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Human hippocampal replay during rest prioritizes weakly-learned information and predicts memory performance

View ORCID ProfileAnna C. Schapiro, View ORCID ProfileElizabeth A. McDevitt, Timothy T. Rogers, View ORCID ProfileSara C. Mednick, View ORCID ProfileKenneth A. Norman
doi: https://doi.org/10.1101/173021
Anna C. Schapiro
Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA
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  • For correspondence: aschapir@bidmc.harvard.edu
Elizabeth A. McDevitt
Department of Psychology, University of California-Riverside, Riverside, CA
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Timothy T. Rogers
Department of Psychology, University of Wisconsin-Madison, Madison, WI
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Sara C. Mednick
Department of Psychology, University of California-Riverside, Riverside, CA
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Kenneth A. Norman
Princeton Neuroscience Institute and Department of Psychology, Princeton University, Princeton, NJ
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Abstract

There is now extensive evidence that the hippocampus replays experiences during quiet rest periods, and that this replay benefits subsequent memory. A critical open question is how memories are prioritized for replay during these offline periods. We addressed this question in an experiment in which participants learned the features of 15 objects and then underwent fMRI scanning to track item-level replay in the hippocampus using pattern analysis during a rest period. Objects that were remembered less well were replayed more during the subsequent rest period, suggesting a prioritization process in which weaker memories—memories most vulnerable to forgetting—are selected for wake replay. Participants came back for a second session, either after a night of sleep or a day awake, and underwent another scanned rest period followed by a second memory test. In the second session, more hippocampal replay of a satellite during the rest period predicted better subsequent memory for that satellite. Only in the group with intervening sleep did rest replay predict improvement from the first to second session. Our results provide the first evidence that replay of individual memories occurs during rest in the human hippocampus and that this replay prioritizes weakly learned information, predicts subsequent memory performance, and relates to memory improvement across a delay with sleep.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 06, 2017.
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Human hippocampal replay during rest prioritizes weakly-learned information and predicts memory performance
Anna C. Schapiro, Elizabeth A. McDevitt, Timothy T. Rogers, Sara C. Mednick, Kenneth A. Norman
bioRxiv 173021; doi: https://doi.org/10.1101/173021
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Human hippocampal replay during rest prioritizes weakly-learned information and predicts memory performance
Anna C. Schapiro, Elizabeth A. McDevitt, Timothy T. Rogers, Sara C. Mednick, Kenneth A. Norman
bioRxiv 173021; doi: https://doi.org/10.1101/173021

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