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Catecholamines, not acetylcholine, alter cortical and perceptual dynamics in line with increased excitation-inhibition ratio

View ORCID ProfileThomas Pfeffer, Arthur-Ervin Avramiea, Guido Nolte, Andreas K. Engel, Klaus Linkenkaer-Hansen, Tobias H. Donner
doi: https://doi.org/10.1101/170613
Thomas Pfeffer
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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  • ORCID record for Thomas Pfeffer
Arthur-Ervin Avramiea
2Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands
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Guido Nolte
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Andreas K. Engel
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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Klaus Linkenkaer-Hansen
2Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University Amsterdam, The Netherlands
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Tobias H. Donner
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
3Department of Psychology, University of Amsterdam, The Netherlands
4Amsterdam Brain and Cognition, University of Amsterdam, The Netherlands
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Abstract

The ratio between excitatory and inhibitory neurons (E/I ratio) is vital for cortical circuit dynamics, computation, and behavior. This ratio may be under the dynamic control of neuromodulatory systems, which are in turn implicated in several neuropsychiatric disorders. In particular, the catecholaminergic (dopaminergic and noradrenergic) and cholinergic systems have highly specific effects on excitatory and inhibitory cortical neurons, which might translate into changes in the local net E/I ratio. Here, we assessed and compared their net effects on net E/I ratio in human cortex, through an integrated application of computational modeling, placebo-controlled pharmacological intervention, magnetoencephalographic recordings of cortical activity dynamics, and perceptual psychophysics. We found that catecholamines, but not acetylcholine, altered both the temporal structure of intrinsic activity fluctuations in visual and parietal cortex, and the volatility of perceptual inference based on ambiguous visual input. Both effects indicate that catecholamines increase the net E/I ratio in visual and parietal cortex.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 04, 2017.
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Catecholamines, not acetylcholine, alter cortical and perceptual dynamics in line with increased excitation-inhibition ratio
Thomas Pfeffer, Arthur-Ervin Avramiea, Guido Nolte, Andreas K. Engel, Klaus Linkenkaer-Hansen, Tobias H. Donner
bioRxiv 170613; doi: https://doi.org/10.1101/170613
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Catecholamines, not acetylcholine, alter cortical and perceptual dynamics in line with increased excitation-inhibition ratio
Thomas Pfeffer, Arthur-Ervin Avramiea, Guido Nolte, Andreas K. Engel, Klaus Linkenkaer-Hansen, Tobias H. Donner
bioRxiv 170613; doi: https://doi.org/10.1101/170613

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