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RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment

Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Qihui Zhou, Tonatiuh Pena, Vincenzo Capece, Gaurav Jain, Susanne Burkhardt, Roman Stilling, Dieter Edbauer, Camin Dean, André Fischer
doi: https://doi.org/10.1101/178814
Eva Benito
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Cemil Kerimoglu
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
2Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Griesbachstr. 5, 37077 Göttingen, Germany
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Binu Ramachandran
3Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstr. 5, 37077 Goettingen, Germany
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Qihui Zhou
4German Center for Neurodegenerative Diseases (DZNE), Munich, Schillerstr. 44, 80336 Munich, Germany
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Tonatiuh Pena
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
5Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Vincenzo Capece
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
5Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Gaurav Jain
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
5Bioinformatics Unit, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Susanne Burkhardt
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Roman Stilling
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
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Dieter Edbauer
4German Center for Neurodegenerative Diseases (DZNE), Munich, Schillerstr. 44, 80336 Munich, Germany
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Camin Dean
3Trans-synaptic Signaling Group, European Neuroscience Institute, Grisebachstr. 5, 37077 Goettingen, Germany
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André Fischer
1Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, von Siebold Str. 3A, 37075 Göttingen, Germany
2Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Griesbachstr. 5, 37077 Göttingen, Germany
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ABSTRACT

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning & memory and lower the risk for various complex diseases including Alzheimer’s disease. Here we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that the effect is mediated through sperm RNA and is explained by microRNAs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific microRNAs as candidates mechanistically involved in this type of transmission.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 31, 2017.
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RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment
Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Qihui Zhou, Tonatiuh Pena, Vincenzo Capece, Gaurav Jain, Susanne Burkhardt, Roman Stilling, Dieter Edbauer, Camin Dean, André Fischer
bioRxiv 178814; doi: https://doi.org/10.1101/178814
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RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment
Eva Benito, Cemil Kerimoglu, Binu Ramachandran, Qihui Zhou, Tonatiuh Pena, Vincenzo Capece, Gaurav Jain, Susanne Burkhardt, Roman Stilling, Dieter Edbauer, Camin Dean, André Fischer
bioRxiv 178814; doi: https://doi.org/10.1101/178814

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