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Single synapses control mossy cell firing

Alexander Drakew, View ORCID ProfileUrban Maier, Anja Tippmann, Michael Frotscher
doi: https://doi.org/10.1101/188789
Alexander Drakew
1Institute for Structural Neurobiology, Centre for Molecular Neurobiology Hamburg (ZMNH), University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany
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  • For correspondence: alexander.drakew@zmnh.uni-hamburg.de
Urban Maier
1Institute for Structural Neurobiology, Centre for Molecular Neurobiology Hamburg (ZMNH), University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany
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  • ORCID record for Urban Maier
Anja Tippmann
1Institute for Structural Neurobiology, Centre for Molecular Neurobiology Hamburg (ZMNH), University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany
2current address: Systems Neuroscience, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, Georg August University Göttingen, 37075 Göttingen, Germany
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Michael Frotscher
1Institute for Structural Neurobiology, Centre for Molecular Neurobiology Hamburg (ZMNH), University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany
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Abstract

The function of mossy cells (MCs) in the dentate gyrus has remained elusive. Here we determined the functional impact of single mossy fibre (MF) synapses on MC firing in mouse entorhino-hippocampal slice cultures. We stimulated single MF boutons and recorded Ca2+ transients in the postsynaptic spine and unitary excitatory postsynaptic potentials (EPSPs) at the MC soma. Synaptic responses to single presynaptic stimuli varied strongly between different MF synapses, even if they were located on the same MC dendrite. Synaptic strengths ranged from subthreshold EPSPs to direct postsynaptic action potential (AP) generation. Induction of synaptic plasticity at these individual MF synapses resulted in potentiation or depression depending on the initially encountered synaptic state, indicating that synaptic transmission at MF synapses on MCs is determined by their previous functional history. With these unique functional properties MF-MC synapses control MC firing individually thereby enabling modulation of the dentate network by single granule cells.

Footnotes

  • ↵† Michael Frotscher passed away on May, 27 2017

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 29, 2017.
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Single synapses control mossy cell firing
Alexander Drakew, Urban Maier, Anja Tippmann, Michael Frotscher
bioRxiv 188789; doi: https://doi.org/10.1101/188789
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Single synapses control mossy cell firing
Alexander Drakew, Urban Maier, Anja Tippmann, Michael Frotscher
bioRxiv 188789; doi: https://doi.org/10.1101/188789

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