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Stable representation of sounds in the posterior striatum during flexible auditory decisions

View ORCID ProfileLan Guo, William I. Walker, Nicholas D. Ponvert, Phoebe L. Penix, View ORCID ProfileSantiago Jaramillo
doi: https://doi.org/10.1101/180505
Lan Guo
Institute of Neuroscience and Department of Biology. University of Oregon. Eugene, OR 97403
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William I. Walker
Institute of Neuroscience and Department of Biology. University of Oregon. Eugene, OR 97403
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Nicholas D. Ponvert
Institute of Neuroscience and Department of Biology. University of Oregon. Eugene, OR 97403
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Phoebe L. Penix
Institute of Neuroscience and Department of Biology. University of Oregon. Eugene, OR 97403
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Santiago Jaramillo
Institute of Neuroscience and Department of Biology. University of Oregon. Eugene, OR 97403
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Abstract

The neuronal pathways that link sounds to rewarded actions remain elusive. It is unclear whether neurons in the posterior tail of the dorsal striatum (which receive direct input from the auditory system) mediate action selection, as other striatal circuits do. Here, we examined the role of posterior striatal neurons in auditory decisions in mice. We found that, in contrast to the anterior dorsal striatum, activation of the posterior striatum did not elicit systematic movement. However, activation of posterior striatal neurons during sound presentation in an auditory discrimination task biased the animals’ choices, and transient inactivation of these neurons largely impaired sound discrimination. Moreover, the activity of these neurons reliably encoded stimulus features, but was only minimally influenced by the animals’ choices. Our results suggest that posterior striatal neurons play an essential role in auditory decisions, yet these neurons provide sensory information downstream rather than motor commands during well-learned sound-driven tasks.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted August 25, 2017.
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Stable representation of sounds in the posterior striatum during flexible auditory decisions
Lan Guo, William I. Walker, Nicholas D. Ponvert, Phoebe L. Penix, Santiago Jaramillo
bioRxiv 180505; doi: https://doi.org/10.1101/180505
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Stable representation of sounds in the posterior striatum during flexible auditory decisions
Lan Guo, William I. Walker, Nicholas D. Ponvert, Phoebe L. Penix, Santiago Jaramillo
bioRxiv 180505; doi: https://doi.org/10.1101/180505

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