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Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
doi: https://doi.org/10.1101/2019.12.11.873398
Chongyuan Luo
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
3Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA
Hanqing Liu
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
4Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA
Fangming Xie
5Department of Physics, University of California, San Diego, La Jolla, CA 92037, USA
6Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA
Ethan J. Armand
6Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA
Kimberly Siletti
7Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Trygve E. Bakken
8Allen Institute for Brain Science, Seattle, WA, USA
Rongxin Fang
9Ludwig Institute for Cancer Research, La Jolla, CA, USA
10Center for Epigenomics, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, Moores Cancer Center, University of California San Diego, School of Medicine, La Jolla, CA, USA
Wayne I. Doyle
6Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA
Rebecca D. Hodge
8Allen Institute for Brain Science, Seattle, WA, USA
Lijuan Hu
7Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Bang-An Wang
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Zhuzhu Zhang
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Sebastian Preissl
10Center for Epigenomics, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, Moores Cancer Center, University of California San Diego, School of Medicine, La Jolla, CA, USA
Dong-Sung Lee
11Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA
Jingtian Zhou
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Sheng-Yong Niu
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Rosa Castanon
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Anna Bartlett
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Angeline Rivkin
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Xinxin Wang
9Ludwig Institute for Cancer Research, La Jolla, CA, USA
10Center for Epigenomics, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, Moores Cancer Center, University of California San Diego, School of Medicine, La Jolla, CA, USA
Jacinta Lucero
12Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Joseph R. Nery
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
David A. Davis
13Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA
Deborah C. Mash
13Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, 33136, USA
Jesse R. Dixon
11Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA
Sten Linnarsson
7Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Ed Lein
8Allen Institute for Brain Science, Seattle, WA, USA
M. Margarita Behrens
12Computational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Bing Ren
9Ludwig Institute for Cancer Research, La Jolla, CA, USA
10Center for Epigenomics, Department of Cellular and Molecular Medicine, Institute of Genomic Medicine, Moores Cancer Center, University of California San Diego, School of Medicine, La Jolla, CA, USA
Eran A. Mukamel
6Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA
Joseph R. Ecker
1Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
2Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Article usage
Posted December 12, 2019.
Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
bioRxiv 2019.12.11.873398; doi: https://doi.org/10.1101/2019.12.11.873398
Single nucleus multi-omics links human cortical cell regulatory genome diversity to disease risk variants
Chongyuan Luo, Hanqing Liu, Fangming Xie, Ethan J. Armand, Kimberly Siletti, Trygve E. Bakken, Rongxin Fang, Wayne I. Doyle, Rebecca D. Hodge, Lijuan Hu, Bang-An Wang, Zhuzhu Zhang, Sebastian Preissl, Dong-Sung Lee, Jingtian Zhou, Sheng-Yong Niu, Rosa Castanon, Anna Bartlett, Angeline Rivkin, Xinxin Wang, Jacinta Lucero, Joseph R. Nery, David A. Davis, Deborah C. Mash, Jesse R. Dixon, Sten Linnarsson, Ed Lein, M. Margarita Behrens, Bing Ren, Eran A. Mukamel, Joseph R. Ecker
bioRxiv 2019.12.11.873398; doi: https://doi.org/10.1101/2019.12.11.873398
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