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Catecholaminergic modulation of the avoidance of cognitive control

Monja I. Froböse, Jennifer C. Swart, Jennifer L. Cook, Dirk E.M. Geurts, Hanneke E.M. den Ouden, Roshan Cools
doi: https://doi.org/10.1101/191015
Monja I. Froböse
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
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Jennifer C. Swart
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
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Jennifer L. Cook
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
2School of Psychology, University of Birmingham, Edgbaston, Birmingham, United Kingdom
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Dirk E.M. Geurts
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
3Dept psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands.
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Hanneke E.M. den Ouden
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
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Roshan Cools
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
3Dept psychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands.
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Abstract

The catecholamines have long been associated with cognitive control and value-based decision-making. More recently, we proposed that the catecholamines might modulate value-based decision-making about whether or not to engage in cognitive control. We test this hypothesis by assessing effects of a catecholamine challenge in a large sample of young, healthy adults (n = 100) on the avoidance of a cognitively demanding control process: task switching. Prolonging catecholamine transmission by blocking reuptake with methylphenidate altered the avoidance, but not the execution of cognitive control. Crucially, these effects could be isolated by taking into account individual differences in trait impulsivity, so that participants with higher trait impulsivity became more avoidant of cognitive control, despite faster task performance. One implication of these findings is that performance-enhancing effects of methylphenidate may be accompanied by an undermining effect on the willingness to exert cognitive control. Taken together, these findings integrate hitherto segregated literatures on catecholamines’ roles in value-based learning/choice and cognitive control.

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Posted September 20, 2017.
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Catecholaminergic modulation of the avoidance of cognitive control
Monja I. Froböse, Jennifer C. Swart, Jennifer L. Cook, Dirk E.M. Geurts, Hanneke E.M. den Ouden, Roshan Cools
bioRxiv 191015; doi: https://doi.org/10.1101/191015
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Catecholaminergic modulation of the avoidance of cognitive control
Monja I. Froböse, Jennifer C. Swart, Jennifer L. Cook, Dirk E.M. Geurts, Hanneke E.M. den Ouden, Roshan Cools
bioRxiv 191015; doi: https://doi.org/10.1101/191015

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