Abstract
Aim/Hypotheses The minor allele of CREBRF rs373863828 associates with increased body mass index (BMI) and reduced risk of type 2 diabetes (T2D) in the Samoan population of Samoa and American Samoa. Our aim was to test rs373863828 for association with BMI and odds of T2D, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa New Zealand in 2,286 adults.
Methods Association analyses were performed by linear and logistic regression with BMI, log-transformed BMI, waist circumference, T2D, gout and CKD. Analyses were adjusted for age, sex, the first four genome-wide principal components, and (when appropriate) BMI, waist circumference and T2D.
Results For the minor allele of rs373863828 the effect size for log-transformed BMI was 0.038 (95% CI [0.022-0.055], P=4.8x10−6) and for T2D was OR=0.59 (95% CI [0.47-0.73], P=1.9x10−6). There was no evidence for association of genotype with variance in BMI (P=0.13). Nor was there evidence for association with serum urate (β=0.012 mmol/L, Pc=0.10), gout (OR=1.00, P=0.98) or CKD (OR=0.91, P=0.59).
Conclusions/interpretation Our results replicated, with very similar effect sizes, association of the minor allele of rs373863828 with higher BMI but lower odds of T2D among New Zealand Polynesian adults, as in Samoan adults living in Samoa and American Samoa.
Footnotes
Abbreviations: AIC, Akaike Information Criteria; CKD, chronic kidney disease; CREBRF, cAMP-responsive element binding protein 3 regulatory factor; FTO, fat mass and obesity-associated; IRX3, iriquois-class homeodomain 3; MAF, minor allele frequency
