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Germline loss of MBD4 predisposes to leukaemia due to a mutagenic cascade driven by 5mC
Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J.M. Valk, Ian J. Majewski
doi: https://doi.org/10.1101/180588
Mathijs A. Sanders
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Edward Chew
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
3Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Parkville, Australia
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
5Victorian Comprehensive Cancer Centre, Parkville, Australia
Christoffer Flensburg
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
Annelieke Zeilemaker
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Sarah E. Miller
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Adil S. al Hinai
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
6National Genetic Center, Royal Hospital, Ministry of Health, Sultanate of Oman
Ashish Bajel
3Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Parkville, Australia
5Victorian Comprehensive Cancer Centre, Parkville, Australia
Bram Luiken
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Melissa Rijken
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Tamara Mclennan
7Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Remco M. Hoogenboezem
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
François G. Kavelaars
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Marnie E. Blewitt
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
7Division of Molecular Medicine, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Eric M. Bindels
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Warren S. Alexander
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
Bob Löwenberg
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Andrew W. Roberts
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
3Department of Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Parkville, Australia
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
5Victorian Comprehensive Cancer Centre, Parkville, Australia
Peter J.M. Valk
1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Ian J. Majewski
2Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
4Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia
Article usage
Posted November 01, 2017.
Germline loss of MBD4 predisposes to leukaemia due to a mutagenic cascade driven by 5mC
Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J.M. Valk, Ian J. Majewski
bioRxiv 180588; doi: https://doi.org/10.1101/180588
Germline loss of MBD4 predisposes to leukaemia due to a mutagenic cascade driven by 5mC
Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J.M. Valk, Ian J. Majewski
bioRxiv 180588; doi: https://doi.org/10.1101/180588
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