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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, View ORCID ProfileRoch-Philippe Charles
doi: https://doi.org/10.1101/164533
Matthias A. Roelli
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Dorothée Ruffieux-Daidié
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Amandine Stooss
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Oussama ElMokh
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Wayne A. Phillips
3Cancer Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia
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Matthias S. Dettmer
2Institut für Pathologie, Universität Bern, Bern, Switzerland
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Roch-Philippe Charles
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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  • ORCID record for Roch-Philippe Charles
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Article Information

doi 
https://doi.org/10.1101/164533
History 
  • July 18, 2017.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Matthias A. Roelli1,
  2. Dorothée Ruffieux-Daidié1,
  3. Amandine Stooss1,
  4. Oussama ElMokh1,
  5. Wayne A. Phillips3,
  6. Matthias S. Dettmer2 and
  7. Roch-Philippe Charles1
  1. 1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
  2. 2Institut für Pathologie, Universität Bern, Bern, Switzerland
  3. 3Cancer Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia
  1. Corresponding author: Roch-Philippe Charles, Institute für Biochemie und Molekular Medizin, Universität Bern, Bühlstrasse28, CH-3012 Bern, Switzerland.Phone: +41 31 631 4344 Email:roch-philippe.charles{at}ibmm.unibe.ch
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Posted July 18, 2017.
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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors
Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, Roch-Philippe Charles
bioRxiv 164533; doi: https://doi.org/10.1101/164533
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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors
Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, Roch-Philippe Charles
bioRxiv 164533; doi: https://doi.org/10.1101/164533

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