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Dysconnection of right parietal and frontal cortex in neglect syndrome

View ORCID ProfileMartin J. Dietz, Jørgen F. Nielsen, Andreas Roepstorff, View ORCID ProfileMarta I. Garrido
doi: https://doi.org/10.1101/192583
Martin J. Dietz
1Center for Functionally Integrative Neuroscience, Institute of Clinical Medicine, Aarhus University, Denmark
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  • For correspondence: martin@cfin.au.dk
Jørgen F. Nielsen
2Hammel Neurorehabilitation and Research Center, Institute of Clinical Medicine, Aarhus University, Denmark
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Andreas Roepstorff
1Center for Functionally Integrative Neuroscience, Institute of Clinical Medicine, Aarhus University, Denmark
3Centre for Interacting Minds, School of Culture and Society, Aarhus University, Denmark
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Marta I. Garrido
4Queensland Brain Institute, The University of Queensland, Australia
5School of Mathematics and Physics, The University of Queensland, Australia
6Centre for Advanced Imaging, The University of Queensland, Australia
7Australian Research Council Centre of Excellence for Integrative Brain Function, The University of Queensland, Australia
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ABSTRACT

A lesion to the right hemisphere of the brain often leads to perceptual neglect of the left side of the sensorium. The fact that lesions to different cortical regions lead to the same symptoms points to neglect as a dysconnection syndrome that may result from the dysconnection of a distributed network, rather than a disruption of computation in any particular brain region. To test this hypothesis, we used Bayesian analysis of effective connectivity based on electroencephalographic recordings in patients with left-sided neglect after a right-hemisphere lesion. While age-matched healthy controls showed a contralateral increase in connection strength between parietal and frontal cortex with respect to the laterality of the stimuli, neglect patients showed a dysconnection between parietal and frontal cortex in the right hemisphere when stimuli appeared on their neglected side, but preserved connectivity in the left hemisphere when stimuli appeared on their right. Crucially, this parieto-frontal feedback connectivity was aggravated in patients with more severe symptoms. In contrast, patients and controls did not show differences in the local connectivity within regions. These findings suggest that the aetiology of neglect may lie in the dysconnection of a distributed network, rather than the disruption of any particular brain region.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 22, 2017.
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Dysconnection of right parietal and frontal cortex in neglect syndrome
Martin J. Dietz, Jørgen F. Nielsen, Andreas Roepstorff, Marta I. Garrido
bioRxiv 192583; doi: https://doi.org/10.1101/192583
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Dysconnection of right parietal and frontal cortex in neglect syndrome
Martin J. Dietz, Jørgen F. Nielsen, Andreas Roepstorff, Marta I. Garrido
bioRxiv 192583; doi: https://doi.org/10.1101/192583

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