NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani; Xin D. Gao; Pengpeng Liu; Ankit Gupta; Alireza Edraki; Raed Ibraheim; Kanae E. Sasaki; Lihua Julie Zhu; Scot A. Wolfe; Erik J. Sontheimer

doi:10.1101/172650

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NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani, Xin D. Gao, Pengpeng Liu, Ankit Gupta, Alireza Edraki, Raed Ibraheim, Kanae E. Sasaki, View ORCID ProfileLihua Julie Zhu, Scot A. Wolfe, View ORCID ProfileErik J. Sontheimer

doi: https://doi.org/10.1101/172650

Nadia Amrani

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Xin D. Gao

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Pengpeng Liu

3Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Ankit Gupta

3Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Alireza Edraki

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Raed Ibraheim

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Kanae E. Sasaki

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Lihua Julie Zhu

2Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

3Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

5Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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ORCID record for Lihua Julie Zhu

Scot A. Wolfe

3Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

4Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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Erik J. Sontheimer

1RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

2Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.

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ORCID record for Erik J. Sontheimer
For correspondence: erik.sontheimer@umassmed.edu

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Posted August 04, 2017.

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NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani, Xin D. Gao, Pengpeng Liu, Ankit Gupta, Alireza Edraki, Raed Ibraheim, Kanae E. Sasaki, Lihua Julie Zhu, Scot A. Wolfe, Erik J. Sontheimer

bioRxiv 172650; doi: https://doi.org/10.1101/172650

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NmeCas9 is an intrinsically high-fidelity genome editing platform

Nadia Amrani, Xin D. Gao, Pengpeng Liu, Ankit Gupta, Alireza Edraki, Raed Ibraheim, Kanae E. Sasaki, Lihua Julie Zhu, Scot A. Wolfe, Erik J. Sontheimer

bioRxiv 172650; doi: https://doi.org/10.1101/172650

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