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In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

View ORCID ProfileArnoud Boot, Mi Ni Huang, Alvin W.T. Ng, Szu-Chi Ho, Jing Quan Lim, Yoshiiku Kawakami, Kazuaki Chayama, Bin Tean Teh, Hidewaki Nakagawa, Steven G. Rozen
doi: https://doi.org/10.1101/189233
Arnoud Boot
1Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
2Centre for Computational Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
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  • ORCID record for Arnoud Boot
Mi Ni Huang
1Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
2Centre for Computational Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
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Alvin W.T. Ng
2Centre for Computational Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
3NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, 117456, Singapore
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Szu-Chi Ho
1Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
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Jing Quan Lim
4Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Centre Singapore, 169610, Singapore
5Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, 169610, Singapore
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Yoshiiku Kawakami
6Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
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Kazuaki Chayama
6Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
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Bin Tean Teh
7Division of Medical Sciences, National Cancer Centre Singapore.
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Hidewaki Nakagawa
8Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
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Steven G. Rozen
1Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
2Centre for Computational Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
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  • For correspondence: steve.rozen@duke-nus.edu.sg
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Article Information

doi 
https://doi.org/10.1101/189233
History 
  • December 17, 2017.

Article Versions

  • Version 1 (September 17, 2017 - 07:58).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Arnoud Boot1,2,
  2. Mi Ni Huang1,2,
  3. Alvin W.T. Ng2,3,
  4. Szu-Chi Ho1,
  5. Jing Quan Lim4,5,
  6. Yoshiiku Kawakami6,
  7. Kazuaki Chayama6,
  8. Bin Tean Teh7,
  9. Hidewaki Nakagawa8 and
  10. Steven G. Rozen1,2,*
  1. 1Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
  2. 2Centre for Computational Biology, Duke-NUS Medical School, 8 College Road, 169857, Singapore
  3. 3NUS Graduate School for Integrative Sciences and Engineering, 28 Medical Drive, 117456, Singapore
  4. 4Laboratory of Cancer Epigenome, Division of Medical Science, National Cancer Centre Singapore, 169610, Singapore
  5. 5Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, 169610, Singapore
  6. 6Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
  7. 7Division of Medical Sciences, National Cancer Centre Singapore.
  8. 8Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
  1. ↵*Corresponding author: Steven G. Rozen, steve.rozen{at}duke-nus.edu.sg
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Posted December 17, 2017.
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In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
Arnoud Boot, Mi Ni Huang, Alvin W.T. Ng, Szu-Chi Ho, Jing Quan Lim, Yoshiiku Kawakami, Kazuaki Chayama, Bin Tean Teh, Hidewaki Nakagawa, Steven G. Rozen
bioRxiv 189233; doi: https://doi.org/10.1101/189233
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In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors
Arnoud Boot, Mi Ni Huang, Alvin W.T. Ng, Szu-Chi Ho, Jing Quan Lim, Yoshiiku Kawakami, Kazuaki Chayama, Bin Tean Teh, Hidewaki Nakagawa, Steven G. Rozen
bioRxiv 189233; doi: https://doi.org/10.1101/189233

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