New Results
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelos Evangelou, Helen R Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N Hellwege, Ayush Giri, Digna R Velez Edwards, Yan V Sun, Kelly Cho, J.Michael Gaziano, Peter WF Wilson, Philip S Tsao, Csaba P Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, Philippe Amouyel, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola M Del Greco, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A.Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin C Lehne, Terho Lehtimäki, Daniel Levy, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, Yongmei Liu, Ruth JF Loos, Lorna M Lopez, Lingchan Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Christopher Newton-Cheh, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Arno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Nguyen Quang Tri, Olli T Raitakari, Meixia Ren, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Reid, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniella Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Rheinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Schneider, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Anne-Claire Vergnaud, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Dan Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Ollie Melander, Dennis O Mook-Kanamori, Patricia B Munroe, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Morris J Brown, Andres Metspalu, Adriana M Hung, Christopher J O'Donnell, Todd L Edwards, on behalf of the Million Veteran Program, Bruce M. Psaty, Ioanna Tzoulaki, Michael R Barnes, Louise V Wain, Paul Elliott, Mark J Caulfield
doi: https://doi.org/10.1101/198234
Evangelos Evangelou
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Helen R Warren
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
David Mosen-Ansorena
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Borbala Mifsud
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Raha Pazoki
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
He Gao
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
Georgios Ntritsos
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Niki Dimou
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
Claudia P Cabrera
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
Ibrahim Karaman
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Fu Liang Ng
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Marina Evangelou
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
6Department of Mathematics, Imperial College London, UK
Katarzyna Witkowska
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Evan Tzanis
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Jacklyn N Hellwege
7Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN.
Ayush Giri
7Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN.
Digna R Velez Edwards
8Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center; Tennessee Valley Health Systems VA, Nashville, TN.
Yan V Sun
9Department of Epidemiology and Biomedical Informatics, Emory University Rollins School of Public Health, Atlanta gA, USA.
10Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA.
Kelly Cho
11Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA.
12Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, Department of Medicine, Harvard Medical School, Boston, MA.
J.Michael Gaziano
11Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130, USA.
12Division of Aging, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, Department of Medicine, Harvard Medical School, Boston, MA.
Peter WF Wilson
13Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, 30233.
Philip S Tsao
14VA Palo Alto Health Care System; Division of Cardiovascular Medicine, Stanford University School of Medicine.
Csaba P Kovesdy
15Nephrology Section, Memphis VA Medical Center, Memphis TN.
Tonu Esko
16Estonian Genome Center, University of Tartu, Tartu, Estonia.
17Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA.
Reedik Mägi
16Estonian Genome Center, University of Tartu, Tartu, Estonia.
Lili Milani
16Estonian Genome Center, University of Tartu, Tartu, Estonia.
Peter Almgren
18Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Thibaud Boutin
19MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK
Stéphanie Debette
20Department of Neurology, Bordeaux University Hospital, F-33000 Bordeaux, France.
21University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, France.
Jun Ding
22Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD 21224, USA.
Franco Giulianini
23Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
Elizabeth G Holliday
24Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Anne U Jackson
25Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Ruifang Li-Gao
26Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Wei-Yu Lin
27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jian'an Luan
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Massimo Mangino
29Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
30NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London SE1 9RT, UK.
Christopher Oldmeadow
24Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Bram Prins
31Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Yong Qian
22Laboratory of Genetics and Genomics, NIA/NIH, Baltimore, MD 21224, USA.
Muralidharan Sargurupremraj
21University of Bordeaux, Bordeaux Population Health Research Center, INSERM UMR 1219, F-33000 Bordeaux, France.
Nabi Shah
32Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan.
33Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, DD1 9SY, UK.
Praveen Surendran
27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Sébastien Thériault
34Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St W, Hamilton, L8S 4L8, Canada.
35Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval, 2725 Chemin Ste-Foy, Quebec City, G1V 4G5, Canada.
Niek Verweij
17Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA.
36Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
37University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, The Netherlands.
Sara M Willems
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Jing-Hua Zhao
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Philippe Amouyel
38University of Lille, Inserm, Centre Hosp. Univ Lille, Institut Pasteur de Lille, UMR1167 - RID-AGE - Risk factors and molecular determinants of aging-related diseases, Epidemiology and Public Health Department, F-59000 Lille, France.
John Connell
39University of Dundee, Ninewells Hospital & Medical School, Dundee, DD1 9SY, UK.
Renée de Mutsert
26Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
Alex SF Doney
33Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, DD1 9SY, UK.
Martin Farrall
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
41Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Cristina Menni
29Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Andrew D Morris
42Usher Institute of Population Health Sciences and Informatics, University of Edinburgh.
Raymond Noordam
43Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Guillaume Paré
34Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St W, Hamilton, L8S 4L8, Canada.
Neil R Poulter
44International Centre for Circulatory Health, Imperial College London, London, W2 1PG, UK.
Denis C Shields
45School of Medicine, University College Dublin, Ireland.
Alice Stanton
46Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
Simon Thom
44International Centre for Circulatory Health, Imperial College London, London, W2 1PG, UK.
Gonçalo Abecasis
47Center for Statistical Genetics, Dept. of Biostatistics, SPH II, 1420 Washington Heights, Ann Arbor, MI 48109-2029.
Najaf Amin
48Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Dan E Arking
49Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kristin L Ayers
50Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Caterina M Barbieri
51Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
52Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65, Trieste, 34200, Italy.
Chiara Batini
53Department of Health Sciences, University of Leicester, Leicester, UK.
Joshua C Bis
54Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.
Tineka Blake
53Department of Health Sciences, University of Leicester, Leicester, UK.
Murielle Bochud
55Institute of Social and Preventive Medicine, University Hospital of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
Michael Boehnke
25Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Eric Boerwinkle
56Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston and Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.
Dorret I Boomsma
57Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ institute, VU University medical center, Amsterdam, the Netherlands.
Erwin P Bottinger
58The Charles Bronfman Institute for Personalized Medicine, Icachn School of Medicine at Mount Sinai, New York, NY 10029.
Peter S Braund
59Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
60NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.
Marco Brumat
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
Archie Campbell
62Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
63Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, UK.
Harry Campbell
64Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh EH89AG, Scotland, UK
Aravinda Chakravarti
49Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
John C Chambers
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
65Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
66Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK
67Imperial College Healthcare NHS Trust, London W12 0HS, UK.
Ganesh Chauhan
68Bordeaux University, Bordeaux, France.
69INSERM U 1219, Bordeaux Population Health center, Bordeaux, France.
Marina Ciullo
70Institute of Genetics and Biophysics "A. Buzzati-Traverso ", CNR, via P. Castellino 111, 80131 Napoli - Italy.
71IRCCS Neuromed, Pozzilli, Isernia, Italy.
Massimiliano Cocca
52Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65, Trieste, 34200, Italy.
Francis Collins
72Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Heather J Cordell
73Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Gail Davies
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
75Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Martin H de Borst
76Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
Eco J de Geus
57Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ institute, VU University medical center, Amsterdam, the Netherlands.
Ian J Deary
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
75Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Joris Deelen
77Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2300RC, the Netherlands.
Fabiola M Del Greco
78Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Germany.
Cumhur Yusuf Demirkale
79Center for Information Technology, NIH.
Marcus Dörr
80Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany.
81DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
Georg B Ehret
49Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
82Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Roberto Elosua
83Cardiovascular Epidemiology and Genetics, IMIM. Dr Aiguader 88, Barcelona, 08003 Spain.
Stefan Enroth
84Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Husargatan 3, Uppsala, SE-75108, Sweden.
A.Mesut Erzurumluoglu
53Department of Health Sciences, University of Leicester, Leicester, UK.
Teresa Ferreira
85The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK
Mattias Frånberg
86Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
87Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, 171 76, Sweden.
88Department of Numerical Analysis and Computer Science, Stockholm University, Lindstedtsvägen 3, Stockholm, 100 44, Sweden.
Oscar H Franco
89Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Ilaria Gandin
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
Paolo Gasparini
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
90IRCCS-Burlo Garofalo Children Hospital, Via dell’Istria 65, Trieste, Italy.
Vilmantas Giedraitis
91Department of Public Health and Caring Sciences, Geriatrics, Uppsala 752 37, Sweden.
Christian Gieger
92Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
93Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
94German Center for Diabetes Research (DZD), Neuherberg, Germany.
Giorgia Girotto
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
95IRCCS-Burlo Garofalo Children Hospital, Via dell’Istria 65, Trieste, Italy.
Anuj Goel
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
41Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Alan J Gow
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
96Department of Psychology, School of Social Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
Vilmundur Gudnason
97Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
98Icelandic Heart Assoication, Kopavogur, Iceland.
Xiuqing Guo
99The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Ulf Gyllensten
84Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Husargatan 3, Uppsala, SE-75108, Sweden.
Anders Hamsten
86Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
87Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, 171 76, Sweden.
Tamara B Harris
100Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging.
Sarah E Harris
62Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
Catharina A Hartman
101Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.
Aki S Havulinna
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Andrew A Hicks
78Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Germany.
Edith Hofer
103Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
104Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Auenbruggerplatz 2, 8036 Graz, Austria.
Albert Hofman
89Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
105Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jouke-Jan Hottenga
57Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ institute, VU University medical center, Amsterdam, the Netherlands.
Jennifer E Huffman
106MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Shih-Jen Hwang
107The Framingham Heart Study, Framingham MA 01702.
108The Population Science Branch, Division of Intramural Research, National Heart Lung and Blood Institute National Institute of Health, Bethesda, MD 20892.
Erik Ingelsson
109Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 752 37, Sweden.
110Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alan James
111Department of Pulmonary Physiology and Sleep, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands 6009, H57 Western Australia.
112School of Medicine and Pharmacology, University of Western Australia.
Rick Jansen
113Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands.
Marjo-Riitta Jarvelin
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
114Biocenter Oulu, P.O. Box 5000, Aapistie 5A, FI-90014 University of Oulu, Finland.
115Center For Life-course Health Research, P.O.Box 5000, FI-90014 University of Oulu, Finland.
116Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O. Box 20, FI-90220 Oulu, 90029 OYS, Finland.
Roby Joehanes
117Hebrew SeniorLife, Harvard Medical School, 1200 Centre Street Room #609, Boston, MA 02131.
118National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Åsa Johansson
84Department of Immunology, Genetics and Pathology, Uppsala Universitet, Science for Life Laboratory, Husargatan 3, Uppsala, SE-75108, Sweden.
Andrew D Johnson
118National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
119National Heart, Lung and Blood Institute, Population Sciences Branch, Bethesda, MD 20814, USA.
Peter K Joshi
64Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh EH89AG, Scotland, UK
Pekka Jousilahti
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
J Wouter Jukema
120Department of Cardiology, Leiden University Medical Center, Leiden, 2300RC the Netherlands.
Antti Jula
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Mika Kähönen
121Department of Clinical Physiology, Tampere University Hospital, Tampere 33521, Finland.
122Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland.
Sekar Kathiresan
17Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, USA.
36Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
123Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.
Bernard D Keavney
124Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
125Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Kay-Tee Khaw
126Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge CB2 2SR, UK.
Paul Knekt
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Joanne Knight
127Data Science Institute and Lancaster Medical School, Furness College, LA1 4YG, Lancaster.
Ivana Kolcic
128Department of Public Health, Faculty of Medicine, University of Split, Croatia.
Jaspal S Kooner
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
67Imperial College Healthcare NHS Trust, London W12 0HS, UK.
129Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
130National Heart and Lung Institute, Imperial College London, London, UK.
Seppo Koskinen
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Kati Kristiansson
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Zoltan Kutalik
55Institute of Social and Preventive Medicine, University Hospital of Lausanne, Route de la Corniche 10, 1010 Lausanne, Switzerland.
131Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Maris Laan
132Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila Str. 19, 50412 Tartu, Estonia.
Marty Larson
118National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
Lenore J Launer
100Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging.
Benjamin C Lehne
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Terho Lehtimäki
133Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
134Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Daniel Levy
118National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01702, USA.
119National Heart, Lung and Blood Institute, Population Sciences Branch, Bethesda, MD 20814, USA.
David CM Liewald
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
75Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Li Lin
82Cardiology, Department of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
Lars Lind
135Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
Cecilia M Lindgren
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
136Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.
Yongmei Liu
137Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, 27106, USA.
Ruth JF Loos
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
138Mindich Child health Development Institute, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
139The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lorna M Lopez
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
140Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland.
141University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.
Lingchan Lu
58The Charles Bronfman Institute for Personalized Medicine, Icachn School of Medicine at Mount Sinai, New York, NY 10029.
Leo-Pekka Lyytikäinen
133Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland.
134Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Anubha Mahajan
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Chrysovalanto Mamasoula
142Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.
Jaume Marrugat
83Cardiovascular Epidemiology and Genetics, IMIM. Dr Aiguader 88, Barcelona, 08003 Spain.
Jonathan Marten
106MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Yuri Milaneschi
143Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Oldenaller 1, 1081 HJ Amsterdam Amsterdam, The Netherlands.
Anna Morgan
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
Andrew P Morris
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
144Department of Biostatistics, University of Liverpool, Block F, Waterhouse Building, 1-5 Brownlow Street, Liverpool L69 3GL, UK.
Alanna C Morrison
145Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, 1200 Pressler St., Suite 453E, Houston, TX 77030, USA.
Peter J Munson
79Center for Information Technology, NIH.
Mike A Nalls
146Data Tecnica International, Glen Echo, MD, USA.
147Laboratory of Neurogenetics, National Institute on Aging, Bethesda, USA.
Priyanka Nandakumar
49Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Christopher P Nelson
59Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
60NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.
Christopher Newton-Cheh
136Program in Medical and Population Genetics, Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA.
148Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
149Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Teemu Niiranen
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Ilja M Nolte
150Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.
Teresa Nutile
70Institute of Genetics and Biophysics "A. Buzzati-Traverso ", CNR, via P. Castellino 111, 80131 Napoli - Italy.
Albertine J Oldehinkel
151Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, University Medical Center Groningen, PO Box 30001 (CC72), 9700 RB Groningen, The Netherlands.
Ben A Oostra
48Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Paul F O'Reilly
152SGDP Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Elin Org
16Estonian Genome Center, University of Tartu, Tartu, Estonia.
Sandosh Padmanabhan
63Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, UK.
153British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Walter Palmas
154Department of Medicine, Columbia University Medical Center, 622 West 168th Street, PH 9, East, 107, New York, NY 10032, USA.
Arno Palotie
155Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Alison Pattie
75Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Brenda WJH Penninx
143Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, VU University Medical Center/GGZ inGeest, Oldenaller 1, 1081 HJ Amsterdam Amsterdam, The Netherlands.
Markus Perola
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
155Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
156University of Tartu, Tartu, Estonia.
Annette Peters
93Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
Ozren Polasek
128Department of Public Health, Faculty of Medicine, University of Split, Croatia.
Peter P Pramstaller
78Institute for Biomedicine, Eurac Research, Bolzano, Italy - Affiliated Institute of the University of Lübeck, Germany.
157Department of Neurology, General Central Hospital, Bolzano, Italy.
158Department of Neurology, University of Lubeck, Lübeck, Germany.
Nguyen Quang Tri
79Center for Information Technology, NIH.
Olli T Raitakari
159Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland.
160Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
Meixia Ren
161Department of Geriatric Medicine, Fujian Provincial Hospital, Fujian Key Laboratory of Geriatrics, Fujian Medical University, Fuzhou, 350001, China.
162William Harvey Research Institute Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom.
Rainer Rettig
163Institute of Physiology, University Medicine Greifswald, Karlsburg, 17495, Germany.
Kenneth Rice
164Department of Biostatistics University of Washington, Seattle, WA 98101, USA.
Paul M Ridker
23Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
165Harvard Medical School, Boston MA.
Janina S Reid
93Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.
Harriëtte Riese
151Interdisciplinary Center Psychopathology and Emotion regulation (ICPE), University of Groningen, University Medical Center Groningen, PO Box 30001 (CC72), 9700 RB Groningen, The Netherlands.
Samuli Ripatti
155Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
166Public health, Faculty of Medicine, University of Helsinki, Finland
Antonietta Robino
52Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65, Trieste, 34200, Italy.
Lynda M Rose
23Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
Jerome I Rotter
99The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Igor Rudan
167Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh EH89AG, Scotland, UK.
Daniella Ruggiero
70Institute of Genetics and Biophysics "A. Buzzati-Traverso ", CNR, via P. Castellino 111, 80131 Napoli - Italy.
Yasaman Saba
168Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Cinzia F Sala
51Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Veikko Salomaa
102Department of Public Health Solutions, National Institute for Health and Welfare (THL), Helsinki, Finland.
Nilesh J Samani
59Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.
60NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.
Antti-Pekka Sarin
155Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Rheinhold Schmidt
103Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Helena Schmidt
168Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010 Graz, Austria.
Nick Shrine
53Department of Health Sciences, University of Leicester, Leicester, UK.
David Siscovick
169The New York Academy of Medicine. 1216 5th Ave, New York, NY 10029, USA.
Albert V Smith
97Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
98Icelandic Heart Assoication, Kopavogur, Iceland.
Harold Schneider
150Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.
Siim Sõber
132Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila Str. 19, 50412 Tartu, Estonia.
Rossella Sorice
70Institute of Genetics and Biophysics "A. Buzzati-Traverso ", CNR, via P. Castellino 111, 80131 Napoli - Italy.
John M Starr
74Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK.
170Alzheimer Scotland Dementia Research Centre, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
David J Stott
171Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, United Kingdom.
David P Strachan
172Population Health Research Institute, St George's, University of London, London SW17 ORE, UK.
Rona J Strawbridge
86Cardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17176, Sweden.
87Centre for Molecular Medicine, L8:03, Karolinska Universitetsjukhuset, Solna, 171 76, Sweden.
Johan Sundström
135Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 751 85, Sweden.
Morris A Swertz
173Department of Genetics, University of Groningen, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
Kent D Taylor
99The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Alexander Teumer
81DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
174Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Martin D Tobin
53Department of Health Sciences, University of Leicester, Leicester, UK.
Daniela Toniolo
51Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Michela Traglia
51Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Stella Trompet
120Department of Cardiology, Leiden University Medical Center, Leiden, 2300RC the Netherlands.
175Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300RC, the Netherlands.
Jaakko Tuomilehto
176Dasman Diabetes Institute, Dasman, 15462 Kuwait.
177Chronic Disease Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland.
178Department of Public Health, University of Helsinki, 00014 Helsinki, Finland.
179Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.
Christophe Tzourio
68Bordeaux University, Bordeaux, France.
69INSERM U 1219, Bordeaux Population Health center, Bordeaux, France.
180Department of Public Health, Bordeaux University Hospital, Bordeaux, France.
André G Uitterlinden
89Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
181Department of Internal Medicine, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Ahmad Vaez
150Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.
182Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
Peter J van der Most
150Department of Epidemiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands.
Cornelia M van Duijn
48Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Anne-Claire Vergnaud
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Germaine C Verwoert
89Department of Epidemiology, Erasmus MC, Rotterdam, 3000CA, the Netherlands.
Veronique Vitart
106MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Uwe Völker
81DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
183Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.
Peter Vollenweider
184Department of Internal Medicine, University Hospital, CHUV, 1011 Lausanne, Switzerland.
Dragana Vuckovic
61Department of Medical, Surgical and Health Sciences, University of Trieste, Strada di Fiume 447, Trieste, 34100, Italy.
185Experimental Genetics Division, Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
Hugh Watkins
40Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
41Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Sarah H Wild
64Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh EH89AG, Scotland, UK
Gonneke Willemsen
57Department of Biological Psychology, Vrije Universiteit Amsterdam, EMGO+ institute, VU University medical center, Amsterdam, the Netherlands.
James F Wilson
19MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK
64Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh EH89AG, Scotland, UK
Alan F Wright
106MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK.
Jie Yao
99The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, 1124 W. Carson Street, Torrance, CA 90502, USA.
Tatijana Zemunik
186Department of Biology, Faculty of Medicine, University of Split, Croatia.
Weihua Zhang
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
129Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
John R Attia
24Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Adam S Butterworth
27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
187The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, UK.
Dan Chasman
23Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA, USA.
165Harvard Medical School, Boston MA.
David Conen
188Division of Cardiology, University Hospital, Petersgraben 4, 4031 Basel, Switzerland.
189Division of Cardiology, Department of Medicine, McMaster University, 1280 Main St W, Hamilton, L8S 4L8, Canada.
Francesco Cucca
190Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
John Danesh
27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
187The National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, UK.
Caroline Hayward
19MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU Scotland, UK
Joanna MM Howson
27MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Markku Laakso
191Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Edward G Lakatta
192Laboratory of Cardiovascular Science, NIA/NIH, Baltimore, MD 21224,USA.
Claudia Langenberg
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Ollie Melander
18Department Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
Dennis O Mook-Kanamori
26Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
193Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
Patricia B Munroe
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Colin NA Palmer
33Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, DD1 9SY, UK.
Lorenz Risch
194Labormedizinisches Zentrum Dr. Risch, Landstrasse 157, 9494 Schaan, Liechtenstein.
195Private University of the Principality of Liechtenstin, Dorfstrasse 24, 9495 Triesen, Liechtenstein.
196University Insitute of Clinical Chemistry, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
Robert A Scott
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Rodney J Scott
24Hunter Medical Research Institute and Faculty of Health, University of Newcastle, New Lambton Heights, New South Wales, Australia.
Peter Sever
130National Heart and Lung Institute, Imperial College London, London, UK.
Tim D Spector
29Department of Twin Research and Genetic Epidemiology, Kings College London, London SE1 7EH, UK.
Pim van der Harst
197University Medical Center Groningen, University of Groningen, Department of Cardiology, the Netherlands.
Nicholas J Wareham
28MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Eleftheria Zeggini
31Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
Morris J Brown
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
Andres Metspalu
16Estonian Genome Center, University of Tartu, Tartu, Estonia.
Adriana M Hung
198Nashville VA (TVHS) & Vanderbilt University.
Christopher J O'Donnell
199VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School.
Todd L Edwards
7Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN.
Bruce M. Psaty
200Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
201Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
Ioanna Tzoulaki
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
2Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
Michael R Barnes
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
Louise V Wain
53Department of Health Sciences, University of Leicester, Leicester, UK.
Paul Elliott
1Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
5MRC-PHE Centre for Environment and Health, Imperial College London, London W2 1PG, UK.
Mark J Caulfield
3William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
4National Institute for Health Research, Barts Cardiovascular Biomedical Research Center, Queen Mary University of London, London, UK.
Abstract
High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Posted October 11, 2017.
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelos Evangelou, Helen R Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N Hellwege, Ayush Giri, Digna R Velez Edwards, Yan V Sun, Kelly Cho, J.Michael Gaziano, Peter WF Wilson, Philip S Tsao, Csaba P Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, Philippe Amouyel, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola M Del Greco, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A.Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin C Lehne, Terho Lehtimäki, Daniel Levy, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, Yongmei Liu, Ruth JF Loos, Lorna M Lopez, Lingchan Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Christopher Newton-Cheh, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Arno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Nguyen Quang Tri, Olli T Raitakari, Meixia Ren, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Reid, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniella Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Rheinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Schneider, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Anne-Claire Vergnaud, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Dan Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Ollie Melander, Dennis O Mook-Kanamori, Patricia B Munroe, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Morris J Brown, Andres Metspalu, Adriana M Hung, Christopher J O'Donnell, Todd L Edwards, on behalf of the Million Veteran Program, Bruce M. Psaty, Ioanna Tzoulaki, Michael R Barnes, Louise V Wain, Paul Elliott, Mark J Caulfield
bioRxiv 198234; doi: https://doi.org/10.1101/198234
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelos Evangelou, Helen R Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N Hellwege, Ayush Giri, Digna R Velez Edwards, Yan V Sun, Kelly Cho, J.Michael Gaziano, Peter WF Wilson, Philip S Tsao, Csaba P Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, Philippe Amouyel, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola M Del Greco, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A.Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin C Lehne, Terho Lehtimäki, Daniel Levy, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, Yongmei Liu, Ruth JF Loos, Lorna M Lopez, Lingchan Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Christopher Newton-Cheh, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Arno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Nguyen Quang Tri, Olli T Raitakari, Meixia Ren, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Reid, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniella Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Rheinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Schneider, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Anne-Claire Vergnaud, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Dan Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Ollie Melander, Dennis O Mook-Kanamori, Patricia B Munroe, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Morris J Brown, Andres Metspalu, Adriana M Hung, Christopher J O'Donnell, Todd L Edwards, on behalf of the Million Veteran Program, Bruce M. Psaty, Ioanna Tzoulaki, Michael R Barnes, Louise V Wain, Paul Elliott, Mark J Caulfield
bioRxiv 198234; doi: https://doi.org/10.1101/198234
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