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Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit

View ORCID ProfileSalvador Dura-Bernal, View ORCID ProfileSamuel A Neymotin, Benjamin A Suter, Gordon M G Shepherd, View ORCID ProfileWilliam W Lytton
doi: https://doi.org/10.1101/201707
Salvador Dura-Bernal
1Dept. Physiology & Pharmacology, SUNY Downstate, USA
2Nathan Kline Institute for Psychiatric Research, USA
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  • For correspondence: salvadordura@gmail.com
Samuel A Neymotin
1Dept. Physiology & Pharmacology, SUNY Downstate, USA
2Nathan Kline Institute for Psychiatric Research, USA
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Benjamin A Suter
3Department of Physiology, Northwestern University, USA
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Gordon M G Shepherd
3Department of Physiology, Northwestern University, USA
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William W Lytton
1Dept. Physiology & Pharmacology, SUNY Downstate, USA
4Dept. Neurology, Kings County Hospital Center, USA
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Abstract

We developed a biophysically detailed multiscale model of mouse primary motor cortex (M1) with over 10,000 neurons and 35 million synapses. We focused on intratelencephalic (IT) and pyramidal-tract (PT) neurons of layer 5 (L5), which were modeled at high multicompartment resolution. Wiring densities were based on prior detailed measures from mouse slice, and depended on cell class and cortical depth at sublaminar resolution. Prominent phase-amplitude-coupled delta and gamma activity emerged from the network. Spectral Granger causality analysis revealed the dynamics of information flow through populations at different frequencies. Stimulation of motor vs sensory long-range inputs to M1 demonstrated distinct intra- and inter-laminar dynamics and PT output. Manipulating PT Ih altered PT activity, supporting the hypothesis that Ih neuromodulation is involved in translating motor planning into execution. Our model sheds light on the multiscale dynamics of cell-type-specific M1 circuits and how connectivity relates to dynamics.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 16, 2019.
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Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit
Salvador Dura-Bernal, Samuel A Neymotin, Benjamin A Suter, Gordon M G Shepherd, William W Lytton
bioRxiv 201707; doi: https://doi.org/10.1101/201707
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Multiscale dynamics and information flow in a data-driven model of the primary motor cortex microcircuit
Salvador Dura-Bernal, Samuel A Neymotin, Benjamin A Suter, Gordon M G Shepherd, William W Lytton
bioRxiv 201707; doi: https://doi.org/10.1101/201707

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