New Results
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, David CM Liewald, Judith A Okely, Ari V Ahola-Olli, Catriona LK Barnes, Lars Bertram, Joshua C Bis, Katherine E Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E Gustavson, Caroline Hayward, Edith Hofer, M Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A Smith, Albert V Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J van der Lee, Erin B Ware, Beverly G Windham, Margaret J Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A Andreassen, Nicola Armstrong, John R Attia, Deborah Attix, Dimitrios Avramopoulos, David A Bennett, Anne C Böhmer, Patricia A Boyle, Henry Brodaty, Harry Campbell, Tyrone D Cannon, Elizabeth T Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R Cox, Anders M Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G Eriksson, Evangelos Evangelou, Jessica D Faul, Ian Ford, Nelson A Freimer, He Gao, Ina Giegling, Nathan A Gillespie, Scott D Gordon, Rebecca F Gottesman, Michael E Griswold, Vilmundur Gudnason, Tamara B Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G Holliday, Peter K Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S Knopman, Nicole Kochan, Bettina Konte, John B Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T Longstreth Jr, Oscar L Lopez, Anu Loukola, Tobias Luck, Astri J Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G Martin, Grant W Montgomery, Alison D Murray, Anna C Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A Poldrack, Bruce M Psaty, Steffi G Riedel-Heller, Richard J Rose, Jerome I Rotter, Panos Roussos, Suvi P Rovio, Yasaman Saba, Fred W Sabb, Perminder S Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J Scott, Matthew A Scult, Jeannette Simino, P Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C Stefanis, David J Stott, Richard E Straub, Kjetil Sundet, Adele M Taylor, Kent D Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab HH Adams, Dan E Arking, Robert M Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L Fitzpatrick, Michael Gill, David C Glahn, Sara Hägg, Narelle K Hansell, Ahmad R Hariri, M Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C Keller, William S Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L Pedersen, Neil Pendleton, David J Porteous, Katri Räikkönen, Olli T Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W Schofield, Peter R Schofield, John M Starr, Vidar M Steen, Julian N Trollor, Steven T Turner, Cornelia M Van Duijn, Arno Villringer, Daniel R Weinberger, David R Weir, James F Wilson, Anil Malhotra, Andrew M McIntosh, Catharine R Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J Deary
doi: https://doi.org/10.1101/176511
Gail Davies
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Max Lam
Institute of Mental Health, Singapore
Sarah E Harris
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKMedical Genetics Section, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
Joey W Trampush
BrainWorkup, LLC, Los Angeles, CA
Michelle Luciano
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
W David Hill
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Saskia P Hagenaars
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKMRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
Stuart J Ritchie
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Riccardo E Marioni
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKMedical Genetics Section, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
Chloe Fawns-Ritchie
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
David CM Liewald
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Judith A Okely
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Ari V Ahola-Olli
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandDepartment of Internal Medicine, Satakunta Central Hospital, Pori, Finland
Catriona LK Barnes
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Lars Bertram
Max Planck Institute for Molecular Genetics, Berlin, Germany
Joshua C Bis
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Katherine E Burdick
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USAMental Illness Research, Education, and Clinical Center (VISN 3), James J. Peters VA Medical Center, Bronx, NY, USADepartment of Psychiatry, Brigham and Women’s Hospital; Harvard Medical School, Boston, MA USA
Andrea Christoforou
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Pamela DeRosse
Institute of Mental Health, SingaporeCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
Srdjan Djurovic
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDepartment of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway
Thomas Espeseth
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, Norway
Stella Giakoumaki
Department of Psychology, University of Crete, Greece
Sudheer Giddaluru
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Daniel E Gustavson
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA
Caroline Hayward
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UKGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Edith Hofer
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, AustriaInstitute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria
M Arfan Ikram
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
Robert Karlsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Emma Knowles
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Jari Lahti
Institute of Behavioural Sciences, University of Helsinki, Helsinki, FinlandHelsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
Markus Leber
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Shuo Li
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Karen A Mather
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
Ingrid Melle
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Derek Morris
Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Ireland
Christopher Oldmeadow
Medical Research Institute and Faculty of Health, University of Newcastle, New South Wales, Australia
Teemu Palviainen
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Antony Payton
Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester
Raha Pazoki
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK
Katja Petrovic
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria
Chandra A Reynolds
Department of Psychology, University of California Riverside, Riverside, CA, USA
Muralidharan Sargurupremraj
University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, France
Markus Scholz
Institute for Medical Informatics, Statistics and Epidemiology, University of LeipzigLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig
Jennifer A Smith
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104
Albert V Smith
Icelandic Heart Association, Kopavogur, IcelandUniversity of Iceland, Reykjavik, Iceland
Natalie Terzikhan
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Respiratory Medicine, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
Anbu Thalamuthu
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, Australia
Stella Trompet
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Sven J van der Lee
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Erin B Ware
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104
Beverly G Windham
Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS
Margaret J Wright
Queensland Brain Institute, University of Queensland, Brisbane, AustraliaCentre for Advanced Imaging, University of Queensland, Brisbane, Australia
Jingyun Yang
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USADepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Jin Yu
Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA
David Ames
National Ageing Research Institute, Royal Melbourne Hospital, Victoria, AustraliaAcademic Unit for Psychiatry of Old Age, University of Melbourne, St George’s Hospital, Kew, Australia
Najaf Amin
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Philippe Amouyel
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - LabEx DISTALZ, F-59000 Lille, FranceDepartment of Epidemiology and Public Health, University Hospital of Lille, FranceINSERM-U1167, F-59019 Lille, France
Ole A Andreassen
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Nicola Armstrong
School of Mathematics and Statistics, University of Sydney, Sydney, Australia
John R Attia
Hunter Medical Research Institute and Faculty of Health University of Newcastle, New South Wales, Australia
Deborah Attix
Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USAPsychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA
Dimitrios Avramopoulos
Department of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, USADepartment of Psychiatry and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
David A Bennett
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USADepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
Anne C Böhmer
Institute of Human Genetics, University of Bonn, Bonn, GermanyDepartment of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
Patricia A Boyle
Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USADepartments of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA
Henry Brodaty
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaDementia Centre for Research Collaboration, University of New South Wales, Sydney, NSW, Australia
Harry Campbell
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Tyrone D Cannon
Department of Psychology, Yale University, New Haven, CT, USA
Elizabeth T Cirulli
Human Longevity Inc, Durham, NC, USA
Eliza Congdon
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Emily Drabant Conley
23andMe, Inc., Mountain View, CA, USA
Janie Corley
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Simon R Cox
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Anders M Dale
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USADepartment of Cognitive Science, University of California, San Diego, La Jolla, CA, USADepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USADepartment of Radiology, University of California, San Diego, La Jolla, CA, USA
Abbas Dehghan
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UKMRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, W2 1PG, UK
Danielle Dick
Department of Psychology, Virginia Commonwealth University, VA, USA
Dwight Dickinson
Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
Johan G Eriksson
National Institute for Health and Welfare, Helsinki, FinlandDepartment of General Practice and Primary Health Care, University of Helsinki, Helsinki, FinlandHelsinki University Central Hospital, Unit of General Practice, Helsinki, FinlandFolkhälsan Research Centre, Helsinki, Finland
Evangelos Evangelou
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UKNational Institute for Health and Welfare, Helsinki, Finland
Jessica D Faul
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104
Ian Ford
Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom
Nelson A Freimer
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
He Gao
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UK
Ina Giegling
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Nathan A Gillespie
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA
Scott D Gordon
QIMR Berghofer Medical Research Institute, Brisbane, Australia
Rebecca F Gottesman
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MDDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
Michael E Griswold
Department of Data Science, University of Mississippi Medical Center, Jackson, MS
Vilmundur Gudnason
Icelandic Heart Association, Kopavogur, IcelandUniversity of Iceland, Reykjavik, Iceland
Tamara B Harris
Intramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA
Alex Hatzimanolis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, GreeceNeurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Gerardo Heiss
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC
Elizabeth G Holliday
Hunter Medical Research Institute and Faculty of Health University of Newcastle, New South Wales, Australia
Peter K Joshi
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Mika Kähönen
Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center, Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33521, FinlandDepartment of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Sharon LR Kardia
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109
Ida Karlsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Luca Kleineidam
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
David S Knopman
Department of Neurology, Mayo Clinic, Rochester, MN
Nicole Kochan
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaNeuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
Bettina Konte
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
John B Kwok
Neuroscience Research Australia, Randwick, New South Wales, AustraliaSchool of Medical Sciences, University of New South Wales, Sydney, Australia
Stephanie Le Hellard
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Teresa Lee
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaNeuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
Terho Lehtimäki
Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, FinlandDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Shu-Chen Li
Max Planck Institute for Human Development, Berlin, GermanyTechnische Universität Dresden, Dresden, Germany
Tian Liu
Max Planck Institute for Molecular Genetics, Berlin, GermanyMax Planck Institute for Human Development, Berlin, Germany
Marisa Koini
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria
Edythe London
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Will T Longstreth
Department of Neurology, School of Medicine, University of Washington, Seattle, Washington, USADepartment of Epidemiology, University of Washington, Seattle, Washington, USA
Oscar L Lopez
Department of Neurology and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Anu Loukola
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Tobias Luck
Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of LeipzigLIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig
Astri J Lundervold
Department of Biological and Medical Psychology, University of Bergen, NorwayNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Anders Lundquist
Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SwedenDepartment of Statistics, USBE Umeå University, S-907 97 Umeå, Sweden
Leo-Pekka Lyytikäinen
Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, FinlandDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Nicholas G Martin
QIMR Berghofer Medical Research Institute, Brisbane, Australia
Grant W Montgomery
QIMR Berghofer Medical Research Institute, Brisbane, AustraliaInstitute for Molecular Bioscience, University of Queensland, Brisbane, Australia
Alison D Murray
The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, AB25 2ZD, UKGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Anna C Need
Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
Raymond Noordam
Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Lars Nyberg
Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SwedenDepartment of Radiation Sciences, Umeå University, SwedenDepartment of Integrative Medical Biology, Umeå University, Sweden
William Ollier
Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Goran Papenberg
Max Planck Institute for Human Development, Berlin, GermanyKarolinska Institutet, Aging Research Center, Stockholm University, Stockholm, Sweden
Alison Pattie
Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Ozren Polasek
Faculty of Medicine, University of Split, Split, Croatia
Russell A Poldrack
Department of Psychology, Stanford University, Palo Alto, CA, USA
Bruce M Psaty
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USADeparment of Health Services, University of Washington, Seattle, Washington, USAKaiser Permanente Washington Health Research Institute, Seattle, Washington, USA
Steffi G Riedel-Heller
Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig
Richard J Rose
Department of Psychological and Brain Sciences, Indiana University, Indiana, USA
Jerome I Rotter
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA
Panos Roussos
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USAMental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
Suvi P Rovio
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Yasaman Saba
Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz
Fred W Sabb
Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA
Perminder S Sachdev
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaNeuropsychiatric Institute, Prince of Wales Hospital, Sydney, Australia
Claudia Satizabal
Department of Neurology, Boston University School of Medicine
Matthias Schmid
Department of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
Rodney J Scott
Hunter Medical Research Institute and Faculty of Health University of Newcastle, New South Wales, Australia
Matthew A Scult
Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Jeannette Simino
Department of Data Science, University of Mississippi Medical Center, Jackson, MS
P Eline Slagboom
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
Nikolaos Smyrnis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, Greece
Aïcha Soumaré
University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, France
Nikos C Stefanis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, GreeceNeurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
David J Stott
Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
Richard E Straub
Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Kjetil Sundet
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayDepartment of Psychology, University of Oslo, Oslo, Norway
Adele M Taylor
Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Kent D Taylor
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical CenterDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA
Ioanna Tzoulaki
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UKMRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, W2 1PG, UKDepartment of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
Christophe Tzourio
University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, FranceDepartment of Public Health, University Hospital of Bordeaux, France
André Uitterlinden
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Veronique Vitart
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Aristotle N Voineskos
Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Eero Vuoksimaa
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandDepartment of Public Health, University of Helsinki, Helsinki, Finland
Michael Wagner
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, GermanyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
Holger Wagner
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
Leonie Weinhold
Department of Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
K Hoyan Wen
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Elisabeth Widen
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Qiong Yang
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
Wei Zhao
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109
Hieab HH Adams
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Radiology, Erasmus MC, Rotterdam, The Netherlands
Dan E Arking
Department of Psychiatry and McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Robert M Bilder
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Panos Bitsios
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Eric Boerwinkle
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TXHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX
Ornit Chiba-Falek
Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
Aiden Corvin
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Philip L De Jager
Center for Translational and Systems Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USAProgram in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
Stéphanie Debette
University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, FranceDepartment of Neurology, University Hospital of Bordeaux, France
Gary Donohoe
Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Ireland
Paul Elliott
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, W2 1PG, UKMRC-PHE Centre for Environment, School of Public Health, Imperial College London, London, W2 1PG, UK
Annette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, Washington, USADepartment of Global Health, University of Washington, Seattle, Washington, USA
Michael Gill
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
David C Glahn
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Sara Hägg
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Narelle K Hansell
Queensland Brain Institute, University of Queensland, Brisbane, Australia
Ahmad R Hariri
Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
M Kamran Ikram
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The NetherlandsDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands
J. Wouter Jukema
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Jaakko Kaprio
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandNational Institute for Health and Welfare, Helsinki, FinlandDepartment of Public Health, University of Helsinki, Helsinki, Finland
Matthew C Keller
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
William S Kremen
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USACenter for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA, USA
Lenore Launer
Intramural Research Program National Institutes on Aging, National Institutes of Health, Bethesda, MD, USA
Ulman Lindenberger
Max Planck Institute for Human Development, Berlin, Germany
Aarno Palotie
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, FinlandWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UKDepartment of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland
Nancy L Pedersen
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Neil Pendleton
Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, United KingdomManchester Medical School, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, United Kingdom
David J Porteous
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKMedical Genetics Section, Centre for Genomic & Experimental Medicine, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UKGeneration Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh
Katri Räikkönen
Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
Olli T Raitakari
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FinlandDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
Alfredo Ramirez
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
Ivar Reinvang
Department of Psychology, University of Oslo, Oslo, Norway
Igor Rudan
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland
Dan Rujescu
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Reinhold Schmidt
Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Austria
Helena Schmidt
Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of GrazDepartment of Neurology, Medical University Graz, Austria
Peter W Schofield
School of Medicine and Public Health, University of Newcastle, New South Wales, Australia
Peter R Schofield
Neuroscience Research Australia, Sydney AustraliaFaculty of Medicine, University of New South Wales, Sydney Australia
John M Starr
Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UKCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Vidar M Steen
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Julian N Trollor
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, AustraliaDepartment of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, Australia
Steven T Turner
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
Cornelia M Van Duijn
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Arno Villringer
Max Planck Institute for Human Cognitive and Brain Sciences, LeipzigDay Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig
Daniel R Weinberger
Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
David R Weir
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI 48104
James F Wilson
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, ScotlandMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
Anil Malhotra
Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USADivision of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USADepartment of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York
Andrew M McIntosh
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKDivision of Psychiatry, University of Edinburgh, Edinburgh, UK
Catharine R Gale
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UKMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK
Sudha Seshadri
Department of Neurology, Boston University School of MedicineThe National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA, USA
Thomas Mosley
Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS
Jan Bressler
Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX
Todd Lencz
Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USADepartment of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York
Ian J Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, UK
Abstract
General cognitive function is a prominent human trait associated with many important life outcomes1,2, including longevity3. The substantial heritability of general cognitive function is known to be polygenic, but it has had little explication in terms of the contributing genetic variants4,5,6. Here, we combined cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N=280,360). We found 9,714 genome-wide significant SNPs (P<5 × 10−8) in 99 independent loci. Most showed clear evidence of functional importance. Among many novel genes associated with general cognitive function were SGCZ, ATXN1, MAPT, AUTS2, and P2RY6. Within the novel genetic loci were variants associated with neurodegenerative disorders, neurodevelopmental disorders, physical and psychiatric illnesses, brain structure, and BMI. Gene-based analyses found 536 genes significantly associated with general cognitive function; many were highly expressed in the brain, and associated with neurogenesis and dendrite gene sets. Genetic association results predicted up to 4% of general cognitive function variance in independent samples. There was significant genetic overlap between general cognitive function and information processing speed, as well as many health variables including longevity.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted August 17, 2017.
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, David CM Liewald, Judith A Okely, Ari V Ahola-Olli, Catriona LK Barnes, Lars Bertram, Joshua C Bis, Katherine E Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E Gustavson, Caroline Hayward, Edith Hofer, M Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A Smith, Albert V Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J van der Lee, Erin B Ware, Beverly G Windham, Margaret J Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A Andreassen, Nicola Armstrong, John R Attia, Deborah Attix, Dimitrios Avramopoulos, David A Bennett, Anne C Böhmer, Patricia A Boyle, Henry Brodaty, Harry Campbell, Tyrone D Cannon, Elizabeth T Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R Cox, Anders M Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G Eriksson, Evangelos Evangelou, Jessica D Faul, Ian Ford, Nelson A Freimer, He Gao, Ina Giegling, Nathan A Gillespie, Scott D Gordon, Rebecca F Gottesman, Michael E Griswold, Vilmundur Gudnason, Tamara B Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G Holliday, Peter K Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S Knopman, Nicole Kochan, Bettina Konte, John B Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T Longstreth Jr, Oscar L Lopez, Anu Loukola, Tobias Luck, Astri J Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G Martin, Grant W Montgomery, Alison D Murray, Anna C Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A Poldrack, Bruce M Psaty, Steffi G Riedel-Heller, Richard J Rose, Jerome I Rotter, Panos Roussos, Suvi P Rovio, Yasaman Saba, Fred W Sabb, Perminder S Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J Scott, Matthew A Scult, Jeannette Simino, P Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C Stefanis, David J Stott, Richard E Straub, Kjetil Sundet, Adele M Taylor, Kent D Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab HH Adams, Dan E Arking, Robert M Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L Fitzpatrick, Michael Gill, David C Glahn, Sara Hägg, Narelle K Hansell, Ahmad R Hariri, M Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C Keller, William S Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L Pedersen, Neil Pendleton, David J Porteous, Katri Räikkönen, Olli T Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W Schofield, Peter R Schofield, John M Starr, Vidar M Steen, Julian N Trollor, Steven T Turner, Cornelia M Van Duijn, Arno Villringer, Daniel R Weinberger, David R Weir, James F Wilson, Anil Malhotra, Andrew M McIntosh, Catharine R Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J Deary
bioRxiv 176511; doi: https://doi.org/10.1101/176511
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E Harris, Joey W Trampush, Michelle Luciano, W David Hill, Saskia P Hagenaars, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, David CM Liewald, Judith A Okely, Ari V Ahola-Olli, Catriona LK Barnes, Lars Bertram, Joshua C Bis, Katherine E Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E Gustavson, Caroline Hayward, Edith Hofer, M Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A Smith, Albert V Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J van der Lee, Erin B Ware, Beverly G Windham, Margaret J Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A Andreassen, Nicola Armstrong, John R Attia, Deborah Attix, Dimitrios Avramopoulos, David A Bennett, Anne C Böhmer, Patricia A Boyle, Henry Brodaty, Harry Campbell, Tyrone D Cannon, Elizabeth T Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R Cox, Anders M Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G Eriksson, Evangelos Evangelou, Jessica D Faul, Ian Ford, Nelson A Freimer, He Gao, Ina Giegling, Nathan A Gillespie, Scott D Gordon, Rebecca F Gottesman, Michael E Griswold, Vilmundur Gudnason, Tamara B Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G Holliday, Peter K Joshi, Mika Kähönen, Sharon LR Kardia, Ida Karlsson, Luca Kleineidam, David S Knopman, Nicole Kochan, Bettina Konte, John B Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T Longstreth Jr, Oscar L Lopez, Anu Loukola, Tobias Luck, Astri J Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G Martin, Grant W Montgomery, Alison D Murray, Anna C Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A Poldrack, Bruce M Psaty, Steffi G Riedel-Heller, Richard J Rose, Jerome I Rotter, Panos Roussos, Suvi P Rovio, Yasaman Saba, Fred W Sabb, Perminder S Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J Scott, Matthew A Scult, Jeannette Simino, P Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C Stefanis, David J Stott, Richard E Straub, Kjetil Sundet, Adele M Taylor, Kent D Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab HH Adams, Dan E Arking, Robert M Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L Fitzpatrick, Michael Gill, David C Glahn, Sara Hägg, Narelle K Hansell, Ahmad R Hariri, M Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C Keller, William S Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L Pedersen, Neil Pendleton, David J Porteous, Katri Räikkönen, Olli T Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W Schofield, Peter R Schofield, John M Starr, Vidar M Steen, Julian N Trollor, Steven T Turner, Cornelia M Van Duijn, Arno Villringer, Daniel R Weinberger, David R Weir, James F Wilson, Anil Malhotra, Andrew M McIntosh, Catharine R Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J Deary
bioRxiv 176511; doi: https://doi.org/10.1101/176511
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