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Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality

View ORCID ProfileArne Sahm, Martin Bens, Karol Szafranski, Susanne Holtze, Marco Groth, Matthias Görlach, Cornelis Calkhoven, Christine Müller, Matthias Schwab, Hans A. Kestler, Alessandro Cellerino, Hynek Burda, Thomas Hildebrandt, Philip Dammann, Matthias Platzer
doi: https://doi.org/10.1101/191999
Arne Sahm
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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  • For correspondence: arne.sahm@leibniz-fli.de
Martin Bens
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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Karol Szafranski
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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Susanne Holtze
2Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
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Marco Groth
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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Matthias Görlach
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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Cornelis Calkhoven
3European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen Groningen, The Netherlands
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Christine Müller
3European Research Institute for the Biology of Ageing, University of Groningen, University Medical Centre Groningen Groningen, The Netherlands
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Matthias Schwab
4Department of Neurology; Jena University Hospital-Friedrich Schiller University, Jena, Germany
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Hans A. Kestler
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
5Institute of Medical Systems Biology, Ulm University, Ulm, Germany
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Alessandro Cellerino
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
6Laboratory of Biology Bio@SNS, Scuola Normale Superiore, Pisa, Italy
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Hynek Burda
7Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany
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Thomas Hildebrandt
2Department of Reproduction Management, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany
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Philip Dammann
7Department of General Zoology, Faculty of Biology, University of Duisburg-Essen, Essen, Germany
8University Hospital, University of Duisburg-Essen, Essen, Germany
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Matthias Platzer
1Leibniz Institute on Aging – Fritz Lipmann Institute, Jena, Germany
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Abstract

The genetic mechanisms that determine lifespan are poorly understood. Most research has been done on short lived animals and it is unclear if these insights can be transferred to long-lived mammals like humans. Some African mole-rats (Bathyergidae) have life expectancies that are multiple times higher than similar sized and phylogenetically closely related rodents. We obtained genomic and transcriptomic data from 17 rodent species and systematically scanned eleven lineages associated with the evolution of longevity and eusociality for positively selected genes (PSGs). The set of 319 PSGs contains regulators of mTOR and is enriched in functional terms associated with (i) processes that are regulated by the mTOR pathway, e.g. translation, autophagy and mitochondrial biogenesis, (ii) the immune system and (iii) antioxidant defense. Analyzing gene expression of PSGs during aging in the long-lived naked mole-rat and up-regulation in the short-lived rat, we found a pattern fitting the antagonistic pleiotropy theory of aging.

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Posted October 08, 2017.
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Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality
Arne Sahm, Martin Bens, Karol Szafranski, Susanne Holtze, Marco Groth, Matthias Görlach, Cornelis Calkhoven, Christine Müller, Matthias Schwab, Hans A. Kestler, Alessandro Cellerino, Hynek Burda, Thomas Hildebrandt, Philip Dammann, Matthias Platzer
bioRxiv 191999; doi: https://doi.org/10.1101/191999
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Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality
Arne Sahm, Martin Bens, Karol Szafranski, Susanne Holtze, Marco Groth, Matthias Görlach, Cornelis Calkhoven, Christine Müller, Matthias Schwab, Hans A. Kestler, Alessandro Cellerino, Hynek Burda, Thomas Hildebrandt, Philip Dammann, Matthias Platzer
bioRxiv 191999; doi: https://doi.org/10.1101/191999

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