New Results
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
doi: https://doi.org/10.1101/184853
Jeanne E Savage
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Philip R Jansen
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The NetherlandsDepartment of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
Sven Stringer
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Kyoko Watanabe
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Julien Bryois
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Christiaan A de Leeuw
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Mats Nagel
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Swapnil Awasthi
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
Peter B Barr
Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
Jonathan R I Coleman
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Katrina L Grasby
QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Anke R Hammerschlag
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Jakob Kaminski
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, GermanyBerlin Institute of Health (BIH), 10178 Berlin, Germany
Robert Karlsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Eva Krapohl
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Max Lam
Institute of Mental Health, Singapore
Marianne Nygaard
The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, DenmarkEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Chandra A Reynolds
Department of Psychology, University of California Riverside, Riverside, CA, USA
Joey W Trampush
BrainWorkup, LLC, Los Angeles, CA
Hannah Young
Department of Psychology, University of Minnesota
Delilah Zabaneh
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Sara Hägg
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Narelle K Hansell
Queensland Brain Institute, University of Queensland, Brisbane, Australia
Ida K Karlsson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sten Linnarsson
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Grant W Montgomery
QIMR Berghofer Medical Research Institute, Herston, Brisbane, AustraliaInstitute for Molecular Biosciences, University of Queensland, Brisbane, Australia
Ana B Muñoz-Manchado
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Erin B Quinlan
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Gunter Schumann
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Nathan Skene
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Bradley T Webb
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USADepartment of Psychiatry, Virginia Commonwealth University, Richmond, USADepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
Tonya White
Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
Dan E Arking
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Deborah K Attix
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, NorwayPsychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA
Dimitrios Avramopoulos
Department of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, USAMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
Robert M Bilder
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Panos Bitsios
Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
Katherine E Burdick
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USAMental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USADepartment of Psychiatry - Brigham and Women’s Hospital; Harvard Medical School; Boston MA
Tyrone D Cannon
Department of Psychology, Yale University, New Haven, CT, USA
Ornit Chiba-Falek
Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
Andrea Christoforou
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
Elizabeth T Cirulli
Human Longevity Inc, Durham, NC, USA
Eliza Congdon
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Aiden Corvin
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
Gail Davies
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United KingdomDepartment of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Ian J Deary
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United KingdomDepartment of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Pamela DeRosse
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Dwight Dickinson
Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
Srdjan Djurovic
Department of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway.NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Gary Donohoe
Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Emily Drabant Conley
23andMe, Inc., Mountain View, CA, USA
Johan G Eriksson
Department of General Practice and Primary Health Care, University of HelsinkiHelsinki University Hospital, Helsinki, Finland
Thomas Espeseth
Department of Psychology, University of Oslo, Oslo, NorwayDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Nelson A Freimer
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Stella Giakoumaki
Department of Psychology, University of Crete, Greece
Ina Giegling
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Michael Gill
Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
David C Glahn
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Ahmad R Hariri
Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Alex Hatzimanolis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, GreeceNeurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Matthew C Keller
Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
Emma Knowles
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Bettina Konte
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Jari Lahti
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, FinlandHelsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
Stephanie Le Hellard
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, NorwayNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Todd Lencz
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USADepartment of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New YorkCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
David C Liewald
Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
Edythe London
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
Astri J Lundervold
Department of Biological and Medical Psychology, University of Bergen, Norway
Anil K Malhotra
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USADepartment of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New YorkCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
Ingrid Melle
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Derek Morris
Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
Anna C Need
Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
William Ollier
Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, United Kingdom
Aarno Palotie
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, FinlandWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United KingdomMassachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts
Antony Payton
Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, United Kingdom
Neil Pendleton
Division of Neuroscience and Experimental Psychology/ School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
Russell A Poldrack
Department of Psychology, Stanford University, Palo Alto, CA, USA
Katri Räikkönen
Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
Ivar Reinvang
Department of Psychology, University of Oslo, Oslo, Norway
Panos Roussos
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USAMental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USADepartment of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Dan Rujescu
Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
Fred W Sabb
Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA
Matthew A Scult
Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
Olav B Smeland
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDepartment of Neuroscience, University of California San Diego, La Jolla, California, USA
Nikolaos Smyrnis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, Greece
John M Starr
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United KingdomAlzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
Vidar M Steen
Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, NorwayNORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
Nikos C Stefanis
Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, GreeceUniversity Mental Health Research Institute, Athens, GreeceNeurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
Richard E Straub
Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Kjetil Sundet
Department of Psychology, University of Oslo, Oslo, NorwayDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
Aristotle N Voineskos
Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
Daniel R Weinberger
Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
Elisabeth Widen
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
Jin Yu
Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
Goncalo Abecasis
Center for Statistical Genetics, University of Michigan, Ann Arbor, USADepartment of Biostatistics, University of Michigan, Ann Arbor, USA
Ole A Andreassen
NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, NorwayDivision of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, Norway
Gerome Breen
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UKNIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
Lene Christiansen
The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, DenmarkEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Birgit Debrabant
Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
Danielle M Dick
Department of Psychology, Virginia Commonwealth University, Richmond, VA, USADepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USACollege Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, USA
Andreas Heinz
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
Jens Hjerling-Leffler
Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
M Arfan Ikram
Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Kenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USADepartment of Psychiatry, Virginia Commonwealth University, Richmond, USADepartment of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
Nicholas G Martin
QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Sarah E Medland
QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
Nancy L Pedersen
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Robert Plomin
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Tinca JC Polderman
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Stephan Ripke
Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, GermanyAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USAStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
Sophie van der Sluis
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
Patrick F Sullivan
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SwedenDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA
Henning Tiemeier
Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
Scott I Vrieze
Department of Psychology, University of Minnesota
Margaret J Wright
Queensland Brain Institute, University of Queensland, Brisbane, AustraliaCentre for Advanced Imaging, University of Queensland, Brisbane, Australia
Danielle Posthuma
Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The NetherlandsDepartment of Clinical Genetics, section Complex Trait Genetics, Neuroscience Campus Amsterdam, VU Medical Center, Amsterdam, the Netherlands
Abstract
Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to intelligence3–7, but much about its genetic underpinnings remains to be discovered. Here, we present the largest genetic association study of intelligence to date (N=279,930), identifying 206 genomic loci (191 novel) and implicating 1,041 genes (963 novel) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and identify 89 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain and specifically in striatal medium spiny neurons and cortical and hippocampal pyramidal neurons. Gene-set analyses implicate pathways related to neurogenesis, neuron differentiation and synaptic structure. We confirm previous strong genetic correlations with several neuropsychiatric disorders, and Mendelian Randomization results suggest protective effects of intelligence for Alzheimer’s dementia and ADHD, and bidirectional causation with strong pleiotropy for schizophrenia. These results are a major step forward in understanding the neurobiology of intelligence as well as genetically associated neuropsychiatric traits.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted September 06, 2017.
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
bioRxiv 184853; doi: https://doi.org/10.1101/184853
GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
bioRxiv 184853; doi: https://doi.org/10.1101/184853
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