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Molecular layer interneurons in the cerebellum encode for valence in associative learning

Ming Ma, Gregory L. Futia, Baris N. Ozbay, Emily A. Gibson, Diego Restrepo
doi: https://doi.org/10.1101/2019.12.14.876201
Ming Ma
Neuroscience Graduate ProgramDepartment of Cell and Developmental Biology
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Gregory L. Futia
Department of Bioengineering University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Baris N. Ozbay
Intelligent Imaging Innovations, Denver, CO, 80216.
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Emily A. Gibson
Department of Bioengineering University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
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Diego Restrepo
Neuroscience Graduate ProgramDepartment of Cell and Developmental Biology
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  • For correspondence: diego.restrepo@cuanschutz.edu
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Abstract

We used two-photon microscopy to study the role of ensembles of cerebellar molecular layer interneurons (MLIs) in a go-no go task where mice obtain a sugar water reward if they lick a spout in the presence of the rewarded odorant and avoid punishment when they restrain from licking for the unrewarded odorant. When the animal was naïve to the valence of the stimulus (is the odorant rewarded?) responses of the MLIs did not differ between odorants. However, as the animal became proficient, the rewarded odorant elicited a large increase in Ca2+ in MLIs, and the identity of the odorant could be decoded from the differential response. Importantly, MLIs switched odorant responses when the valence of the stimuli was reversed. Finally, licks diverged more slowly and mice did not become proficient when MLIs were inhibited by chemogenetic intervention. Our findings support a role for MLIs in learning valence in the cerebellum.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 15, 2019.
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Molecular layer interneurons in the cerebellum encode for valence in associative learning
Ming Ma, Gregory L. Futia, Baris N. Ozbay, Emily A. Gibson, Diego Restrepo
bioRxiv 2019.12.14.876201; doi: https://doi.org/10.1101/2019.12.14.876201
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Molecular layer interneurons in the cerebellum encode for valence in associative learning
Ming Ma, Gregory L. Futia, Baris N. Ozbay, Emily A. Gibson, Diego Restrepo
bioRxiv 2019.12.14.876201; doi: https://doi.org/10.1101/2019.12.14.876201

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