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Antibiotic collateral sensitivity is contingent on the repeatability of evolution
View ORCID ProfileDaniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M Hujer, Sai Lek, Mark D Adams, Peter Jeavons, View ORCID ProfileAlexander RA Anderson, Robert A Bonomo, View ORCID ProfileJacob G Scott
doi: https://doi.org/10.1101/185892
Daniel Nichol
1Department of Computer Science, University of Oxford, Oxford, UK
2Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
†Evolutionary Genomics & Modelling Lab, Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK
Joseph Rutter
3Research Service, Louis Stokes Department of Veterans Affairs Hospital, Cleveland, OH, USA
Christopher Bryant
4Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Andrea M Hujer
3Research Service, Louis Stokes Department of Veterans Affairs Hospital, Cleveland, OH, USA
4Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Sai Lek
5The Jackson Laboratory for Genomic Medicine, 10 Discovery Dr, Farmington, CT, USA
Mark D Adams
5The Jackson Laboratory for Genomic Medicine, 10 Discovery Dr, Farmington, CT, USA
Peter Jeavons
1Department of Computer Science, University of Oxford, Oxford, UK
Alexander RA Anderson
2Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Robert A Bonomo
3Research Service, Louis Stokes Department of Veterans Affairs Hospital, Cleveland, OH, USA
4Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
6Departments of Biochemistry, Molecular Biology and Microbiology, and Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH, USA
7Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
8Medicine Service and Geriatric Research Education and Clinical Center (GRECC), Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, USA
9CARES, CWRU-VA Center for Antibiotic Resistance and Epidemiology, Cleveland, OH, USA
Jacob G Scott
7Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
10Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, UK
11Departments of Translational Hematology and Oncology Research and Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA
Posted January 09, 2019.
Antibiotic collateral sensitivity is contingent on the repeatability of evolution
Daniel Nichol, Joseph Rutter, Christopher Bryant, Andrea M Hujer, Sai Lek, Mark D Adams, Peter Jeavons, Alexander RA Anderson, Robert A Bonomo, Jacob G Scott
bioRxiv 185892; doi: https://doi.org/10.1101/185892
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