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The transcriptional legacy of developmental stochasticity

View ORCID ProfileSara Ballouz, Maria T. Pena, Frank M. Knight, Linda B. Adams, Jesse A. Gillis
doi: https://doi.org/10.1101/2019.12.11.873265
Sara Ballouz
1The Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA
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  • ORCID record for Sara Ballouz
Maria T. Pena
2US Department of Health and Human Services, Health Resources and services Administration, Healthcare System Bureau, National Hansen’s Disease Program. Baton Rouge, LA, 70803, USA
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Frank M. Knight
3University of the Ozarks, Clarksville, AR 72830, USA
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Linda B. Adams
2US Department of Health and Human Services, Health Resources and services Administration, Healthcare System Bureau, National Hansen’s Disease Program. Baton Rouge, LA, 70803, USA
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Jesse A. Gillis
1The Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA
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  • For correspondence: jgillis@cshl.edu
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Abstract

Genetic variation, epigenetic regulation and major environmental stimuli are key contributors to phenotypic variation, but the influence of minor perturbations or “noise” has been difficult to assess in mammals. In this work, we uncover one major axis of random variation with a large and permanent influence: developmental stochasticity. By assaying the transcriptome of wild monozygotic quadruplets of the nine-banded armadillo, we find that persistent changes occur early in development, and these give rise to clear transcriptional signatures which uniquely characterize individuals relative to siblings. Comparing these results to human twins, we find the transcriptional signatures which define individuals exhibit conserved co-expression, suggesting a substantial fraction of phenotypic and disease discordance within mammals arises from developmental stochasticity.

One sentence summary Longitudinal gene expression in identical armadillo quadruplets reveals a major role for developmental stochasticity.

Footnotes

  • https://github.com/sarbal/ayotochtli

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted December 12, 2019.
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The transcriptional legacy of developmental stochasticity
Sara Ballouz, Maria T. Pena, Frank M. Knight, Linda B. Adams, Jesse A. Gillis
bioRxiv 2019.12.11.873265; doi: https://doi.org/10.1101/2019.12.11.873265
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The transcriptional legacy of developmental stochasticity
Sara Ballouz, Maria T. Pena, Frank M. Knight, Linda B. Adams, Jesse A. Gillis
bioRxiv 2019.12.11.873265; doi: https://doi.org/10.1101/2019.12.11.873265

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