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Alterations in neurovascular coupling following acute traumatic brain injury

Hyounguk Jang, Stanley Huang, Daniel X. Hammer, Lin Wang, Meijun Ye, Cristin G. Welle, Jonathan A. N. Fisher
doi: https://doi.org/10.1101/183129
Hyounguk Jang
Department of Physiology, New York Medical College, Valhalla, NY 10595;Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;
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Stanley Huang
Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;
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Daniel X. Hammer
Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;
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Lin Wang
Department of Physiology, New York Medical College, Valhalla, NY 10595;
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Meijun Ye
Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;
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Cristin G. Welle
Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;Departments of Neurosurgery and Bioengineering, University of Colorado Denver, Aurora, CO 80045
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Jonathan A. N. Fisher
Department of Physiology, New York Medical College, Valhalla, NY 10595;Division of Biomedical Physics, U.S. Food and Drug Administration, Silver Spring, MD 20993;
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Abstract

Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. A challenge for diagnosing and assessing the severity of TBI, however, is that quantitative biomarkers are lacking. We explored potential functional indicators for TBI by noninvasively monitoring sensory-evoked electrical and hemodynamic activity using a novel hybrid optical and electrophysiological measurement approach. By combining diffuse correlation spectroscopy with co-localized electrophysiological measurements in a mouse model of TBI, we observed concomitant alterations in somatosensory-evoked cerebral blood flow and electrical potentials following controlled cortical impact. Injury acutely reduced the amplitude of stimulus-evoked responses, which mostly recovered to baseline values within 30 min; intertrial variability for these parameters was also acutely altered. The kinetics of recovery, however, varied among specific components of the evoked waveforms, and we observed strong correlations between the two measurement modalities for only a select subset of waveform parameters. Overall, our results identify a novel set of potential biomarkers for TBI and demonstrate the utility of combined, noninvasive optical and electrophysiological measurements for detecting injury-induced abnormalities in neurovascular reactivity.

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Posted August 31, 2017.
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Alterations in neurovascular coupling following acute traumatic brain injury
Hyounguk Jang, Stanley Huang, Daniel X. Hammer, Lin Wang, Meijun Ye, Cristin G. Welle, Jonathan A. N. Fisher
bioRxiv 183129; doi: https://doi.org/10.1101/183129
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Alterations in neurovascular coupling following acute traumatic brain injury
Hyounguk Jang, Stanley Huang, Daniel X. Hammer, Lin Wang, Meijun Ye, Cristin G. Welle, Jonathan A. N. Fisher
bioRxiv 183129; doi: https://doi.org/10.1101/183129

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