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Acute stress induces long-lasting alterations in the dopaminergic system of female mice

Romy Wichmann, Caitlin M. Vander Weele, Ariella S. Yosafat, Evelien H.S. Schut, Jeroen P. H. Verharen, Suganya Sridharma, Cody A. Siciliano, Ehsan M. Izadmehr, Kathryn M. Farris, Craig P. Wildes, Eyal Y. Kimchi, View ORCID ProfileKay M. Tye
doi: https://doi.org/10.1101/168492
Romy Wichmann
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Caitlin M. Vander Weele
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Ariella S. Yosafat
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Evelien H.S. Schut
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
2Department of Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
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Jeroen P. H. Verharen
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
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Suganya Sridharma
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Cody A. Siciliano
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Ehsan M. Izadmehr
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Kathryn M. Farris
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Craig P. Wildes
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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Eyal Y. Kimchi
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
4Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
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Kay M. Tye
1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
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  • ORCID record for Kay M. Tye
  • For correspondence: kaytye@mit.edu
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Abstract

Stress is a risk factor for many neuropsychiatric disorders, and the mesolimbic dopamine (DA) pathway is a crucial node of vulnerability. Despite the high prevalence of stress-related neuropsychiatric disorders in women, preclinical knowledge on the impact of stress on neural circuitry has predominantly been acquired in males. Here, we examine how a non-social stressor impacts the effect of DA neurotransmission on social and reward-related behaviors in female mice. Acute stress exposure attenuated the anti-social effects of photoinhibiting ventral tegmental area (VTA) DA neurons and transformed photoactivation of these cells into an anti-social signal. Fast-scan cyclic voltammetry (FSCV) revealed an enhancement in optogenetically-induced DA release after stress. 60 days after stress, mice showed distinct patterns of intra-cranial self-stimulation of VTA DA neurons. Our results reveal the impact stress exerts on females and show that neural and behavioral changes induced by acute stress exposure are still present months later.

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Posted July 27, 2017.
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Acute stress induces long-lasting alterations in the dopaminergic system of female mice
Romy Wichmann, Caitlin M. Vander Weele, Ariella S. Yosafat, Evelien H.S. Schut, Jeroen P. H. Verharen, Suganya Sridharma, Cody A. Siciliano, Ehsan M. Izadmehr, Kathryn M. Farris, Craig P. Wildes, Eyal Y. Kimchi, Kay M. Tye
bioRxiv 168492; doi: https://doi.org/10.1101/168492
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Acute stress induces long-lasting alterations in the dopaminergic system of female mice
Romy Wichmann, Caitlin M. Vander Weele, Ariella S. Yosafat, Evelien H.S. Schut, Jeroen P. H. Verharen, Suganya Sridharma, Cody A. Siciliano, Ehsan M. Izadmehr, Kathryn M. Farris, Craig P. Wildes, Eyal Y. Kimchi, Kay M. Tye
bioRxiv 168492; doi: https://doi.org/10.1101/168492

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