New Results
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
doi: https://doi.org/10.1101/184853
Jeanne E Savage
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Philip R Jansen
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
2Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
Sven Stringer
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Kyoko Watanabe
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Julien Bryois
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Christiaan A de Leeuw
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Mats Nagel
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Swapnil Awasthi
4Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
Peter B Barr
5Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
Jonathan R I Coleman
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
7NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Katrina L Grasby
8QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Anke R Hammerschlag
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Jakob Kaminski
4Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
9Berlin Institute of Health (BIH), 10178 Berlin, Germany
Robert Karlsson
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Eva Krapohl
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Max Lam
10Institute of Mental Health, Singapore
Marianne Nygaard
11The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark
12Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Chandra A Reynolds
13Department of Psychology, University of California Riverside, Riverside, CA, USA
Joey W Trampush
14BrainWorkup, LLC, Los Angeles, CA
Hannah Young
15Department of Psychology, University of Minnesota
Delilah Zabaneh
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Sara Hägg
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Narelle K Hansell
16Queensland Brain Institute, University of Queensland, Brisbane, Australia
Ida K Karlsson
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sten Linnarsson
17Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Grant W Montgomery
8QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
18Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia
Ana B Muñoz-Manchado
17Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Erin B Quinlan
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Gunter Schumann
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Nathan Skene
17Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Bradley T Webb
19Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
20Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
21Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
Tonya White
2Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
Dan E Arking
22McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Deborah K Attix
23Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
24Psychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA
Dimitrios Avramopoulos
25Department of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, USA
22McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Robert M Bilder
26UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Panos Bitsios
27Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Katherine E Burdick
28Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
29Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
30Department of Psychiatry - Brigham and Women’s Hospital; Harvard Medical School; Boston MA
Tyrone D Cannon
31Department of Psychology, Yale University, New Haven, CT, USA
Ornit Chiba-Falek
32Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
Andrea Christoforou
23Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Elizabeth T Cirulli
33Human Longevity Inc, Durham, NC, USA
Eliza Congdon
26UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Aiden Corvin
34Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Gail Davies
35Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
36Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Ian J Deary
35Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
36Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Pamela DeRosse
37Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Dwight Dickinson
38Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
Srdjan Djurovic
39Department of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway.
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Gary Donohoe
41Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Emily Drabant Conley
4223andMe, Inc., Mountain View, CA, USA
Johan G Eriksson
43Department of General Practice and Primary Health Care, University of Helsinki
44Helsinki University Hospital, Helsinki, Finland
Thomas Espeseth
45Department of Psychology, University of Oslo, Oslo, Norway
46Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Nelson A Freimer
26UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Stella Giakoumaki
47Department of Psychology, University of Crete, Greece
Ina Giegling
48Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Michael Gill
34Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
David C Glahn
49Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Ahmad R Hariri
50Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Alex Hatzimanolis
51Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
52University Mental Health Research Institute, Athens, Greece
53Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Matthew C Keller
54Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
Emma Knowles
49Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Bettina Konte
48Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Jari Lahti
55Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
56Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
Stephanie Le Hellard
23Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Todd Lencz
37Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
57Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York
58Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
David C Liewald
36Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Edythe London
26UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Astri J Lundervold
59Department of Biological and Medical Psychology, University of Bergen, Norway
Anil K Malhotra
37Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
57Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York
58Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
Ingrid Melle
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
46Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Derek Morris
41Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Anna C Need
60Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
William Ollier
61Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Aarno Palotie
62Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
63Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
64Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts
Antony Payton
65Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, United Kingdom
Neil Pendleton
66Division of Neuroscience and Experimental Psychology/ School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
Russell A Poldrack
67Department of Psychology, Stanford University, Palo Alto, CA, USA
Katri Räikkönen
68Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
Ivar Reinvang
45Department of Psychology, University of Oslo, Oslo, Norway
Panos Roussos
28Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
29Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
69Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Dan Rujescu
48Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Fred W Sabb
70Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA
Matthew A Scult
50Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Olav B Smeland
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
71Department of Neuroscience, University of California San Diego, La Jolla, California, USA
Nikolaos Smyrnis
51Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
52University Mental Health Research Institute, Athens, Greece
John M Starr
35Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
72Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
Vidar M Steen
23Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Nikos C Stefanis
51Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
52University Mental Health Research Institute, Athens, Greece
53Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Richard E Straub
73Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Kjetil Sundet
45Department of Psychology, University of Oslo, Oslo, Norway
46Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Aristotle N Voineskos
74Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Daniel R Weinberger
73Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Elisabeth Widen
62Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Jin Yu
37Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Goncalo Abecasis
76Center for Statistical Genetics, University of Michigan, Ann Arbor, USA
75Department of Biostatistics, University of Michigan, Ann Arbor, USA
Ole A Andreassen
40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
46Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
77Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Gerome Breen
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
7NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Lene Christiansen
11The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark
12Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Birgit Debrabant
12Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Danielle M Dick
5Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
21Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
78College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, USA
Andreas Heinz
4Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
Jens Hjerling-Leffler
17Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
M Arfan Ikram
79Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Kenneth S Kendler
19Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
20Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
21Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
Nicholas G Martin
8QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Sarah E Medland
8QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Nancy L Pedersen
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Robert Plomin
6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Tinca JC Polderman
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Stephan Ripke
4Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
80Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USA
81Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
Sophie van der Sluis
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Patrick F Sullivan
3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
82Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Henning Tiemeier
2Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
79Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Scott I Vrieze
15Department of Psychology, University of Minnesota
Margaret J Wright
16Queensland Brain Institute, University of Queensland, Brisbane, Australia
83Centre for Advanced Imaging, University of Queensland, Brisbane, Australia
Danielle Posthuma
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
84Department of Clinical Genetics, section Complex Trait Genetics, Neuroscience Campus Amsterdam, VU Medical Center, Amsterdam, the Netherlands
Abstract
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to intelligence3–7, but much about its genetic underpinnings remains to be discovered. Here, we present the largest genetic association study of intelligence to date (N=279,930), identifying 206 genomic loci (191 novel) and implicating 1,041 genes (963 novel) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and identify 89 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain and specifically in striatal medium spiny neurons and cortical and hippocampal pyramidal neurons. Gene-set analyses implicate pathways related to neurogenesis, neuron differentiation and synaptic structure. We confirm previous strong genetic correlations with several neuropsychiatric disorders, and Mendelian Randomization results suggest protective effects of intelligence for Alzheimer’s dementia and ADHD, and bidirectional causation with strong pleiotropy for schizophrenia. These results are a major step forward in understanding the neurobiology of intelligence as well as genetically associated neuropsychiatric traits.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted September 06, 2017.
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
bioRxiv 184853; doi: https://doi.org/10.1101/184853
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
bioRxiv 184853; doi: https://doi.org/10.1101/184853
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