Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma

Bárbara Kunzler Souza; Patrícia Luciana da Costa Lopez; Pâmela Rossi Menegotto; Igor Araujo Vieira; Nathalia Kersting; Ana Lúcia Abujamra; André T. Brunetto; Algemir L. Brunetto; Lauro Gregianin; Caroline Brunetto de Farias; Carol J. Thiele; Rafael Roesler

doi:10.1101/191700

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Targeting histone deacetylase activity to arrest cell growth and promote neural differentiation in Ewing sarcoma

Bárbara Kunzler Souza, Patrícia Luciana da Costa Lopez, Pâmela Rossi Menegotto, Igor Araujo Vieira, Nathalia Kersting, Ana Lúcia Abujamra, André T. Brunetto, Algemir L. Brunetto, Lauro Gregianin, Caroline Brunetto de Farias, Carol J. Thiele, Rafael Roesler

doi: https://doi.org/10.1101/191700

Bárbara Kunzler Souza

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil

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Patrícia Luciana da Costa Lopez

3Graduate Program in Gastroenterology and Hepatology, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

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Pâmela Rossi Menegotto

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil

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Igor Araujo Vieira

4Laboratory of Genomic Medicine, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

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Nathalia Kersting

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

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Ana Lúcia Abujamra

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil

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André T. Brunetto

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil

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Algemir L. Brunetto

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil

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Lauro Gregianin

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

6Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

7Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

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Caroline Brunetto de Farias

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

5Rafael Koff Acordi Research Center, Children’s Cancer Institute, 90620-110 Porto Alegre, RS, Brazil

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Carol J. Thiele

8Cell & Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, 20892, MD, USA

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Rafael Roesler

1Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, 90035-003 Porto Alegre, RS, Brazil

2Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil