Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion

Alexandra Surcel; Eric Schiffhauer; Dustin Thomas; Qingfeng Zhu; Kathleen DiNapoli; Maik Herbig; Oliver Otto; Jochen Guck; Elizabeth Jaffee; Pablo Iglesias; Robert Anders; Douglas Robinson

doi:10.1101/190553

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Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion

Alexandra Surcel, Eric Schiffhauer, Dustin Thomas, Qingfeng Zhu, Kathleen DiNapoli, Maik Herbig, Oliver Otto, Jochen Guck, Elizabeth Jaffee, Pablo Iglesias, Robert Anders, Douglas Robinson

doi: https://doi.org/10.1101/190553

Alexandra Surcel

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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For correspondence: asurcel1@jhmi.edu dnr@jhmi.edu

Eric Schiffhauer

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Dustin Thomas

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Qingfeng Zhu

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Kathleen DiNapoli

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

3Department of Electrical and Computer Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA

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Maik Herbig

4Biotechnology Center, TU Dresden, 01307 Dresden, Germany

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Oliver Otto

4Biotechnology Center, TU Dresden, 01307 Dresden, Germany

5Current address: Centre for Innovation Competence, Humoral Immune Reactions in Cardiovascular Diseases Biomechanics, University of Greifswald, 17489 Greifswald, Germany

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Jochen Guck

4Biotechnology Center, TU Dresden, 01307 Dresden, Germany

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Elizabeth Jaffee

6Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Pablo Iglesias

3Department of Electrical and Computer Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA

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Robert Anders

2Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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Douglas Robinson

1Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

7Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

8Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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For correspondence: asurcel1@jhmi.edu dnr@jhmi.edu

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Posted September 19, 2017.

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Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion

Alexandra Surcel, Eric Schiffhauer, Dustin Thomas, Qingfeng Zhu, Kathleen DiNapoli, Maik Herbig, Oliver Otto, Jochen Guck, Elizabeth Jaffee, Pablo Iglesias, Robert Anders, Douglas Robinson

bioRxiv 190553; doi: https://doi.org/10.1101/190553

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Harnessing the adaptive potential of mechanoresponsive proteins to overwhelm pancreatic cancer dissemination and invasion

Alexandra Surcel, Eric Schiffhauer, Dustin Thomas, Qingfeng Zhu, Kathleen DiNapoli, Maik Herbig, Oliver Otto, Jochen Guck, Elizabeth Jaffee, Pablo Iglesias, Robert Anders, Douglas Robinson

bioRxiv 190553; doi: https://doi.org/10.1101/190553

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