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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, View ORCID ProfileRoch-Philippe Charles
doi: https://doi.org/10.1101/164533
Matthias A. Roelli
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Dorothée Ruffieux-Daidié
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Amandine Stooss
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Oussama ElMokh
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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Wayne A. Phillips
3Cancer Biology Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia
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Matthias S. Dettmer
2Institut für Pathologie, Universität Bern, Bern, Switzerland
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Roch-Philippe Charles
1Institut für Biochemie und Molekulare Medizin, Universität Bern, Bern, Switzerland
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  • ORCID record for Roch-Philippe Charles
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Posted July 18, 2017.
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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors
Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, Roch-Philippe Charles
bioRxiv 164533; doi: https://doi.org/10.1101/164533
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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors
Matthias A. Roelli, Dorothée Ruffieux-Daidié, Amandine Stooss, Oussama ElMokh, Wayne A. Phillips, Matthias S. Dettmer, Roch-Philippe Charles
bioRxiv 164533; doi: https://doi.org/10.1101/164533

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