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Convergent evolution as an indicator for selection during acute HIV-1 infection

Frederic Bertels, Karin J. Metzner, Roland Regoes
doi: https://doi.org/10.1101/168260
Frederic Bertels
1Department for Environmental Systems Sciences, ETH Zurich, Zurich, Switzerland
2Max Planck Institute for Evolutionary Biology, Department for Microbial Population Biology, Plön, Germany
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Karin J. Metzner
3Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
4Insitute of Medical Virology, University of Zurich, Zurich, Switzerland
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Roland Regoes
1Department for Environmental Systems Sciences, ETH Zurich, Zurich, Switzerland
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Abstract

Convergent evolution describes the process of different populations acquiring similar phenotypes or genotypes. Complex organisms with large genomes only rarely and only under very strong selection converge to the same genotype. In contrast, independent virus populations with very small genomes often acquire identical mutations. Here we test the hypothesis of whether convergence in early HIV-1 infection is common enough to serve as an indicator for selection. To this end, we measure the number of convergent mutations in a well-studied dataset of full-length HIV-1 env genes sampled from HIV-1 infected individuals during early infection. We compare this data to a neutral model and find an excess of convergent mutations. Convergent mutations are not evenly distributed across the env gene, but more likely to occur in gp41, which suggests that convergent mutations provide a selective advantage and hence are positively selected. In contrast, mutations that are only found in an HIV-1 population of a single individual are significantly affected by purifying selection. Our analysis suggests that comparisons between convergent and private mutations with neutral models allow us to identify positive and negative selection in small viral genomes. Our results also show that selection significantly shapes HIV-1 populations even before the onset of the adaptive immune system.

Footnotes

  • Cite as: Bertels F, Metzner KJ, Regoes RR. Convergent evolution as an indicator for selection during acute HIV-1 infection. bioRxiv 168260, ver. 4 peer-reviewed and recommended by PCI Evolutionary Biology (2018). DOI: 10.1101/168260

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted November 20, 2018.
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Convergent evolution as an indicator for selection during acute HIV-1 infection
Frederic Bertels, Karin J. Metzner, Roland Regoes
bioRxiv 168260; doi: https://doi.org/10.1101/168260
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Convergent evolution as an indicator for selection during acute HIV-1 infection
Frederic Bertels, Karin J. Metzner, Roland Regoes
bioRxiv 168260; doi: https://doi.org/10.1101/168260

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