New Results
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E. Harris, Joey Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloë Fawns-Ritchie, David C. Liewald, Judith Okely, Ari Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, Beverly G. Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola Armstrong, John R. Attia, Deborah Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Böhmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R. Cox, Anders M. Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G. Eriksson, Evangelos Evangelou, Jessica D. Faul, Ian Ford, Nelson A. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael E. Griswold, Vilmundur Gudnason, Tamara B. Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G. Holliday, Peter K. Joshi, Mika Kähönen, Sharon L. R. Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole Kochan, Bettina Konte, John B. Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T. Longstreth Jr., Oscar L. Lopez, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G. Martin, Grant W. Montgomery, Alison D. Murray, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A. Poldrack, Bruce M. Psaty, Steffi G. Riedel-Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele M. Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N. Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K. Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab H. H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L. De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hägg, Narelle K. Hansell, Ahmad Hariri, M. Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C. Keller, William S. Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Räikkönen, Olli Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. Van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil Malhotra, Andrew M. McIntosh, Catharine R. Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J. Deary
doi: https://doi.org/10.1101/176511
Gail Davies
The University of Edinburgh;
Max Lam
Institute of Mental Health, Singapore;
Sarah E. Harris
The University of Edinburgh;
Joey Trampush
BrainWorkup, LLC, Los Angeles;
Michelle Luciano
The University of Edinburgh;
W. David Hill
The University of Edinburgh;
Saskia P. Hagenaars
King's College London;
Stuart J. Ritchie
The University of Edinburgh;
Riccardo E. Marioni
The University of Edinburgh;
Chloë Fawns-Ritchie
The University of Edinburgh;
David C. Liewald
The University of Edinburgh;
Judith Okely
The University of Edinburgh;
Ari Ahola-Olli
University of Turku;
Catriona L. K. Barnes
University of Edinburgh;
Lars Bertram
Max Planck Institute for Molecular Genetics;
Joshua C. Bis
University of Washington;
Katherine E. Burdick
Harvard Medical School;
Andrea Christoforou
University of Bergen;
Pamela DeRosse
Institute of Mental Health, Singapore;
Srdjan Djurovic
University of Bergen;
Thomas Espeseth
Oslo University Hospital;
Stella Giakoumaki
University of Crete;
Sudheer Giddaluru
University of Bergen;
Daniel E. Gustavson
University of California San Diego;
Caroline Hayward
University of Edinburgh;
Edith Hofer
Medical University Graz;
M. Arfan Ikram
Erasmus University Medical Center;
Robert Karlsson
Karolinska Institutet;
Emma Knowles
Yale University School of Medicine;
Jari Lahti
University of Helsinki;
Markus Leber
University of Cologne;
Shuo Li
Boston University School of Public Health;
Karen A. Mather
University of New South Wales;
Ingrid Melle
University of Bergen;
Derek Morris
Trinity College Dublin;
Christopher Oldmeadow
University of Newcastle;
Teemu Palviainen
University of Helsinki;
Antony Payton
The University of Manchester;
Raha Pazoki
Imperial College London;
Katja Petrovic
Medical University Graz;
Chandra A. Reynolds
University of California Riverside;
Muralidharan Sargurupremraj
University of Bordeaux;
Markus Scholz
University of Leipzig;
Jennifer A. Smith
University of Michigan;
Albert V. Smith
Icelandic Heart Association;
Natalie Terzikhan
Ghent University Hospital;
Anbu Thalamuthu
University of New South Wales;
Stella Trompet
Leiden University Medical Center;
Sven J. van der Lee
Erasmus University Medical Center;
Erin B. Ware
University of Michigan;
Beverly G. Windham
University of Mississippi Medical Center;
Margaret J. Wright
University of Queensland;
Jingyun Yang
Rush University Medical Center;
Jin Yu
Feinstein Institute for Medical Research;
David Ames
National Ageing Research Institute Royal Melbourne Hospital;
Najaf Amin
Erasmus University Medical Center;
Philippe Amouyel
Institut Pasteur de Lille;
Ole A. Andreassen
University of Oslo;
Nicola Armstrong
University of Sydney;
John R. Attia
University of Newcastle;
Deborah Attix
Duke University Medical Center;
Dimitrios Avramopoulos
Johns Hopkins University School of Medicine;
David A. Bennett
Rush University Medical Center;
Anne C. Böhmer
University of Bonn;
Patricia A. Boyle
Rush University Medical Center;
Henry Brodaty
University of New South Wales;
Harry Campbell
University of Edinburgh;
Tyrone D. Cannon
Yale University;
Elizabeth T. Cirulli
Human Longevity Inc, Durham, NC,;
Eliza Congdon
UCLA;
Emily Drabant Conley
23andMe, Inc.;
Janie Corley
The University of Edinburgh;
Simon R. Cox
The University of Edinburgh;
Anders M. Dale
University of California San Diego;
Abbas Dehghan
Imperial College London;
Danielle Dick
Virginia Commonwealth University;
Dwight Dickinson
National Institute of Health;
Johan G. Eriksson
National Institute for Health and Welfare, Helsinki;
Evangelos Evangelou
Imperial College London;
Jessica D. Faul
University of Michigan;
Ian Ford
University of Glasgow;
Nelson A. Freimer
UCLA;
He Gao
Imperial College London;
Ina Giegling
Martin Luther University of Halle-Wittenberg;
Nathan A. Gillespie
Virginia Commonwealth University;
Scott D. Gordon
QIMR Berghofer Medical Research Institute, Brisbane;
Rebecca F. Gottesman
Johns Hopkins University School of Medicine;
Michael E. Griswold
University of Mississippi Medical Center;
Vilmundur Gudnason
Icelandic Heart Association;
Tamara B. Harris
National Institutes of Health, Bethesda;
Alex Hatzimanolis
National and Kapodistrian University of Athens Medical School;
Gerardo Heiss
University of North Carolina;
Elizabeth G. Holliday
University of Newcastle;
Peter K. Joshi
University of Edinburgh;
Mika Kähönen
University of Tampere;
Sharon L. R. Kardia
University of Michigan;
Ida Karlsson
Karolinska Institutet;
Luca Kleineidam
University of Bonn;
David S. Knopman
Mayo Clinic, Rochester;
Nicole Kochan
University of New South Wales;
Bettina Konte
Martin Luther University of Halle-Wittenberg;
John B. Kwok
Neuroscience Research Australia;
Stephanie Le Hellard
University of Bergen;
Teresa Lee
University of New South Wales;
Terho Lehtimäki
University of Tampere;
Shu-Chen Li
Max Planck Institute for Human Development, Berlin;
Tian Liu
Max Planck Institute for Human Development, Berlin;
Marisa Koini
Medical University Graz;
Edythe London
UCLA;
Will T. Longstreth
University of Washington;
Oscar L. Lopez
University of Pittsburgh;
Anu Loukola
University of Helsinki;
Tobias Luck
University of Leipzig;
Astri J. Lundervold
University of Bergen;
Anders Lundquist
Umea University;
Leo-Pekka Lyytikäinen
University of Tampere;
Nicholas G. Martin
QIMR Berghofer Medical Research Institute;
Grant W. Montgomery
QIMR Berghofer Medical Research Institute;
Alison D. Murray
University of Aberdeen;
Anna C. Need
Imperial College, London;
Raymond Noordam
Leiden University Medical Center;
Lars Nyberg
Umea University;
William Ollier
University of Manchester;
Goran Papenberg
Max Planck Institute for Human Development, Berlin;
Alison Pattie
The University of Edinburgh;
Ozren Polasek
University of Split;
Russell A. Poldrack
Stanford University;
Bruce M. Psaty
University of Washington;
Steffi G. Riedel-Heller
University of Leipzig;
Richard J. Rose
Indiana University;
Jerome I. Rotter
UCLA;
Panos Roussos
Icahn School of Medicine at Mount Sinai;
Suvi Rovio
University of Turku;
Yasaman Saba
Medical University of Graz;
Fred W. Sabb
University of Oregon;
Perminder S. Sachdev
University of New South Wales;
Claudia Satizabal
Boston University School of Medicine;
Matthias Schmid
University of Bonn;
Rodney J. Scott
University of Newcastle;
Matthew A. Scult
Duke University;
Jeannette Simino
University of Mississippi Medical Center;
P. Eline Slagboom
Leiden University Medical Center;
Nikolaos Smyrnis
National and Kapodistrian University of Athens Medical School;
Aïcha Soumaré
University of Bordeaux;
Nikos C. Stefanis
National and Kapodistrian University of Athens Medical School;
David J. Stott
University of Glasgow;
Richard E. Straub
Johns Hopkins University Medical Campus, Baltimore;
Kjetil Sundet
Oslo University Hospital;
Adele M. Taylor
The University of Edinburgh;
Kent D. Taylor
Los Angeles Biomedical Research Institute;
Ioanna Tzoulaki
Imperial College London;
Christophe Tzourio
University of Bordeaux;
André Uitterlinden
Erasmus University Medical Center;
Veronique Vitart
University of Edinburgh;
Aristotle N. Voineskos
University of Toronto;
Eero Vuoksimaa
University of Helsinki;
Michael Wagner
University of Bonn;
Holger Wagner
University of Bonn;
Leonie Weinhold
University of Bonn;
K. Hoyan Wen
Erasmus University Medical Center;
Elisabeth Widen
University of Helsinki;
Qiong Yang
Boston University School of Public Health;
Wei Zhao
University of Michigan;
Hieab H. H. Adams
Erasmus MC;
Dan E. Arking
Johns Hopkins University School of Medicine;
Robert M. Bilder
UCLA;
Panos Bitsios
University of Crete;
Eric Boerwinkle
University of Texas Health Science Center at Houston;
Ornit Chiba-Falek
Duke University Medical Center;
Aiden Corvin
Trinity College Dublin;
Philip L. De Jager
Columbia University Medical Center;
Stéphanie Debette
University of Bordeaux;
Gary Donohoe
National University of Ireland, Galway;
Paul Elliott
Imperial College London;
Annette L. Fitzpatrick
University of Washington;
Michael Gill
Trinity College Dublin;
David C. Glahn
Yale University School of Medicine;
Sara Hägg
Karolinska Institutet;
Narelle K. Hansell
QIMR Berghofer Medical Research Institute;
Ahmad Hariri
Duke University;
M. Kamran Ikram
Erasmus University Medical Center;
J. Wouter Jukema
Leiden University Medical Center;
Jaakko Kaprio
University of Helsinki;
Matthew C. Keller
University of Colorado;
William S. Kremen
University of California San Diego;
Lenore Launer
National Institutes of Health, Bethesda;
Ulman Lindenberger
Max Planck Institute for Human Development, Berlin;
Aarno Palotie
University of Helsinki;
Nancy L. Pedersen
Karolinska Institutet;
Neil Pendleton
University of Manchester;
David J. Porteous
The University of Edinburgh;
Katri Räikkönen
University of Helsinki;
Olli Raitakari
University of Turku;
Alfredo Ramirez
University of Bonn;
Ivar Reinvang
University of Oslo;
Igor Rudan
The University of Edinburgh;
Dan Rujescu
Martin Luther University of Halle-Wittenberg;
Reinhold Schmidt
Medical University Graz;
Helena Schmidt
Medical University Graz;
Peter W. Schofield
University of Newcastle;
Peter R. Schofield
Neuroscience Research Australia;
John M. Starr
The University of Edinburgh;
Vidar M. Steen
University of Bergen;
Julian N. Trollor
University of New South Wales;
Steven T. Turner
Mayo Clinic, Rochester;
Cornelia M. Van Duijn
Erasmus University Medical Center;
Arno Villringer
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig;
Daniel R. Weinberger
Johns Hopkins University Medical Campus;
David R. Weir
University of Michigan;
James F. Wilson
The University of Edinburgh;
Anil Malhotra
Zucker Hillside Hospital;
Andrew M. McIntosh
The University of Edinburgh;
Catharine R. Gale
The University of Edinburgh;
Sudha Seshadri
The National Heart, Lung, and Blood Institute's Framingham Heart Study
Thomas Mosley
University of Mississippi Medical Center;
Jan Bressler
University of Texas Health Science Center at Houston;
Todd Lencz
Feinstein Institute for Medical Research;
Ian J. Deary
The University of Edinburgh;
Abstract
General cognitive function is a prominent human trait associated with many important life outcomes including longevity. The substantial heritability of general cognitive function is known to be polygenic, but it has had little explication in terms of the contributing genetic variants. Here, we combined cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N=280,360). We found 9,714 genome-wide significant SNPs (P<5 x 10-8) in 99 independent loci. Most showed clear evidence of functional importance. Among many novel genes associated with general cognitive function were SGCZ, ATXN1, MAPT, AUTS2, and P2RY6. Within the novel genetic loci were variants associated with neurodegenerative disorders, neurodevelopmental disorders, physical and psychiatric illnesses, brain structure, and BMI. Gene-based analyses found 536 genes significantly associated with general cognitive function; many were highly expressed in the brain, and associated with neurogenesis and dendrite gene sets. Genetic association results predicted up to 4% of general cognitive function variance in independent samples. There was significant genetic overlap between general cognitive function and information processing speed, as well as many health variables including longevity.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted August 17, 2017.
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E. Harris, Joey Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloë Fawns-Ritchie, David C. Liewald, Judith Okely, Ari Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, Beverly G. Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola Armstrong, John R. Attia, Deborah Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Böhmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R. Cox, Anders M. Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G. Eriksson, Evangelos Evangelou, Jessica D. Faul, Ian Ford, Nelson A. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael E. Griswold, Vilmundur Gudnason, Tamara B. Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G. Holliday, Peter K. Joshi, Mika Kähönen, Sharon L. R. Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole Kochan, Bettina Konte, John B. Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T. Longstreth Jr., Oscar L. Lopez, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G. Martin, Grant W. Montgomery, Alison D. Murray, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A. Poldrack, Bruce M. Psaty, Steffi G. Riedel-Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele M. Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N. Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K. Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab H. H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L. De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hägg, Narelle K. Hansell, Ahmad Hariri, M. Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C. Keller, William S. Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Räikkönen, Olli Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. Van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil Malhotra, Andrew M. McIntosh, Catharine R. Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J. Deary
bioRxiv 176511; doi: https://doi.org/10.1101/176511
Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)
Gail Davies, Max Lam, Sarah E. Harris, Joey Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloë Fawns-Ritchie, David C. Liewald, Judith Okely, Ari Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic, Thomas Espeseth, Stella Giakoumaki, Sudheer Giddaluru, Daniel E. Gustavson, Caroline Hayward, Edith Hofer, M. Arfan Ikram, Robert Karlsson, Emma Knowles, Jari Lahti, Markus Leber, Shuo Li, Karen A. Mather, Ingrid Melle, Derek Morris, Christopher Oldmeadow, Teemu Palviainen, Antony Payton, Raha Pazoki, Katja Petrovic, Chandra A. Reynolds, Muralidharan Sargurupremraj, Markus Scholz, Jennifer A. Smith, Albert V. Smith, Natalie Terzikhan, Anbu Thalamuthu, Stella Trompet, Sven J. van der Lee, Erin B. Ware, Beverly G. Windham, Margaret J. Wright, Jingyun Yang, Jin Yu, David Ames, Najaf Amin, Philippe Amouyel, Ole A. Andreassen, Nicola Armstrong, John R. Attia, Deborah Attix, Dimitrios Avramopoulos, David A. Bennett, Anne C. Böhmer, Patricia A. Boyle, Henry Brodaty, Harry Campbell, Tyrone D. Cannon, Elizabeth T. Cirulli, Eliza Congdon, Emily Drabant Conley, Janie Corley, Simon R. Cox, Anders M. Dale, Abbas Dehghan, Danielle Dick, Dwight Dickinson, Johan G. Eriksson, Evangelos Evangelou, Jessica D. Faul, Ian Ford, Nelson A. Freimer, He Gao, Ina Giegling, Nathan A. Gillespie, Scott D. Gordon, Rebecca F. Gottesman, Michael E. Griswold, Vilmundur Gudnason, Tamara B. Harris, Alex Hatzimanolis, Gerardo Heiss, Elizabeth G. Holliday, Peter K. Joshi, Mika Kähönen, Sharon L. R. Kardia, Ida Karlsson, Luca Kleineidam, David S. Knopman, Nicole Kochan, Bettina Konte, John B. Kwok, Stephanie Le Hellard, Teresa Lee, Terho Lehtimäki, Shu-Chen Li, Tian Liu, Marisa Koini, Edythe London, Will T. Longstreth Jr., Oscar L. Lopez, Anu Loukola, Tobias Luck, Astri J. Lundervold, Anders Lundquist, Leo-Pekka Lyytikäinen, Nicholas G. Martin, Grant W. Montgomery, Alison D. Murray, Anna C. Need, Raymond Noordam, Lars Nyberg, William Ollier, Goran Papenberg, Alison Pattie, Ozren Polasek, Russell A. Poldrack, Bruce M. Psaty, Steffi G. Riedel-Heller, Richard J. Rose, Jerome I. Rotter, Panos Roussos, Suvi Rovio, Yasaman Saba, Fred W. Sabb, Perminder S. Sachdev, Claudia Satizabal, Matthias Schmid, Rodney J. Scott, Matthew A. Scult, Jeannette Simino, P. Eline Slagboom, Nikolaos Smyrnis, Aïcha Soumaré, Nikos C. Stefanis, David J. Stott, Richard E. Straub, Kjetil Sundet, Adele M. Taylor, Kent D. Taylor, Ioanna Tzoulaki, Christophe Tzourio, André Uitterlinden, Veronique Vitart, Aristotle N. Voineskos, Eero Vuoksimaa, Michael Wagner, Holger Wagner, Leonie Weinhold, K. Hoyan Wen, Elisabeth Widen, Qiong Yang, Wei Zhao, Hieab H. H. Adams, Dan E. Arking, Robert M. Bilder, Panos Bitsios, Eric Boerwinkle, Ornit Chiba-Falek, Aiden Corvin, Philip L. De Jager, Stéphanie Debette, Gary Donohoe, Paul Elliott, Annette L. Fitzpatrick, Michael Gill, David C. Glahn, Sara Hägg, Narelle K. Hansell, Ahmad Hariri, M. Kamran Ikram, J. Wouter Jukema, Jaakko Kaprio, Matthew C. Keller, William S. Kremen, Lenore Launer, Ulman Lindenberger, Aarno Palotie, Nancy L. Pedersen, Neil Pendleton, David J. Porteous, Katri Räikkönen, Olli Raitakari, Alfredo Ramirez, Ivar Reinvang, Igor Rudan, Dan Rujescu, Reinhold Schmidt, Helena Schmidt, Peter W. Schofield, Peter R. Schofield, John M. Starr, Vidar M. Steen, Julian N. Trollor, Steven T. Turner, Cornelia M. Van Duijn, Arno Villringer, Daniel R. Weinberger, David R. Weir, James F. Wilson, Anil Malhotra, Andrew M. McIntosh, Catharine R. Gale, Sudha Seshadri, Thomas Mosley, Jan Bressler, Todd Lencz, Ian J. Deary
bioRxiv 176511; doi: https://doi.org/10.1101/176511
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