Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery

Sudarshan Chari, Christian Marier, Cody Porter, Emmalee Northrop, Alexandra Belinky, Ian Dworkin
doi: https://doi.org/10.1101/200725
Sudarshan Chari
1Program in Ecology, Evolutionary Biology and Behavior
2BEACON Center for the Study of Evolution in Action
3Department of Integrative Biology Michigan State University
4Lewis-Sigler Institute for Integrative Genomics, Princeton University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian Marier
3Department of Integrative Biology Michigan State University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cody Porter
3Department of Integrative Biology Michigan State University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emmalee Northrop
3Department of Integrative Biology Michigan State University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandra Belinky
3Department of Integrative Biology Michigan State University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Dworkin
1Program in Ecology, Evolutionary Biology and Behavior
2BEACON Center for the Study of Evolution in Action
3Department of Integrative Biology Michigan State University
5Department of Biology, McMaster University
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dworkin@mcmaster.ca
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Populations are constantly exposed to deleterious alleles, most of which are purged via natural selection. However, deleterious fitness effects of alleles can also be suppressed by compensatory adaptation. Compensatory mutations can act directly to reduce deleterious effects of an allele. Alternatively, compensation may also occur by altering other aspects of an organisms’ phenotype or performance, without suppressing the phenotypic effects of the deleterious allele. Moreover, the origin of allelic variation contributing to compensatory adaptation remains poorly understood. Compensatory evolution driven by mutations that arise during the selective process are well studied. However less is known about the role standing (cryptic) genetic variation plays in compensatory adaptation. To address these questions, we examined evolutionary trajectories of natural populations of Drosophila melanogaster fixed for mutations that disrupt wing morphology, resulting in deleterious effects on several components of fitness. Lineages subjected only to natural selection, evolved modifications to courtship behavior and several life history traits without compensation in wing morphology. Yet, we observed rapid phenotypic compensation of wing morphology under artificial selection, consistent with segregating variation for compensatory alleles. We show that alleles contributing to compensation of wing morphology have deleterious effects on other fitness components. These results demonstrate the potential for multiple independent avenues for rapid compensatory adaptation from standing genetic variation, which ultimately may reveal novel adaptive trajectories.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted October 10, 2017.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery
Sudarshan Chari, Christian Marier, Cody Porter, Emmalee Northrop, Alexandra Belinky, Ian Dworkin
bioRxiv 200725; doi: https://doi.org/10.1101/200725
Digg logo Reddit logo Twitter logo Facebook logo Google logo LinkedIn logo Mendeley logo
Citation Tools
Compensatory evolution via cryptic genetic variation: Distinct trajectories to phenotypic and fitness recovery
Sudarshan Chari, Christian Marier, Cody Porter, Emmalee Northrop, Alexandra Belinky, Ian Dworkin
bioRxiv 200725; doi: https://doi.org/10.1101/200725

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Evolutionary Biology
Subject Areas
All Articles
  • Animal Behavior and Cognition (3514)
  • Biochemistry (7365)
  • Bioengineering (5342)
  • Bioinformatics (20318)
  • Biophysics (10041)
  • Cancer Biology (7773)
  • Cell Biology (11348)
  • Clinical Trials (138)
  • Developmental Biology (6450)
  • Ecology (9979)
  • Epidemiology (2065)
  • Evolutionary Biology (13354)
  • Genetics (9370)
  • Genomics (12607)
  • Immunology (7724)
  • Microbiology (19087)
  • Molecular Biology (7459)
  • Neuroscience (41134)
  • Paleontology (300)
  • Pathology (1235)
  • Pharmacology and Toxicology (2142)
  • Physiology (3177)
  • Plant Biology (6878)
  • Scientific Communication and Education (1276)
  • Synthetic Biology (1900)
  • Systems Biology (5328)
  • Zoology (1091)