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Correlation structure of grid cells is preserved during sleep

View ORCID ProfileRichard J. Gardner, Li Lu, Tanja Wernle, May-Britt Moser, Edvard I. Moser
doi: https://doi.org/10.1101/198499
Richard J. Gardner
Kavli Institute for Systems Neuroscience and Centre for Neural Computation;
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  • For correspondence: richard.grdnr@gmail.com
Li Lu
Department of Neuroscience, Baylor College of Medicine, Houston, USA;
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Tanja Wernle
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
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May-Britt Moser
Kavli Institute for Systems Neuroscience and Centre for Neural Computation;
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Edvard I. Moser
Kavli Institute for Systems Neuroscience and Centre for Neural Computation;
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Abstract

The network of grid cells in the medial entorhinal cortex forms a fixed reference frame for mapping physical space. The mechanistic origin of the grid representation is unknown, but continuous attractor network (CAN) models explain multiple fundamental features of grid-cell activity. An untested prediction of CAN grid models is that the grid-cell network should exhibit an activity correlation structure that transcends behavioural or brain states. By recording from MEC cell ensembles during navigation and sleep, we found that spatial phase offsets of grid cells predict arousal-state-independent spike rate correlations. Similarly, state-invariant correlations between conjunctive grid-head-direction and pure head-direction cells were predicted by their head-direction tuning offsets. Spike rates of grid cells were only weakly correlated across modules, and module scale relationships disintegrated during slow-save sleep, suggesting that modules function as independent attractor networks. Collectively, our observations suggest that network states in MEC are expressed universally across brain and behaviour states.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 05, 2017.
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Correlation structure of grid cells is preserved during sleep
Richard J. Gardner, Li Lu, Tanja Wernle, May-Britt Moser, Edvard I. Moser
bioRxiv 198499; doi: https://doi.org/10.1101/198499
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Correlation structure of grid cells is preserved during sleep
Richard J. Gardner, Li Lu, Tanja Wernle, May-Britt Moser, Edvard I. Moser
bioRxiv 198499; doi: https://doi.org/10.1101/198499

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