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Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness

Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Samuel JE Lucas, Damian M. Bailey, Jonathan D. Smirl, View ORCID ProfilePatrice Brassard
doi: https://doi.org/10.1101/190405
Lawrence Labrecque
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Kevan Rahimaly
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Sarah Imhoff
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Myriam Paquette
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Olivier Le Blanc
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Simon Malenfant
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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Samuel JE Lucas
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK Department of Physiology, University of Otago, Dunedin, New Zealand
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Damian M. Bailey
Neurovascular Research. Laboratory, Faculty of Life Sciences and Education, University of South Wales, South Wales, UK Faculty of Medicine, Reichwald Health Sciences Centre, University of British Columbia–Okanagan, Kelowna, BC, Canada
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Jonathan D. Smirl
Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna BC, Canada
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Patrice Brassard
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada Research center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
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  • ORCID record for Patrice Brassard
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Abstract

The effect that cardiorespiratory fitness has on the dynamic cerebral autoregulatory capacity during changes in mean arterial pressure (MAP) remains equivocal. Using a multiple-metrics approach, challenging MAP across the spectrum of physiological extremes (i.e. spontaneous through forced MAP oscillations), we characterized dynamic cerebral autoregulatory capacity in 19 male endurance athletes and 8 controls via three methods: [1] onset of regulation (i.e., time delay before an increase in middle cerebral artery (MCA) conductance [MCA flow velocity (MCAv)/mean arterial pressure (MAP)] and rate of regulation, after transient hypotension induced by sit-to-stand, and transfer function analysis (TFA) of MAP and MCAv responses during [2] spontaneous and [3] forced oscillations (5-min of squat-stand maneuvers performed at 0.05 and 0.10 Hz). Reductions in MAP and mean MCAv (MCAVmean) during initial orthostatic stress (0-30 s after sit-to-stand) and the prevalence of orthostatic hypotension were also determined. Onset of regulation was delayed after sit-to-stand in athletes (3.1±1.7 vs. 1.5±1.0 s; p=0.03), but rate of regulation was not different between groups (0.24±0.05 vs. 0.21±0.09 s-1; p=0.82). While both groups had comparable TFA metrics during spontaneous oscillations, athletes had higher TFA gain during 0.10 Hz squat-stand vs. recreational controls (p=0.01). Reductions in MAP (p=0.15) and MCAVmean (p=0.11) during orthostatic stress and the prevalence of initial orthostatic hypotension (p=0.65) were comparable between groups. These results indicate an intact ability of the cerebral vasculature to react to spontaneous oscillations but an attenuated capability to counter rapid and large changes in MAP in individuals with elevated cardiorespiratory fitness.

What is the central question of this study?

  • What is the impact of cardiorespiratory fitness on dynamic cerebral autoregulatory capacity?

What is the main finding and its importance?

  • Our results indicate an intact ability of the cerebral vasculature to react to spontaneous oscillations but an attenuated capability to counter rapid and large changes in mean arterial pressure in individuals with elevated cardiorespiratory fitness.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted September 28, 2017.
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Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness
Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Samuel JE Lucas, Damian M. Bailey, Jonathan D. Smirl, Patrice Brassard
bioRxiv 190405; doi: https://doi.org/10.1101/190405
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Diminished dynamic cerebral autoregulatory capacity with forced oscillations in mean arterial pressure with elevated cardiorespiratory fitness
Lawrence Labrecque, Kevan Rahimaly, Sarah Imhoff, Myriam Paquette, Olivier Le Blanc, Simon Malenfant, Samuel JE Lucas, Damian M. Bailey, Jonathan D. Smirl, Patrice Brassard
bioRxiv 190405; doi: https://doi.org/10.1101/190405

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