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Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Meena Subramaniam, Rachel E. Gate, Tushar Bhangale, Mark N. Lee, Towfique Raj, Raktima Raychowdhury, Weibo Li, Noga Rogel, Selina H. Imboywa, Portia I. Chipendo, Cristin McCabe, Michelle H. Lee, Irene Y. Frohlich, Barbara E. Stranger, Philip L. De Jager, Aviv Regev, Tim Behrens, Nir Hacohen
doi: https://doi.org/10.1101/188961
Chun Jimmie Ye
1Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA
Jenny Chen
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
3Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139
Alexandra-Chloé Villani
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
4Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02139
Meena Subramaniam
1Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA
5Biomedical Informatics Program, University of California, San Francisco
Rachel E. Gate
1Institute for Human Genetics, Institute for Health and Computational Sciences, Department of Biostatistics and Epidemiology, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA
5Biomedical Informatics Program, University of California, San Francisco
Tushar Bhangale
6Genentech Inc., South San Francisco, CA
Mark N. Lee
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
4Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02139
7Harvard Medical School, Boston, MA 02116
Towfique Raj
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
7Harvard Medical School, Boston, MA 02116
8Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA.
13Present address: Ronald M. Loeb Center for Alzheimer’s Disease, Departments of Genetics and Genomic Sciences, and Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Raktima Raychowdhury
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
Weibo Li
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
Noga Rogel
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
Selina H. Imboywa
7Harvard Medical School, Boston, MA 02116
Portia I. Chipendo
7Harvard Medical School, Boston, MA 02116
Cristin McCabe
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
8Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA.
Michelle H. Lee
7Harvard Medical School, Boston, MA 02116
Irene Y. Frohlich
7Harvard Medical School, Boston, MA 02116
Barbara E. Stranger
9Section of Genetic Medicine, Department of Medicine, Institute for Genomics and Systems Biology, Center for Data Intensive Science, The University of Chicago, Chicago, IL 60637
Philip L. De Jager
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
7Harvard Medical School, Boston, MA 02116
8Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA.
14Present address: Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY 10032.
Aviv Regev
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
10Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139
11Howard Hughes Medical Institute, Chevy Chase, MD 20815
Tim Behrens
6Genentech Inc., South San Francisco, CA
Nir Hacohen
2Broad Institute of MIT and Harvard, 415 Main Street, Cambridge MA 02142, USA
4Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02139
Article usage
Posted October 31, 2017.
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Meena Subramaniam, Rachel E. Gate, Tushar Bhangale, Mark N. Lee, Towfique Raj, Raktima Raychowdhury, Weibo Li, Noga Rogel, Selina H. Imboywa, Portia I. Chipendo, Cristin McCabe, Michelle H. Lee, Irene Y. Frohlich, Barbara E. Stranger, Philip L. De Jager, Aviv Regev, Tim Behrens, Nir Hacohen
bioRxiv 188961; doi: https://doi.org/10.1101/188961
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection
Chun Jimmie Ye, Jenny Chen, Alexandra-Chloé Villani, Meena Subramaniam, Rachel E. Gate, Tushar Bhangale, Mark N. Lee, Towfique Raj, Raktima Raychowdhury, Weibo Li, Noga Rogel, Selina H. Imboywa, Portia I. Chipendo, Cristin McCabe, Michelle H. Lee, Irene Y. Frohlich, Barbara E. Stranger, Philip L. De Jager, Aviv Regev, Tim Behrens, Nir Hacohen
bioRxiv 188961; doi: https://doi.org/10.1101/188961
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