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Glioma Through the Looking GLASS: the Glioma Longitudinal Analysis consortium, molecular evolution of diffuse gliomas

The GLASS consortium, Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde CM Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, D Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter AE Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel GW Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, WK Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat
doi: https://doi.org/10.1101/196139
Department of Laboratory Medicine and Patholobiology University of Toronto, 101 College St, Toronto, ON, Canada M5G 1L7
Kenneth Aldape
Department of Laboratory Medicine and Patholobiology University of Toronto, 101 College St, Toronto, ON, Canada M5G 1L7
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Samirkumar B Amin
The Jackson Laboratory for Genomic Medicine, Ten Discovery Drive, Farmington, CT, 06032 USA
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David M Ashley
Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina 27710 USA
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Jill S Barnholtz-Sloan
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 2103 Cornell Rd, WRB 2-526, Cleveland, Ohio 44106 USA
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Amanda J Bates
National Brain Tumor Society, 55 Chapel Street, Suite 200, Newton, MA 02458 USA
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Rameen Beroukhim
Departments of Medical Oncology and Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
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Christoph Bock
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria
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Daniel J Brat
Department of Pathology, Feinberg School of Medicine, Northwestern University, 300 East Superior Street, Chicago, IL 60611 USA
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Elizabeth B Claus
Yale School of Public Health, New Haven CT 06511 and Department of Neurosurgery, Brigham and Women’s Hospital, Boston, MA 02115 USA
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Joseph F Costello
The University of California San Francisco, San Francisco, CA 94158 USA
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John F de Groot
The University of Texas - MD Anderson Cancer Center; 1515 Holcombe Blvd, Houston, TX 77030 USA
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Gaetano Finocchiaro
Fondazione IRCCS Istituto Neurologico Besta, via Celoria 11, 20133 Milano, Italy
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Pim J French
Department of Neurology, Erasmus MC, ’s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
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Hui K Gan
Olivia Newton-John Cancer Research Institute, Austin Health, Heidelberg 3084, Melbourne, Victoria, Australia
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Brent Griffith
Department of Radiology, Henry Ford Health System, Detroit, MI 48202 USA
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Christel C Herold-Mende
Div. Experimental Neurosurgery, Dpt Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
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Craig Horbinski
Department of Pathology, Feinberg School of Medicine, Northwestern University, 300 East Superior Street, Chicago, IL 60611 USA
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Antonio Iavarone
Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, 10032 New York USA
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Steven N Kalkanis
Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202 USA
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Konstantina Karabatsou
Salford Royal Hospital, Stott Lane, Greater Manchester, M6 8HD, U.K.
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Hoon Kim
The Jackson Laboratory for Genomic Medicine, Ten Discovery Drive, Farmington, CT, 06032 USA
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Mathilde CM Kouwenhoven
Department of Neurology, VU University Medical Center/Brain Tumor Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
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Kerrie L McDonald
Cure Brain Cancer Biomarkers and Trasnlational Research Group, Prince of Wales Clinical School, University of NSW
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Hrvoje Miletic
Department of Pathology, Haukeland University Hospital, Bergen, Norway
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Do-Hyun Nam
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
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Ho Keung Ng
Department of Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
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Simone P Niclou
Luxembourg Institute of Health, NorLux Neuro-Oncology Laboratory; 84, Val Fleuri, 1526 Luxembourg, Luxembourg
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Houtan Noushmehr
Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202 USA
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D Ryan Ormond
Department of Neurosurgery, University of Colorado School of Medicine, 12631 E. 17th Avenue, Mail Stop C307, Aurora, CO 80203 USA
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Laila M Poisson
Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202 USA
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Guido Reifenberger
Department of Neuropathology, Heinrich Heine University Duesseldorf, Medical Faculty, Moorenstr 5, D-40225 Duesseldorf, Germany
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Federico Roncaroli
Division of Neuroscience & Experimental Psychology, Faculty of Biology, Medicine & Health, University of Manchester, UK Oxford Road M23 9PT
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Jason K Sa
Research Instittute for Future Medicine, Samsung Medical Center, Seoul, Korea
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Peter AE Sillevis Smitt
Department of Neurology, Erasmus MC, ‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
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Marion Smits
Department of Radiology and Nuclear Medicine, Erasmus MC, ‘s-Gravendijkwal 230, 301 CE Rotterdam, The Netherlands
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Camila F Souza
Department of Neurosurgery, Henry Ford Health System, Detroit, MI 48202 USA
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Ghazaleh Tabatabai
Interdisciplinary Division of Neuro-Oncology, Departments of Neurology & Neurosurgery, Unviersity Hospital Tübingen
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Erwin G Van Meir
Departments of Neurosurgery & Hematology and Medical Oncology, School of Medicine and Winship Cancer Insitute, Emory University, 1365C Clifton Rd. NE., Atlanta, GA30322, USA
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Roel GW Verhaak
The Jackson Laboratory for Genomic Medicine, Ten Discovery Drive, Farmington, CT, 06032 USA
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Colin Watts
Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, UK
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Pieter Wesseling
Department of Pathology, VU University Medical Center/Brain Tumor Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands, and Princess Máxima Center for Pediatric Oncology + University Medical Center Utrecht, The Netherlands
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Adelheid Woehrer
Institute of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria
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WK Alfred Yung
UT MD Anderson Cancer Center, Houston, TX 77030 USA
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Christine Jungk
Dpt Neurosurgery, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
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Ann-Christin Hau
Luxembourg Institute of Health, NorLux Neuro-Oncology Laboratory; 84, Val Fleuri, 1526 Luxembourg, Luxembourg
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Eric van Dyck
Luxembourg Institute of Health, NorLux Neuro-Oncology Laboratory; 84, Val Fleuri, 1526 Luxembourg, Luxembourg
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Bart A Westerman
Brain Tumor Center Amsterdam, Cancer Center Amsterdam, VU Medical Center, Amsterdam, The Netherlands
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Julia Yin
Cure Brain Cancer Biomarkers and Trasnlational Research Group, Prince of Wales Clinical School, University of NSW, Australie
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Olajide Abiola
The Jackson Laboratory for Genomic Medicine, Ten Discovery Drive, Farmington, CT, 06032, USA
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Mustafa Khasraw
The University of Sydney, NSW 2006 Australia
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Erik P Sulman
UT MD Anderson Cancer Center, Houston, TX 77030
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Andrea M Muscat
Deakin University, Geelong, VIC. 3220 Australia
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Abstract

Adult diffuse glioma are a diverse group of intracranial neoplasms associated with a disproportional large number of productive life years lost, thus imposing a highly emotional and significant financial burden on society. Patient death is the result of an aggressive course of disease following diagnosis. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant molecular evolution during the malignant transformation. We review current knowledge on genomic, epigenomic and transcriptomic abnormalities before and after disease recurrence. We outline an effort to systemically catalogue the longitudinal changes in gliomas, the Glioma Longitudinal Analysis Consortium. The GLASS initiative will provide essential insights into the evolution of glioma towards a lethal phenotype with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 02, 2017.
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Glioma Through the Looking GLASS: the Glioma Longitudinal Analysis consortium, molecular evolution of diffuse gliomas
The GLASS consortium, Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde CM Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, D Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter AE Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel GW Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, WK Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat
bioRxiv 196139; doi: https://doi.org/10.1101/196139
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Glioma Through the Looking GLASS: the Glioma Longitudinal Analysis consortium, molecular evolution of diffuse gliomas
The GLASS consortium, Kenneth Aldape, Samirkumar B Amin, David M Ashley, Jill S Barnholtz-Sloan, Amanda J Bates, Rameen Beroukhim, Christoph Bock, Daniel J Brat, Elizabeth B Claus, Joseph F Costello, John F de Groot, Gaetano Finocchiaro, Pim J French, Hui K Gan, Brent Griffith, Christel C Herold-Mende, Craig Horbinski, Antonio Iavarone, Steven N Kalkanis, Konstantina Karabatsou, Hoon Kim, Mathilde CM Kouwenhoven, Kerrie L McDonald, Hrvoje Miletic, Do-Hyun Nam, Ho Keung Ng, Simone P Niclou, Houtan Noushmehr, D Ryan Ormond, Laila M Poisson, Guido Reifenberger, Federico Roncaroli, Jason K Sa, Peter AE Sillevis Smitt, Marion Smits, Camila F Souza, Ghazaleh Tabatabai, Erwin G Van Meir, Roel GW Verhaak, Colin Watts, Pieter Wesseling, Adelheid Woehrer, WK Alfred Yung, Christine Jungk, Ann-Christin Hau, Eric van Dyck, Bart A Westerman, Julia Yin, Olajide Abiola, Mustafa Khasraw, Erik P Sulman, Andrea M Muscat
bioRxiv 196139; doi: https://doi.org/10.1101/196139

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