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Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia
View ORCID ProfileAndre Altmann, David M Cash, Martina Bocchetta, Carolin Heller, Regina Reynolds, Katrina Moore, Rhian S Convery, David L Thomas, John van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Markus Otto, Mina Ryten, Jonathan D Rohrer, on behalf of the Genetic FTD Initiative, GENFI.
doi: https://doi.org/10.1101/2019.12.11.872143
Andre Altmann
1Centre of Medical Image Computing, Department of Medical Physics, University College London, London, UK
PhDDavid M Cash
1Centre of Medical Image Computing, Department of Medical Physics, University College London, London, UK
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
PhDMartina Bocchetta
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
PhDCarolin Heller
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
BScRegina Reynolds
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
Katrina Moore
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
BScRhian S Convery
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
MScDavid L Thomas
3Neuroimaging Analysis Centre, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London, UK
PhDJohn van Swieten
4Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands
PhDFermin Moreno
5Cognitive Disorders Unit, Department of Neurology, Donostia University Hospital, San Sebastian, Gipuzkoa, Spain
MD PhDRaquel Sanchez-Valle
6Alzheimer’s disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, University of Barcelona, Barcelona, Spain
PhDBarbara Borroni
7Centre for Neurodegenerative Disorders, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
MDRobert Laforce Jr
8Clinique Interdisciplinaire de Mémoire du CHU de Québec, Département des Sciences Neurologiques Université Laval Québec, Québec, Canada
MD PhDMario Masellis
9Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada
MD PhDMaria Carmela Tartaglia
10Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
MDCaroline Graff
11Department of Geriatric Medicine, Karolinska University Hospital-Huddinge, Stockholm, Sweden
MD PhDDaniela Galimberti
12Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Centro Dino Ferrari, Milan, Italy
13Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy
PhDJames B. Rowe
14Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom
FRCP PhDElizabeth Finger
15Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario Canada
MDMatthis Synofzik
16Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany
17German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
MDRik Vandenberghe
18Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
MD PhDAlexandre de Mendonça
19Laboratory of Neurosciences, Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
MD PhDFabrizio Tagliavini
20Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Neurologica Carlo Besta, Milano, Italy
MDIsabel Santana
21Faculty of Medicine, University of Coimbra, Coimbra, Portugal
MD PhDSimon Ducharme
22Department of Psychiatry, McGill University Health Centre, McGill University, Montreal, Québec, Canada
MDChris Butler
23Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
FRCP PhDAlex Gerhard
24Faculty of Medical and Human Sciences, Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
FRCP PhDJohannes Levin
25Department of Neurology, Ludwig-Maximilians-University, Munich, Germany
26German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
27Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
MDAdrian Danek
25Department of Neurology, Ludwig-Maximilians-University, Munich, Germany
MDGiovanni Frisoni
28Instituto di Recovero e Cura a Carattere Scientifico Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
PhDRoberta Ghidoni
29Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
PhDSandro Sorbi
30Department of Neuroscience, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy
PhDMarkus Otto
31Department of Neurology, University of Ulm, Ulm
MDMina Ryten
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
MD PhDJonathan D Rohrer
2Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK
FRCP PhD
Posted December 12, 2019.
Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia
Andre Altmann, David M Cash, Martina Bocchetta, Carolin Heller, Regina Reynolds, Katrina Moore, Rhian S Convery, David L Thomas, John van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Markus Otto, Mina Ryten, Jonathan D Rohrer, on behalf of the Genetic FTD Initiative, GENFI.
bioRxiv 2019.12.11.872143; doi: https://doi.org/10.1101/2019.12.11.872143
Analysis of brain atrophy and local gene expression implicates astrocytes in Frontotemporal dementia
Andre Altmann, David M Cash, Martina Bocchetta, Carolin Heller, Regina Reynolds, Katrina Moore, Rhian S Convery, David L Thomas, John van Swieten, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce Jr, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Markus Otto, Mina Ryten, Jonathan D Rohrer, on behalf of the Genetic FTD Initiative, GENFI.
bioRxiv 2019.12.11.872143; doi: https://doi.org/10.1101/2019.12.11.872143
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