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Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

View ORCID ProfileSelen Atasoy, Leor Roseman, Mendel Kaelen, Morten L. Kringelbach, Gustavo Deco, Robin Carhart-Harris
doi: https://doi.org/10.1101/163667
Selen Atasoy
1 Center of Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain
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Leor Roseman
2 Division of Brain Sciences, Imperial College London
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Mendel Kaelen
2 Division of Brain Sciences, Imperial College London
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Morten L. Kringelbach
3 Department of Psychiatry, University of Oxford
4 Center for Music in the Brain, Aarhus University, Denmark
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Gustavo Deco
1 Center of Brain and Cognition, Universitat Pompeu Fabra, Barcelona, Spain
5 ICREA, Instituci Catalana de Recerca i Estudis Avancats (ICREA), Spain
6 Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
7 School of Psychological Sciences, Monash University, Melbourne, Australia
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Robin Carhart-Harris
2 Division of Brain Sciences, Imperial College London
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Abstract

Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used ‘connectome-harmonic decomposition’, a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

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Posted July 27, 2017.
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Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
Selen Atasoy, Leor Roseman, Mendel Kaelen, Morten L. Kringelbach, Gustavo Deco, Robin Carhart-Harris
bioRxiv 163667; doi: https://doi.org/10.1101/163667
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Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD
Selen Atasoy, Leor Roseman, Mendel Kaelen, Morten L. Kringelbach, Gustavo Deco, Robin Carhart-Harris
bioRxiv 163667; doi: https://doi.org/10.1101/163667

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