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THE HOXD CLUSTER IS A DYNAMIC AND RESILIENT TAD BOUNDARY CONTROLLING THE SEGREGATION OF ANTAGONISTIC REGULATORY LANDSCAPES

Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J. Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hahn Nguyen Huynh, Hakan Ozadam, Job Dekker, View ORCID ProfileDenis Duboule
doi: https://doi.org/10.1101/193706
Eddie Rodríguez-Carballo
1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
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Lucille Lopez-Delisle
2School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
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Ye Zhan
3Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, USA
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Pierre J. Fabre
2School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
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Leonardo Beccari
1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
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Imane El-Idrissi
1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
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Thi Hahn Nguyen Huynh
1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
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Hakan Ozadam
3Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, USA
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Job Dekker
3Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, USA
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Denis Duboule
1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
2School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
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  • ORCID record for Denis Duboule
  • For correspondence: Denis.Duboule@unige.ch Denis.Duboule@epfl.ch
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Article Information

doi 
https://doi.org/10.1101/193706
History 
  • November 24, 2017.

Article Versions

  • Version 1 (September 28, 2017 - 11:42).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Eddie Rodríguez-Carballo1,
  2. Lucille Lopez-Delisle2,
  3. Ye Zhan3,
  4. Pierre J. Fabre2,#,
  5. Leonardo Beccari1,
  6. Imane El-Idrissi1,
  7. Thi Hahn Nguyen Huynh1,
  8. Hakan Ozadam3,
  9. Job Dekker3 and
  10. Denis Duboule1,2,4
  1. 1Department of Genetics and Evolution, University of Geneva, 1205 Geneva, Switzerland
  2. 2School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland
  3. 3Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, USA
  1. ↵4Corresponding author: Denis Duboule, Tel: +41 22 379 67 71, Denis.Duboule{at}unige.ch, Denis.Duboule{at}epfl.ch
  • ↵# Present address: Department of Basic Neurosciences, University of Geneva, Switzerland.

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THE HOXD CLUSTER IS A DYNAMIC AND RESILIENT TAD BOUNDARY CONTROLLING THE SEGREGATION OF ANTAGONISTIC REGULATORY LANDSCAPES
Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J. Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hahn Nguyen Huynh, Hakan Ozadam, Job Dekker, Denis Duboule
bioRxiv 193706; doi: https://doi.org/10.1101/193706
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THE HOXD CLUSTER IS A DYNAMIC AND RESILIENT TAD BOUNDARY CONTROLLING THE SEGREGATION OF ANTAGONISTIC REGULATORY LANDSCAPES
Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Ye Zhan, Pierre J. Fabre, Leonardo Beccari, Imane El-Idrissi, Thi Hahn Nguyen Huynh, Hakan Ozadam, Job Dekker, Denis Duboule
bioRxiv 193706; doi: https://doi.org/10.1101/193706

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