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Functional corticostriatal connection topographies predict goal directed behaviour in humans

View ORCID ProfileAndre F. Marquand, Koen V. Haak, Christian F. Beckmann
doi: https://doi.org/10.1101/169151
Andre F. Marquand
1Radboud University Medical Centre, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
2Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
3Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, De Crespigny Park, London SE5 8AF, United Kingdom
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  • For correspondence: a.f.marquand@donders.ru.nl
Koen V. Haak
1Radboud University Medical Centre, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
2Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
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Christian F. Beckmann
1Radboud University Medical Centre, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
2Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, 6525 EN, Nijmegen, the Netherlands.
4Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford OX3 9DU, United Kingdom
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Summary

Anatomical tracing studies in non-human primates have suggested that corticostriatal connectivity is topographically organized: nearby locations in striatum are connected with nearby locations in cortex. The topographic organization of corticostriatal connectivity is thought to underpin many goal-directed behaviours, but these topographies have not been completely characterised in humans and their relationship to uniquely human behaviours remains to be fully determined. Instead, the dominant approach employs parcellations that cannot model the continuous nature of the topography, nor accommodate overlapping cortical projections in the striatum. Here, we employ a different approach to studying human corticostriatal circuitry: we estimate smoothly-varying and spatially overlapping ‘connection topographies’ from resting state fMRI. These correspond exceptionally well with and extend the topographies predicted from primate tracing studies. We show that striatal topography is preserved in regions not previously known to have topographic connections with the striatum and that many goal-directed behaviours can be mapped precisely onto individual variations in the spatial layout of striatal connectivity.

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Posted July 27, 2017.
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Functional corticostriatal connection topographies predict goal directed behaviour in humans
Andre F. Marquand, Koen V. Haak, Christian F. Beckmann
bioRxiv 169151; doi: https://doi.org/10.1101/169151
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Functional corticostriatal connection topographies predict goal directed behaviour in humans
Andre F. Marquand, Koen V. Haak, Christian F. Beckmann
bioRxiv 169151; doi: https://doi.org/10.1101/169151

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