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Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron

View ORCID ProfileElisa Galliano, Eleonora Franzoni, Marine Breton, Annisa N. Chand, Darren J. Byrne, View ORCID ProfileVenkatesh N. Murthy, View ORCID ProfileMatthew S. Grubb
doi: https://doi.org/10.1101/196006
Elisa Galliano
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
2Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, 02138 Cambridge MA, USA
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Eleonora Franzoni
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Marine Breton
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Annisa N. Chand
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Darren J. Byrne
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Venkatesh N. Murthy
2Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, 02138 Cambridge MA, USA
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Matthew S. Grubb
1Centre for Developmental Neurobiology, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK
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Abstract

Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally-generated neurons often match those of their embryonically-produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation: the axon initial segment (AIS). Large AIS-positive axon-bearing DA neurons are exclusively produced during early embryonic stages, leaving small anaxonic AIS-negative cells as the only DA subtype generated via adult neurogenesis. These populations are functionally distinct: large DA cells are more excitable, yet display weaker and more broadly-tuned responses to odorant stimuli. Embryonic and postnatal neurogenesis can therefore generate distinct neuronal subclasses, placing important constraints on the functional roles of adult-born neurons in sensory processing.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted September 29, 2017.
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Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa N. Chand, Darren J. Byrne, Venkatesh N. Murthy, Matthew S. Grubb
bioRxiv 196006; doi: https://doi.org/10.1101/196006
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Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron
Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa N. Chand, Darren J. Byrne, Venkatesh N. Murthy, Matthew S. Grubb
bioRxiv 196006; doi: https://doi.org/10.1101/196006

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