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Resistance to dieldrin evolution in African malaria vectors is driven by interspecific and interkaryotypic introgression

View ORCID ProfileXavier Grau-Bové, View ORCID ProfileSean Tomlinson, View ORCID ProfileAndrias O. O’Reilly, View ORCID ProfileNicholas J. Harding, View ORCID ProfileAlistair Miles, View ORCID ProfileDominic Kwiatkowski, View ORCID ProfileMartin J. Donnelly, View ORCID ProfileDavid Weetman, The Anopheles gambiae 1000 Genomes Consortium
doi: https://doi.org/10.1101/2019.12.17.879775
Xavier Grau-Bové
1Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
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  • For correspondence: xavier.graubove@gmail.com
Sean Tomlinson
1Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
2Centre for Health Informatics, Computing and Statistics, Lancaster University, Lancaster
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Andrias O. O’Reilly
3School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool, UK
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Nicholas J. Harding
4Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, United Kingdom
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Alistair Miles
4Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, United Kingdom
5Wellcome Sanger Institute, Hinxton, United Kingdom
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Dominic Kwiatkowski
4Big Data Institute, University of Oxford, Li Ka Shing Centre for Health Information and Discovery, United Kingdom
5Wellcome Sanger Institute, Hinxton, United Kingdom
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Martin J. Donnelly
1Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
5Wellcome Sanger Institute, Hinxton, United Kingdom
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David Weetman
1Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
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Abstract

The evolution of insecticide resistance mechanisms in natural populations of Anopheles malaria vectors is a major public health concern across Africa. Using genome sequence data, we study the evolution of resistance mutations in the resistance to dieldrin gene (Rdl), a GABA receptor targeted by several insecticides, but most notably by the long-discontinued cyclodiene, dieldrin. The two Rdl resistance mutations (296G and 296S) spread across West and Central African Anopheles via two independent hard selective sweeps that included likely compensatory nearby mutations, and were followed by a rare combination of introgression across species (from A. gambiae and A. arabiensis to A. coluzzii) and across non-concordant karyotypes of the 2La chromosomal inversion. Rdl resistance evolved in the 1950s as the first known adaptation to a large-scale insecticide-based intervention, but the evolutionary lessons from this system highlight contemporary and future dangers for management strategies designed to combat development of resistance in malaria vectors

Footnotes

  • ↵6 https://www.malariagen.net/projects/ag1000g#people

  • https://github.com/xgrau/rdl-Agam-evolution

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted December 17, 2019.
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Resistance to dieldrin evolution in African malaria vectors is driven by interspecific and interkaryotypic introgression
Xavier Grau-Bové, Sean Tomlinson, Andrias O. O’Reilly, Nicholas J. Harding, Alistair Miles, Dominic Kwiatkowski, Martin J. Donnelly, David Weetman, The Anopheles gambiae 1000 Genomes Consortium
bioRxiv 2019.12.17.879775; doi: https://doi.org/10.1101/2019.12.17.879775
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Resistance to dieldrin evolution in African malaria vectors is driven by interspecific and interkaryotypic introgression
Xavier Grau-Bové, Sean Tomlinson, Andrias O. O’Reilly, Nicholas J. Harding, Alistair Miles, Dominic Kwiatkowski, Martin J. Donnelly, David Weetman, The Anopheles gambiae 1000 Genomes Consortium
bioRxiv 2019.12.17.879775; doi: https://doi.org/10.1101/2019.12.17.879775

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