakagawa, Steven J. Newhouse, David Torrents, Lincoln D. Stein, on behalf of the PCAWG Technical Working Group, Javier Bartolomé Rodriguez, Keith A. Boroevich, Rich Boyce, Angela N. Brooks, Alex Buchanan, Ivo Buchhalter, Niall J. Byrne, Andy Cafferkey, Peter J. Campbell, Zhaohong Chen, Sunghoon Cho, Wan Choi, Peter Clapham, Francisco M. De La Vega, Jonas Demeulemeester, Michelle T. Dow, Lewis J. Dursi, Juergen Eils, Claudiu Farcas, Francesco Favero, Nodirjon Fayzullaev, Paul Flicek, Nuno A. Fonseca, Josep L.l. Gelpi, Gad Getz, Bob Gibson, Michael C. Heinold, Julian M. Hess, Oliver Hofmann, Jongwhi H. Hong, Thomas J. Hudson, Daniel Huebschmann, Barbara Hutter, Carolyn M. Hutter, Seiya Imoto, Sinisa Ivkovic, Seung-Hyup Jeon, Wei Jiao, Jongsun Jung, Rolf Kabbe, Andre Kahles, Jules Kerssemakers, Hyunghwan Kim, Hyung-Lae Kim, Jihoon Kim, Jan O. Korbel, Michael Koscher, Antonios Koures, Milena Kovacevic, Chris Lawerenz, Ignaty Leshchiner, Dimitri G. Livitz, George L. Mihaiescu, Sanja Mijalkovic, Ana Mijalkovic Lazic, Satoru Miyano, Hardeep K. Nahal, Mia Nastic, Jonathan Nicholson, David Ocana, Kazuhiro Ohi, Lucila Ohno-Machado, Larsson Omberg, B.F. Francis Ouellette, Nagarajan Paramasivam, Marc D. Perry, Todd D. Pihl, Manuel Prinz, Montserrat Puiggròs, Petar Radovic, Esther Rheinbay, Mara W. Rosenberg, Charles Short, Heidi J. Sofia, Jonathan Spring, Adam J. Struck, Grace Tiao, Nebojsa Tijanic, Peter Van Loo, David Vicente, Jeremiah A. Wala, Zhining Wang, Johannes Werner, Ashley Williams, Youngchoon Woo, Adam J. Wright, Qian Xiang, the PCAWG Network
bioRxiv 161638; doi: https://doi.org/10.1101/161638
Large-Scale Uniform Analysis of Cancer Whole Genomes in Multiple Computing Environments
Christina K. Yung, Brian D. O’Connor, Sergei Yakneen, Junjun Zhang, Kyle Ellrott, Kortine Kleinheinz, Naoki Miyoshi, Keiran M. Raine, Romina Royo, Gordon B. Saksena, Matthias Schlesner, Solomon I. Shorser, Miguel Vazquez, Joachim Weischenfeldt, Denis Yuen, Adam P. Butler, Brandi N. Davis-Dusenbery, Roland Eils, Vincent Ferretti, Robert L. Grossman, Olivier Harismendy, Youngwook Kim, Hidewaki Nakagawa, Steven J. Newhouse, David Torrents, Lincoln D. Stein, on behalf of the PCAWG Technical Working Group, Javier Bartolomé Rodriguez, Keith A. Boroevich, Rich Boyce, Angela N. Brooks, Alex Buchanan, Ivo Buchhalter, Niall J. Byrne, Andy Cafferkey, Peter J. Campbell, Zhaohong Chen, Sunghoon Cho, Wan Choi, Peter Clapham, Francisco M. De La Vega, Jonas Demeulemeester, Michelle T. Dow, Lewis J. Dursi, Juergen Eils, Claudiu Farcas, Francesco Favero, Nodirjon Fayzullaev, Paul Flicek, Nuno A. Fonseca, Josep L.l. Gelpi, Gad Getz, Bob Gibson, Michael C. Heinold, Julian M. Hess, Oliver Hofmann, Jongwhi H. Hong, Thomas J. Hudson, Daniel Huebschmann, Barbara Hutter, Carolyn M. Hutter, Seiya Imoto, Sinisa Ivkovic, Seung-Hyup Jeon, Wei Jiao, Jongsun Jung, Rolf Kabbe, Andre Kahles, Jules Kerssemakers, Hyunghwan Kim, Hyung-Lae Kim, Jihoon Kim, Jan O. Korbel, Michael Koscher, Antonios Koures, Milena Kovacevic, Chris Lawerenz, Ignaty Leshchiner, Dimitri G. Livitz, George L. Mihaiescu, Sanja Mijalkovic, Ana Mijalkovic Lazic, Satoru Miyano, Hardeep K. Nahal, Mia Nastic, Jonathan Nicholson, David Ocana, Kazuhiro Ohi, Lucila Ohno-Machado, Larsson Omberg, B.F. Francis Ouellette, Nagarajan Paramasivam, Marc D. Perry, Todd D. Pihl, Manuel Prinz, Montserrat Puiggròs, Petar Radovic, Esther Rheinbay, Mara W. Rosenberg, Charles Short, Heidi J. Sofia, Jonathan Spring, Adam J. Struck, Grace Tiao, Nebojsa Tijanic, Peter Van Loo, David Vicente, Jeremiah A. Wala, Zhining Wang, Johannes Werner, Ashley Williams, Youngchoon Woo, Adam J. Wright, Qian Xiang, the PCAWG Network
bioRxiv 161638; doi: https://doi.org/10.1101/161638
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