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Exploiting modal demultiplexing properties of tapered optical fibers for tailored optogenetic stimulation

Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
doi: https://doi.org/10.1101/199273
Marco Pisanello
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
2Dipartimento di Ingegneria dell’Innovazione, Università del Salento, Lecce, Italy.
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Filippo Pisano
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
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Leonardo Sileo
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
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Emanuela Maglie
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
2Dipartimento di Ingegneria dell’Innovazione, Università del Salento, Lecce, Italy.
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Elisa Bellistri
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
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Barbara Spagnolo
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
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Gil Mandelbaum
3Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, 02115 MA, U.S.A.
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Bernardo L. Sabatini
3Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, 02115 MA, U.S.A.
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Massimo De Vittorio
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
2Dipartimento di Ingegneria dell’Innovazione, Università del Salento, Lecce, Italy.
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Ferruccio Pisanello
1Istituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010 Arnesano (LE), Italy.
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Abstract

Optogenetic control of neural activity in deep brain regions requires precise and flexible light delivery with non-invasive devices. To this end, Tapered Optical Fibers (TFs) represent a minimally-invasive tool that can deliver light over either large brain volumes or spatially confined subregions. This work links the emission properties of TFs with the modal content injected into the fiber, finding that the maximum transversal propagation constant (kt) and the total number of guided modes sustained by the waveguide are key parameters for engineering the mode demultiplexing properties of TFs. Intrinsic features of the optical fiber (numerical aperture and core/cladding diameter) define the optically active segment of the taper (up to ∼3mm), along which a linear relation between the propagating set of kt values and the emission position exists. These site-selective light-delivery properties are preserved at multiple wavelengths, further extending the range of applications expected for tapered fibers for optical control of neural activity.

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Posted October 06, 2017.
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Exploiting modal demultiplexing properties of tapered optical fibers for tailored optogenetic stimulation
Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
bioRxiv 199273; doi: https://doi.org/10.1101/199273
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Exploiting modal demultiplexing properties of tapered optical fibers for tailored optogenetic stimulation
Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
bioRxiv 199273; doi: https://doi.org/10.1101/199273

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