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Nitrate modulates stem cell dynamics by regulating WUSCHEL expression through cytokinins

Benoit Landrein, Pau Formosa-Jordan, Alice Malivert, Christoph Schuster, Charles W. Melnyk, Weibing Yang, Colin Turnbull, Elliot M. Meyerowitz, James C.W. Locke, View ORCID ProfileHenrik Jönsson
doi: https://doi.org/10.1101/200303
Benoit Landrein
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Pau Formosa-Jordan
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Alice Malivert
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Christoph Schuster
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Charles W. Melnyk
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Weibing Yang
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Colin Turnbull
2Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
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Elliot M. Meyerowitz
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
3Howard Hughes Medical Institute and Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA
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James C.W. Locke
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
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Henrik Jönsson
1Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge CB2 1LR, UK
4Computational Biology and Biological Physics Group, Department of Astronomy and Theoretical Physics, Lund University, S-221 00 Lund, Sweden
5Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0DZ, UK
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  • ORCID record for Henrik Jönsson
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Abstract

The shoot apical meristem (SAM) is responsible for the generation of all of the aerial parts of plants1. Given its critical role, dynamical changes in SAM activity should play a central role in the adaptation of plant architecture to the environment2. Using quantitative microscopy, grafting experiments and genetic perturbations, we connect the plant environment to the SAM, by describing the molecular mechanism by which cytokinins signal the level of nutrient availability to the SAM. We show that a systemic signal of cytokinin precursors3 mediates the adaptation of SAM size and organogenesis rate to the availability of mineral nutrients by modulating the expression of WUSCHEL, a key regulator of stem cell homeostasis4. In time-lapse experiments, we further show that this mechanism allows meristems to adapt to rapid changes in nitrate concentration, and thereby modulate their rate of organ production to the availability of mineral nutrients within a few days. Our work sheds new light on the role of the stem cell regulatory network, by showing that it does not only maintain meristem homeostasis but also allows plants to adapt to rapid changes in the environment.

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Posted October 09, 2017.
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Nitrate modulates stem cell dynamics by regulating WUSCHEL expression through cytokinins
Benoit Landrein, Pau Formosa-Jordan, Alice Malivert, Christoph Schuster, Charles W. Melnyk, Weibing Yang, Colin Turnbull, Elliot M. Meyerowitz, James C.W. Locke, Henrik Jönsson
bioRxiv 200303; doi: https://doi.org/10.1101/200303
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Nitrate modulates stem cell dynamics by regulating WUSCHEL expression through cytokinins
Benoit Landrein, Pau Formosa-Jordan, Alice Malivert, Christoph Schuster, Charles W. Melnyk, Weibing Yang, Colin Turnbull, Elliot M. Meyerowitz, James C.W. Locke, Henrik Jönsson
bioRxiv 200303; doi: https://doi.org/10.1101/200303

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