New Results

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
doi: https://doi.org/10.1101/184853

Article Information

doi 
https://doi.org/10.1101/184853
History 
  • September 6, 2017.

Article Versions

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Jeanne E Savage1,#,
  2. Philip R Jansen1,2,#,
  3. Sven Stringer1,
  4. Kyoko Watanabe1,
  5. Julien Bryois3,
  6. Christiaan A de Leeuw1,
  7. Mats Nagel1,
  8. Swapnil Awasthi4,
  9. Peter B Barr5,
  10. Jonathan R I Coleman6,7,
  11. Katrina L Grasby8,
  12. Anke R Hammerschlag1,
  13. Jakob Kaminski4,9,
  14. Robert Karlsson3,
  15. Eva Krapohl6,
  16. Max Lam10,
  17. Marianne Nygaard11,12,
  18. Chandra A Reynolds13,
  19. Joey W Trampush14,
  20. Hannah Young15,
  21. Delilah Zabaneh6,
  22. Sara Hägg3,
  23. Narelle K Hansell16,
  24. Ida K Karlsson3,
  25. Sten Linnarsson17,
  26. Grant W Montgomery8,18,
  27. Ana B Muñoz-Manchado17,
  28. Erin B Quinlan6,
  29. Gunter Schumann6,
  30. Nathan Skene17,
  31. Bradley T Webb19,20,21,
  32. Tonya White2,
  33. Dan E Arking22,
  34. Deborah K Attix23,24,
  35. Dimitrios Avramopoulos22,25,
  36. Robert M Bilder26,
  37. Panos Bitsios27,
  38. Katherine E Burdick28,29,30,
  39. Tyrone D Cannon31,
  40. Ornit Chiba-Falek32,
  41. Andrea Christoforou23,
  42. Elizabeth T Cirulli33,
  43. Eliza Congdon26,
  44. Aiden Corvin34,
  45. Gail Davies35,36,
  46. Ian J Deary35,36,
  47. Pamela DeRosse37,
  48. Dwight Dickinson38,
  49. Srdjan Djurovic39,40,
  50. Gary Donohoe41,
  51. Emily Drabant Conley42,
  52. Johan G Eriksson43,44,
  53. Thomas Espeseth45,46,
  54. Nelson A Freimer26,
  55. Stella Giakoumaki47,
  56. Ina Giegling48,
  57. Michael Gill34,
  58. David C Glahn49,
  59. Ahmad R Hariri50,
  60. Alex Hatzimanolis51,52,53,
  61. Matthew C Keller54,
  62. Emma Knowles49,
  63. Bettina Konte48,
  64. Jari Lahti55,56,
  65. Stephanie Le Hellard23,40,
  66. Todd Lencz37,57,58,
  67. David C Liewald36,
  68. Edythe London26,
  69. Astri J Lundervold59,
  70. Anil K Malhotra37,57,58,
  71. Ingrid Melle40,46,
  72. Derek Morris41,
  73. Anna C Need60,
  74. William Ollier61,
  75. Aarno Palotie62,63,64,
  76. Antony Payton65,
  77. Neil Pendleton66,
  78. Russell A Poldrack67,
  79. Katri Räikkönen68,
  80. Ivar Reinvang45,
  81. Panos Roussos28,29,69,
  82. Dan Rujescu48,
  83. Fred W Sabb70,
  84. Matthew A Scult50,
  85. Olav B Smeland40,71,
  86. Nikolaos Smyrnis51,52,
  87. John M Starr35,72,
  88. Vidar M Steen23,40,
  89. Nikos C Stefanis51,52,53,
  90. Richard E Straub73,
  91. Kjetil Sundet45,46,
  92. Aristotle N Voineskos74,
  93. Daniel R Weinberger73,
  94. Elisabeth Widen62,
  95. Jin Yu37,
  96. Goncalo Abecasis75,76,
  97. Ole A Andreassen40,46,77,
  98. Gerome Breen6,7,
  99. Lene Christiansen11,12,
  100. Birgit Debrabant12,
  101. Danielle M Dick5,21,78,
  102. Andreas Heinz4,
  103. Jens Hjerling-Leffler17,
  104. M Arfan Ikram79,
  105. Kenneth S Kendler19,20,21,
  106. Nicholas G Martin8,
  107. Sarah E Medland8,
  108. Nancy L Pedersen3,
  109. Robert Plomin6,
  110. Tinca JC Polderman1,
  111. Stephan Ripke4,80,81,
  112. Sophie van der Sluis1,
  113. Patrick F Sullivan3,82,
  114. Henning Tiemeier2,79,
  115. Scott I Vrieze15,
  116. Margaret J Wright16,83 and
  117. Danielle Posthuma1,84,*
  1. 1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, The Netherlands
  2. 2Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
  3. 3Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  4. 4Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
  5. 5Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
  6. 6Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
  7. 7NIHR Biomedical Research Centre for Mental Health, South London and Maudsley NHS Trust, London, UK
  8. 8QIMR Berghofer Medical Research Institute, Herston, Brisbane, Australia
  9. 9Berlin Institute of Health (BIH), 10178 Berlin, Germany
  10. 10Institute of Mental Health, Singapore
  11. 11The Danish Twin Registry and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark
  12. 12Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark
  13. 13Department of Psychology, University of California Riverside, Riverside, CA, USA
  14. 14BrainWorkup, LLC, Los Angeles, CA
  15. 15Department of Psychology, University of Minnesota
  16. 16Queensland Brain Institute, University of Queensland, Brisbane, Australia
  17. 17Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  18. 18Institute for Molecular Biosciences, University of Queensland, Brisbane, Australia
  19. 19Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, USA
  20. 20Department of Psychiatry, Virginia Commonwealth University, Richmond, USA
  21. 21Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, USA
  22. 22McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, MD, Baltimore, USA
  23. 23Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway
  24. 24Psychiatry and Behavioral Sciences, Division of Medical Psychology, and Department of Neurology, Duke University Medical Center, Durham, NC, USA
  25. 25Department of Psychiatry, Johns Hopkins University School of Medicine, MD, Baltimore, USA
  26. 26UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
  27. 27Department of Psychiatry and Behavioral Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
  28. 28Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  29. 29Mental Illness Research, Education, and Clinical Center (VISN 2), James J. Peters VA Medical Center, Bronx, NY, USA
  30. 30Department of Psychiatry - Brigham and Women’s Hospital; Harvard Medical School; Boston MA
  31. 31Department of Psychology, Yale University, New Haven, CT, USA
  32. 32Department of Neurology, Bryan Alzheimer’s Disease Research Center, and Center for Genomic and Computational Biology, Duke University Medical Center, Durham, NC, USA
  33. 33Human Longevity Inc, Durham, NC, USA
  34. 34Neuropsychiatric Genetics Research Group, Department of Psychiatry and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
  35. 35Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
  36. 36Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
  37. 37Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA
  38. 38Clinical and Translational Neuroscience Branch, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
  39. 39Department of Medical Genetics, Oslo University Hospital, University of Bergen, Oslo, Norway.
  40. 40NORMENT, K.G. Jebsen Centre for Psychosis Research, University of Bergen, Bergen, Norway
  41. 41Neuroimaging, Cognition & Genomics (NICOG) Centre, School of Psychology and Discipline of Biochemistry, National University of Ireland, Galway, Ireland
  42. 4223andMe, Inc., Mountain View, CA, USA
  43. 43Department of General Practice and Primary Health Care, University of Helsinki
  44. 44Helsinki University Hospital, Helsinki, Finland
  45. 45Department of Psychology, University of Oslo, Oslo, Norway
  46. 46Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
  47. 47Department of Psychology, University of Crete, Greece
  48. 48Department of Psychiatry, Martin Luther University of Halle-Wittenberg, Halle, Germany
  49. 49Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
  50. 50Laboratory of NeuroGenetics, Department of Psychology & Neuroscience, Duke University, Durham, NC, USA
  51. 51Department of Psychiatry, National and Kapodistrian University of Athens Medical School, Eginition Hospital, Athens, Greece
  52. 52University Mental Health Research Institute, Athens, Greece
  53. 53Neurobiology Research Institute, Theodor-Theohari Cozzika Foundation, Athens, Greece
  54. 54Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado
  55. 55Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
  56. 56Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
  57. 57Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York
  58. 58Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset New York
  59. 59Department of Biological and Medical Psychology, University of Bergen, Norway
  60. 60Division of Brain Sciences, Department of Medicine, Imperial College, London, UK
  61. 61Centre for Integrated Genomic Medical Research, Institute of Population Health, University of Manchester, Manchester, United Kingdom
  62. 62Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Finland
  63. 63Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
  64. 64Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts
  65. 65Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, United Kingdom
  66. 66Division of Neuroscience and Experimental Psychology/ School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom
  67. 67Department of Psychology, Stanford University, Palo Alto, CA, USA
  68. 68Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland
  69. 69Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  70. 70Robert and Beverly Lewis Center for Neuroimaging, University of Oregon, Eugene, OR, USA
  71. 71Department of Neuroscience, University of California San Diego, La Jolla, California, USA
  72. 72Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
  73. 73Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA
  74. 74Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
  75. 75Department of Biostatistics, University of Michigan, Ann Arbor, USA
  76. 76Center for Statistical Genetics, University of Michigan, Ann Arbor, USA
  77. 77Institute of Clinical Medicine, University of Oslo, Oslo, Norway
  78. 78College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, USA
  79. 79Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
  80. 80Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, USA
  81. 81Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, USA
  82. 82Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
  83. 83Centre for Advanced Imaging, University of Queensland, Brisbane, Australia
  84. 84Department of Clinical Genetics, section Complex Trait Genetics, Neuroscience Campus Amsterdam, VU Medical Center, Amsterdam, the Netherlands
  1. ↵*Correspondence to: Danielle Posthuma: Department of Complex Trait Genetics, VU University, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands. Phone: +31 20 598 2823, Fax: +31 20 5986926, d.posthuma{at}vu.nl

  1. ↵# These authors contributed equally

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Posted September 06, 2017.
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GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence
Jeanne E Savage, Philip R Jansen, Sven Stringer, Kyoko Watanabe, Julien Bryois, Christiaan A de Leeuw, Mats Nagel, Swapnil Awasthi, Peter B Barr, Jonathan R I Coleman, Katrina L Grasby, Anke R Hammerschlag, Jakob Kaminski, Robert Karlsson, Eva Krapohl, Max Lam, Marianne Nygaard, Chandra A Reynolds, Joey W Trampush, Hannah Young, Delilah Zabaneh, Sara Hägg, Narelle K Hansell, Ida K Karlsson, Sten Linnarsson, Grant W Montgomery, Ana B Muñoz-Manchado, Erin B Quinlan, Gunter Schumann, Nathan Skene, Bradley T Webb, Tonya White, Dan E Arking, Deborah K Attix, Dimitrios Avramopoulos, Robert M Bilder, Panos Bitsios, Katherine E Burdick, Tyrone D Cannon, Ornit Chiba-Falek, Andrea Christoforou, Elizabeth T Cirulli, Eliza Congdon, Aiden Corvin, Gail Davies, Ian J Deary, Pamela DeRosse, Dwight Dickinson, Srdjan Djurovic, Gary Donohoe, Emily Drabant Conley, Johan G Eriksson, Thomas Espeseth, Nelson A Freimer, Stella Giakoumaki, Ina Giegling, Michael Gill, David C Glahn, Ahmad R Hariri, Alex Hatzimanolis, Matthew C Keller, Emma Knowles, Bettina Konte, Jari Lahti, Stephanie Le Hellard, Todd Lencz, David C Liewald, Edythe London, Astri J Lundervold, Anil K Malhotra, Ingrid Melle, Derek Morris, Anna C Need, William Ollier, Aarno Palotie, Antony Payton, Neil Pendleton, Russell A Poldrack, Katri Räikkönen, Ivar Reinvang, Panos Roussos, Dan Rujescu, Fred W Sabb, Matthew A Scult, Olav B Smeland, Nikolaos Smyrnis, John M Starr, Vidar M Steen, Nikos C Stefanis, Richard E Straub, Kjetil Sundet, Aristotle N Voineskos, Daniel R Weinberger, Elisabeth Widen, Jin Yu, Goncalo Abecasis, Ole A Andreassen, Gerome Breen, Lene Christiansen, Birgit Debrabant, Danielle M Dick, Andreas Heinz, Jens Hjerling-Leffler, M Arfan Ikram, Kenneth S Kendler, Nicholas G Martin, Sarah E Medland, Nancy L Pedersen, Robert Plomin, Tinca JC Polderman, Stephan Ripke, Sophie van der Sluis, Patrick F Sullivan, Henning Tiemeier, Scott I Vrieze, Margaret J Wright, Danielle Posthuma
bioRxiv 184853; doi: https://doi.org/10.1101/184853
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