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A compartmentalized, self-extinguishing signaling network mediates crossover control in meiosis

Liangyu Zhang, Simone Köhler, Regina Rillo-Bohn, Abby F. Dernburg
doi: https://doi.org/10.1101/168948
Liangyu Zhang
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3220, USA
2Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
3Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
4California Institute for Quantitative Biosciences, Berkeley, CA 94720, USA
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Simone Köhler
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3220, USA
2Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
3Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
4California Institute for Quantitative Biosciences, Berkeley, CA 94720, USA
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Regina Rillo-Bohn
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3220, USA
2Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
3Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
4California Institute for Quantitative Biosciences, Berkeley, CA 94720, USA
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Abby F. Dernburg
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3220, USA
2Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
3Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
4California Institute for Quantitative Biosciences, Berkeley, CA 94720, USA
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  • For correspondence: afdernburg@berkeley.edu
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Abstract

Meiotic recombination between homologous chromosomes is tightly regulated to ensure proper chromosome segregation. Each chromosome pair typically undergoes at least one crossover event (crossover assurance) but these exchanges are also strictly limited in number and widely spaced along chromosomes (crossover interference). This has implied the existence of chromosome-wide signals that regulate crossovers, but their molecular basis remains mysterious. Here we characterize a family of four related RING finger proteins in C. elegans. These proteins are recruited to the synaptonemal complex between paired homologs, where they act as two heterodimeric complexes, likely as E3 ubiquitin ligases. Genetic and cytological analysis reveals that they act with additional components to create a self-extinguishing circuit that controls crossover designation and maturation. These proteins also act at the top of a hierarchical chromosome remodeling process that enables crossovers to direct stepwise segregation. Work in diverse phyla indicates that related mechanisms mediate crossover control across eukaryotes.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted July 26, 2017.
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A compartmentalized, self-extinguishing signaling network mediates crossover control in meiosis
Liangyu Zhang, Simone Köhler, Regina Rillo-Bohn, Abby F. Dernburg
bioRxiv 168948; doi: https://doi.org/10.1101/168948
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A compartmentalized, self-extinguishing signaling network mediates crossover control in meiosis
Liangyu Zhang, Simone Köhler, Regina Rillo-Bohn, Abby F. Dernburg
bioRxiv 168948; doi: https://doi.org/10.1101/168948

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