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Temporal dissociation of salience and prediction error responses to appetitive and aversive taste

E. Hird, View ORCID ProfileW. El-Deredy, A. Jones, D. Talmi
doi: https://doi.org/10.1101/184341
E. Hird
1Division of Neuroscience and Experimental Psychology, University of Manchester, United Kingdom, M139GB
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W. El-Deredy
1Division of Neuroscience and Experimental Psychology, University of Manchester, United Kingdom, M139GB
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  • ORCID record for W. El-Deredy
A. Jones
1Division of Neuroscience and Experimental Psychology, University of Manchester, United Kingdom, M139GB
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D. Talmi
1Division of Neuroscience and Experimental Psychology, University of Manchester, United Kingdom, M139GB
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Abstract

The feedback-related negativity, a frontocentral event-related potential (ERP) occurring 200350 milliseconds (ms) after emotionally-valued outcomes, has been posited as the neural correlate of reward prediction error, a key component of associative learning. Recent evidence challenged this interpretation and has led to the suggestion that this ERP expresses salience, instead. Here we distinguish between utility prediction error and salience by delivering or withholding hedonistically matched appetitive and aversive tastes, and measure ERPs to cues signalling each taste. We observed a typical FRN (computed as the loss-minus-gain difference wave) to appetitive taste, but a reverse-FRN to aversive taste. When tested axiomatically, frontocentral ERPs showed a salience response across tastes, with a particularly early response to outcome delivery, supporting recent propositions of a fast, unsigned and unspecific response to salient stimuli. ERPs also expressed aversive prediction error peaking at 285ms, which conformed to the logic of an axiomatic model of prediction error. With stimuli that most resemble those used in animal models we did not detect any frontocentral ERP signal for utility prediction error, in contrast with dominant views of the functional role of the feedback-related negativity ERP. We link the animal and human literature and present a challenge for current perspectives on associative learning research using ERPs.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 07, 2017.
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Temporal dissociation of salience and prediction error responses to appetitive and aversive taste
E. Hird, W. El-Deredy, A. Jones, D. Talmi
bioRxiv 184341; doi: https://doi.org/10.1101/184341
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Temporal dissociation of salience and prediction error responses to appetitive and aversive taste
E. Hird, W. El-Deredy, A. Jones, D. Talmi
bioRxiv 184341; doi: https://doi.org/10.1101/184341

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