Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The ANTs Longitudinal Cortical Thickness Pipeline

View ORCID ProfileNicholas J. Tustison, Andrew J. Holbrook, View ORCID ProfileBrian B. Avants, Jared M. Roberts, Philip A. Cook, View ORCID ProfileZachariah M. Reagh, James R. Stone, Daniel L. Gillen, View ORCID ProfileMichael A. Yassa, for the Alzheimer’s Disease Neuroimaging Initiative
doi: https://doi.org/10.1101/170209
Nicholas J. Tustison
1Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA
2Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Nicholas J. Tustison
Andrew J. Holbrook
3Department of Statistics, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brian B. Avants
4Department of Radiology, University of Pennsylvania, Philadelphia, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Brian B. Avants
Jared M. Roberts
2Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip A. Cook
4Department of Radiology, University of Pennsylvania, Philadelphia, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zachariah M. Reagh
2Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Zachariah M. Reagh
James R. Stone
1Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel L. Gillen
3Department of Statistics, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael A. Yassa
2Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michael A. Yassa
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Longitudinal studies of development and disease in the human brain have motivated the acquisition of large neuroimaging data sets and the concomitant development of robust methodological and statistical tools for quantifying neurostructural changes. Longitudinal-specific strategies for acquisition and processing have potentially significant benefits including more consistent estimates of intra-subject measurements while retaining predictive power. In this work, we introduce the open-source Advanced Normalization Tools (ANTs) cortical thickness longitudinal processing pipeline and its application on the first phase of the Alzheimer’s Disease Neuroimaging Initiative (ADNI-1) comprising over 600 subjects with multiple time points from baseline to 36 months. We demonstrate in these data that the single-subject template construction and native subject-space processing advantageously localizes data transformations and mitigates interpolation artifacts which results in a simultaneous minimization of within-subject variability and maximization of between-subject variability immediately estimable from a longitudinal mixed-effects modeling strategy. It is further shown that optimizing these dual criteria leads to greater scientific interpretability in terms of tighter confidence intervals in calculated mean trends, smaller prediction intervals, and narrower confidence intervals for determining cross-sectional effects. These concepts are first illustrated and explored in the entorhinal cortex. This evaluation strategy is then extended to the entire cortex, as defined by the Desikan-Killiany-Tourville labeling protocol, where comparisons are made with the popular crosssectional and longitudinal FreeSurfer processing streams.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted July 30, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The ANTs Longitudinal Cortical Thickness Pipeline
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
The ANTs Longitudinal Cortical Thickness Pipeline
Nicholas J. Tustison, Andrew J. Holbrook, Brian B. Avants, Jared M. Roberts, Philip A. Cook, Zachariah M. Reagh, James R. Stone, Daniel L. Gillen, Michael A. Yassa, for the Alzheimer’s Disease Neuroimaging Initiative
bioRxiv 170209; doi: https://doi.org/10.1101/170209
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
The ANTs Longitudinal Cortical Thickness Pipeline
Nicholas J. Tustison, Andrew J. Holbrook, Brian B. Avants, Jared M. Roberts, Philip A. Cook, Zachariah M. Reagh, James R. Stone, Daniel L. Gillen, Michael A. Yassa, for the Alzheimer’s Disease Neuroimaging Initiative
bioRxiv 170209; doi: https://doi.org/10.1101/170209

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (2543)
  • Biochemistry (4994)
  • Bioengineering (3497)
  • Bioinformatics (15279)
  • Biophysics (6926)
  • Cancer Biology (5427)
  • Cell Biology (7770)
  • Clinical Trials (138)
  • Developmental Biology (4558)
  • Ecology (7180)
  • Epidemiology (2059)
  • Evolutionary Biology (10260)
  • Genetics (7532)
  • Genomics (9826)
  • Immunology (4899)
  • Microbiology (13304)
  • Molecular Biology (5165)
  • Neuroscience (29568)
  • Paleontology (203)
  • Pathology (842)
  • Pharmacology and Toxicology (1470)
  • Physiology (2153)
  • Plant Biology (4780)
  • Scientific Communication and Education (1015)
  • Synthetic Biology (1343)
  • Systems Biology (4022)
  • Zoology (771)