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Instantiation of incentive value and movement invigoration by distinct midbrain dopamine circuits

View ORCID ProfileBenjamin T. Saunders, View ORCID ProfileJocelyn M. Richard, Elyssa B. Margolis, View ORCID ProfilePatricia H. Janak
doi: https://doi.org/10.1101/186502
Benjamin T. Saunders
1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
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Jocelyn M. Richard
1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
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Elyssa B. Margolis
2Department of Neurology, Wheeler Center for the Neurobiology of Addiction, Alcoholism and Addiction Research Group, University of California San Francisco, CA 94158, USA
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Patricia H. Janak
1Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
3Department of Neuroscience, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD 21218, USA
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Abstract

Environmental cues, through Pavlovian learning, become conditioned stimuli that guide animals towards the acquisition of “rewards” (i.e., food) that are necessary for survival. Here, we test the fundamental role of midbrain dopamine neurons in conferring predictive or motivational properties to cues, independent of external rewards. We demonstrate that phasic optogenetic excitation of dopamine neurons throughout the midbrain, when presented in temporal association with discrete sensory cues, is sufficient to instantiate those cues as conditioned stimuli that subsequently both evoke dopamine neuron activity on their own, and elicit cue-locked conditioned behaviors. Critically, we identify highly parcellated behavioral functions for dopamine neuron subpopulations projecting to discrete regions of striatum, revealing dissociable mesostriatal systems for the generation of incentive value and movement invigoration. These results show that dopamine neurons orchestrate Pavlovian conditioning via functionally heterogeneous, circuit-specific motivational signals to shape cue-controlled behavior.

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Posted October 07, 2017.
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Instantiation of incentive value and movement invigoration by distinct midbrain dopamine circuits
Benjamin T. Saunders, Jocelyn M. Richard, Elyssa B. Margolis, Patricia H. Janak
bioRxiv 186502; doi: https://doi.org/10.1101/186502
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Instantiation of incentive value and movement invigoration by distinct midbrain dopamine circuits
Benjamin T. Saunders, Jocelyn M. Richard, Elyssa B. Margolis, Patricia H. Janak
bioRxiv 186502; doi: https://doi.org/10.1101/186502

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