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Liver physiological T1rho dynamics associated with age and gender

Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony WL Kwok, Eric KW Liu, Weitian Chen
doi: https://doi.org/10.1101/172478
Yì Xiáng J Wáng
1Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR
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Min Deng
1Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR
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Jiang Lin
2Department of Radiology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
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Anthony WL Kwok
3Department of Orthopedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR
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Eric KW Liu
1Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR
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Weitian Chen
1Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR
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Abstract

Purpose Using a single breathhold black blood sequence, the current study aims to understand the physiological ranges of liver T1rho relaxation for women and men.

Materials and Methods This volunteer study was conducted with institutional ethics committee approval, and included 62 females (age mean: 38.9 years; range: 18-75 years) and 34 males (age mean: 44.7 years, range: 24-80 years). MRI was conducted with a 3.0 T scanner, with six spin-lock times of 0, 10, 20, 25, 35, 50msec and a single breathhold of 12 seconds. Six slices were acquired for each examination.

Results Female liver T1rho value ranged between 35.07 to 51.97ms, showed an age-dependent decrease with younger women had a higher measurement. Male Liver T1rho values ranged between 34.94 to 43.39 ms, and there was no evidential age-dependence. For females, there was a trend that liver T1rho value could be 4%-5% lower during menstrual phase than nonmenstrual phase. For both females and males, no evidential association was seen between body mass index and liver T1rho.

Conclusion Liver T1rho physiological value for males have relatively narrow distribution, while physiological value for females have wider distribution, and decreases with age.

Key points 1. Liver T1rho shows an age-dependency in women, with young women showing higher measurement. This age-dependency of liver T1rho measurement is not evidential in men. Post-menopausal women have similar liver T1rho value as men.

2. Women at menstrual phase may have slight lower liver T1rho measurement.

3. No association was noted between body mass index and liver T1rho

4. When blood signal suppression sequence is used, in a population of 62 healthy women and 34 healthy men, the highest measured liver T1rho was 52 msec for young women, 44.7 msec for post-menopausal women, and 43.4 msec for men.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted August 04, 2017.
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Liver physiological T1rho dynamics associated with age and gender
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony WL Kwok, Eric KW Liu, Weitian Chen
bioRxiv 172478; doi: https://doi.org/10.1101/172478
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Liver physiological T1rho dynamics associated with age and gender
Yì Xiáng J Wáng, Min Deng, Jiang Lin, Anthony WL Kwok, Eric KW Liu, Weitian Chen
bioRxiv 172478; doi: https://doi.org/10.1101/172478

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