Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Attractor dynamics gate cortical information flow during decision-making

View ORCID ProfileArseny Finkelstein, View ORCID ProfileLorenzo Fontolan, Michael N. Economo, Nuo Li, View ORCID ProfileSandro Romani, Karel Svoboda
doi: https://doi.org/10.1101/2019.12.14.876425
Arseny Finkelstein
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Arseny Finkelstein
Lorenzo Fontolan
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lorenzo Fontolan
Michael N. Economo
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nuo Li
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
2Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sandro Romani
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Sandro Romani
  • For correspondence: svobodak@janelia.hhmi.org
Karel Svoboda
1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: svobodak@janelia.hhmi.org
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Decisions about future actions are held in memory until enacted, making them vulnerable to distractors. The neural mechanisms controlling decision robustness to distractors remain unknown. We trained mice to report optogenetic stimulation of somatosensory cortex, with a delay separating sensation and action. Distracting stimuli influenced behavior less when delivered later during delay – demonstrating temporal gating of sensory information flow. Gating occurred even though distractor-evoked activity percolated through the cortex without attenuation. Instead, choice-related dynamics in frontal cortex became progressively robust to distractors as time passed. Reverse-engineering of neural networks trained to reproduce frontal-cortex activity revealed that chosen actions were stabilized via attractor dynamics, which gated out distracting stimuli. Our results reveal a dynamic gating mechanism that operates by controlling the degree of commitment to a chosen course of action.

One Sentence Summary Mechanisms controlling state-dependent communication between brain regions allow for robust action-selection.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted December 15, 2019.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Attractor dynamics gate cortical information flow during decision-making
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Attractor dynamics gate cortical information flow during decision-making
Arseny Finkelstein, Lorenzo Fontolan, Michael N. Economo, Nuo Li, Sandro Romani, Karel Svoboda
bioRxiv 2019.12.14.876425; doi: https://doi.org/10.1101/2019.12.14.876425
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Attractor dynamics gate cortical information flow during decision-making
Arseny Finkelstein, Lorenzo Fontolan, Michael N. Economo, Nuo Li, Sandro Romani, Karel Svoboda
bioRxiv 2019.12.14.876425; doi: https://doi.org/10.1101/2019.12.14.876425

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4665)
  • Biochemistry (10324)
  • Bioengineering (7649)
  • Bioinformatics (26269)
  • Biophysics (13487)
  • Cancer Biology (10656)
  • Cell Biology (15385)
  • Clinical Trials (138)
  • Developmental Biology (8474)
  • Ecology (12789)
  • Epidemiology (2067)
  • Evolutionary Biology (16810)
  • Genetics (11375)
  • Genomics (15441)
  • Immunology (10589)
  • Microbiology (25111)
  • Molecular Biology (10182)
  • Neuroscience (54283)
  • Paleontology (399)
  • Pathology (1663)
  • Pharmacology and Toxicology (2885)
  • Physiology (4329)
  • Plant Biology (9218)
  • Scientific Communication and Education (1584)
  • Synthetic Biology (2548)
  • Systems Biology (6766)
  • Zoology (1459)