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Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma

Bárbara Kunzler Souza, Patrícia Luciana da Costa Lopez, Pâmela Rossi Menegotto, Igor Araujo Vieira, Nathalia Kersting, Ana Lúcia Abujamra, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Carol J. Thiele, Rafael Roesler
doi: https://doi.org/10.1101/191700
Bárbara Kunzler Souza
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil
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Patrícia Luciana da Costa Lopez
3Graduate Program in Gastroenterology and Hepatology, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
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Pâmela Rossi Menegotto
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil
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Igor Araujo Vieira
4Laboratory of Genomic Medicine, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
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Nathalia Kersting
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
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Ana Lúcia Abujamra
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil
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André T. Brunetto
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil
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Algemir L. Brunetto
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil
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Lauro Gregianin
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
6Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
7Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
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Caroline Brunetto de Farias
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil
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Carol J. Thiele
8Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA
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Rafael Roesler
1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil
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Article Information

doi 
https://doi.org/10.1101/191700
History 
  • January 16, 2018.

Article Versions

  • Version 1 (September 20, 2017 - 19:04).
  • Version 2 (January 6, 2018 - 17:14).
  • You are viewing Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Bárbara Kunzler Souza1,2,
  2. Patrícia Luciana da Costa Lopez3,
  3. Pâmela Rossi Menegotto1,2,
  4. Igor Araujo Vieira4,
  5. Nathalia Kersting1,
  6. Ana Lúcia Abujamra1,5,
  7. André T. Brunetto1,5,
  8. Algemir L. Brunetto1,5,
  9. Lauro Gregianin1,6,7,
  10. Caroline Brunetto de Farias1,5,
  11. Carol J. Thiele8 and
  12. Rafael Roesler1,2
  1. 1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
  2. 2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil
  3. 3Graduate Program in Gastroenterology and Hepatology, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
  4. 4Laboratory of Genomic Medicine, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
  5. 5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil
  6. 6Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
  7. 7Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil
  8. 8Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA
  1. Correspondence: Rafael Roesler, Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Rua Sarmento Leite, 500 (ICBS, Campus Centro/UFRGS), 90050-170 Porto Alegre, RS, Brazil. Telephone: +5551 33083183; fax: +5551 33083121. E-mail: rafaelroesler{at}hcpa.edu.br
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Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma
Bárbara Kunzler Souza, Patrícia Luciana da Costa Lopez, Pâmela Rossi Menegotto, Igor Araujo Vieira, Nathalia Kersting, Ana Lúcia Abujamra, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Carol J. Thiele, Rafael Roesler
bioRxiv 191700; doi: https://doi.org/10.1101/191700
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Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma
Bárbara Kunzler Souza, Patrícia Luciana da Costa Lopez, Pâmela Rossi Menegotto, Igor Araujo Vieira, Nathalia Kersting, Ana Lúcia Abujamra, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Carol J. Thiele, Rafael Roesler
bioRxiv 191700; doi: https://doi.org/10.1101/191700

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